I bought once at 0.13. Went up to .22, then back down to 14 cents, sold at 0.16 because I got scared. Bought back in at 0.22. Sold enough shares to recoup my initial investment at .56 ($1500). Its all free money here. Gonna ride it until it stops going up. Right now this stock has cost me nothing. Up $4500 of virtual money from zero dollars cost to me right now. I really wish I didn't freak out at 16 cents. I initially had 2000 at 0.13. would have about 8000 now. Oh well.
Sorry, typo. Where I say "INO lacks a littlle in the antigen component" it should say "INO lacks a littlle in the adjuvant component"
I've said it before on both boards (ONCS and INO). The technology is the same but the science is not. ONCS does not a cancer vaccine. It has a cancer adjuvant. IL-12 is a protein your own body makes during immune responses. ONCS plasmid is the IL-12 plasmid, so it makes your cells that get transfected with the plasmid make IL-12. This is not a specific treatment for melanoma or merkel cell carcinoma. It is a non-specific immune adjuvant. Check out Ziopharm for another way to get IL-12 into cells of interest. They use an adenoviral vector instead of electroporation to get the IL-12 plasmid into cells. It is controlled with an intrexon based on- off switch to control the level of IL-12. Same end result for ZIOP and ONCS. More IL-12.
Inovio uses actual DNA encoding antigens or protein components (of viruses, bacteria, or mutated self/cancer proteins) with electroporation to produce the DNA vaccine. Although the DNA vaccine itself activates the innate immune system by activating intracellular DNA sensors, INO lacks a littlle in the antigen component (hence, why they recently started adding a IL-33 plasmid.
INO success does not equal ONCS success. Similarly, ONCS success does not equal INO success. I am not saying either will fail. But so many people think success by INO validates ONCS, but that is not true. Success in ZIOP validates ONCS and vice versa.
Also PD-1 trials do not validate INO or ONCS. The PD-1 inhibitor takes off the natural brake on T cells. IL-12 activates T cells to become T helper 1 cells and cytotoxic T cells, as well as activates NK cells. But the more IL-12 you have, and the more immune activation you have, the more PD-1 gets induced to put more brakes on the system. That's why I really like ONCS combining their IL-12 with a PD-1 inhibitor.
If either ONCS or INO fail their next stage in the clinical trial, it is not over by any stretch of the imagination (ONCS can add antigen, INO can add adjuvant). If they succeed tho, its just the beginning
Please please please bring it. If this drops to 5 cents, I will pick up another truck load of shares. If you don't do that as well with all your bashing, what is your point of being here? Will you stop bashing then?when it dropped to 7.5 cents, I didn't have any money available . Now I do.
Wow. That was a quick dislike. Can I get another? Sorry for putting your undies in a bunch shorty...
Type in "VGX Animal Health DNA Vaccine for Dogs Could Reduce Tumor Growth and Increase Survival"
Its the dog version of the TERT vaccine. Shrinks tumors in dogs
What about ones that cause heart failure? Like imatinib and sunitinib? They seem to be doing just fine and staying on the market. A little reversible blood clotting is nothing two of these couldn't fix. But please don't call me in the morning.
Remember, this rumor was started by the Street. The same guys who stomped the rumor the first time... Hmmm... Does Cramer have an agenda? I wonder.
Its going to 10-12 just with the rumor. But you're right. Double from here depending on partner news.
See my post in regards to farmer John's thread.
Thewhole field is validated by ISIS. This is catching up to the potential valuation.
It still may fail. But the tech is valid.
Have you seen all of the RNA interference companies? This is the year of the RNAi companies, not just MRNA. RXII and MRNA are the last of the bunch (besides RNA which just had their IPO. The RNA antisense technology was validated by ISIS. RNAi is the next step up with regards to technological breakthrough in the field.
ISIS then ALNY then ARWR then TKMR, now RXII and MRNA.
Pay attention to the science. Pay attention to the field.
RNAi is hot now, as is batteries (today).
Just a question, so that I know how stupid you are. Are you being paid to just type garbage (in which case you are forgiven)? Or are you truly shorting the company (in which case, well...)?
Thanks for worrying. We'll be alright. Now go to sleep. It may be the last night-night you get in your bed for a while, once your creditors come after you.
Trust me Jim , I'm a doctor. Actually two of them. MD-PhD. Know nothing about investing. Only know the science and the medicine. I had another post on this board explaining how Iclusig was best in class a whole back even despite the non lethal clotting. Explaining how Gleevec and sunatinib cause heart failure in 1% of patients. Non lethal blood clots, even if arterial, is much easier to treat than stage III-IV NY criteria heart failure... No matter what the good doctor Adam Fartstain says. Oh wait. He's a poly-sci major. I went through 13 years of additional training than AF (after undergrad). But what the fudge do I know? Cheers to all. That's why I put 90% of my personal investment in ARIA back in Dec. b/c I'm a doctor. Not an investor
I don't understand you pumpers. How is a 30% response rate better than the competitors enough for you to say this product is "best in class." It makes no sense. It causes blood clots that have not killed anyone. Can't you see the forest from the trees? I am going to short this down to zero.
If you guys can't tell, this is sarcasm. I am long 10K shares. Holding through earnings, and the rest of the year, possibly longer depending on what projections they make with what's in the pipeline. Lots of brain power in Cambridge, Mass. A few good institutions of higher learning are there. ARIA is in the thick of things. Good things to come. If not tomorrow, very, very soon.
There are many published studies and unpublished vaccines that most investors have no idea about. Dr. Kim was waiting for $3 to start the PR storm. It took this long to get to $3. That will become the new base.
Dr. Kim has, what, 90% of his net worth in INO? He will make sure he gets the most out of it now.