I think I misunderstood your first post, I thought you were saying that about INOs vaccines, but after looking back at your post, I think you were saying that about vaccines in general. Sorry if I did misunderstand. As I said in my follow up posts- we are in agreement about most of the points.
3) I never said vaccines are 100% safe, in fact I said they can make children with immunodeficiencies very sick, and can cause allergic reactions. INOs (and other) DNA vaccines do neither. In theory, if you make the person's body make a viral or cancer protein (that is a component of the vaccine) they have been exposed to and they had an allergic reaction to it, you can get allergic to that component. But that is very unlikely, especially since the adjuvant they use is usually IL-12, which drives cell mediated immunity, not the 2 types of f immunity that you get allergies to (T helper 2 or immediate hypersensitivity-IgE mediated) immunity.
Last comment about point 1: Vaccine components do not cross the blood brain barrier unless someone has a problem with the blood brain barrier to begin with. Alum used as an adjuvant actually helps make the vaccine more viscous, and when you inject it intramuscularly allows very slow release of the protein (over the course of days. Those components go to the lymph nodes first, then the lymph duct than the heart, then into the blood. From there the major places it goes to are the spleen, lung, and liver (organs with no barrier unlike the brain). By the time anything gets to the brain, it is so diluted, maybe one particle per million would cross if at all.
Wow. you are way off.
1). I agree there is controversy with autism, and for now, lets leave it at that. There are large, population based studies in high impact medical journals that show there is NO link between autism and vaccinations. There are large population based studies in low impact medical journals that show there is a link between autism and vaccinations. Now, what that tells me is the studies showing a link could not rigorously prove methodologically and statistically that there is an actual link. I personally believe the articles published in the more "scientific" journals like JAMA, J Pediatrics, etc, then the ones published in Journal of Toxicology and Environmental Health A. (I've never heard of that journal).
OK, so lets see what has been associated with the development of autism spectrum diseases in vaccinated children. 1) Measles component of MMR. 2) Mercury 3) Thimerasol. 4) Alum. INO is not working on a measles vaccine, there is no mercery in ANY vaccines anymore, INO has no need for thimerasol as a preservative, and no need for alum as an adjuvant in INO vaccines. So, that means to me, that INO vaccines eliminates the risk for autism development in children, yes?
2) INO vaccines are pure. Pure DNA and water. They are synthetically made by a machine that just combines 4 bases (A, T, G, and C) and makes them into a circular piece of DNA. Like I said the generation of other vaccines results in bacterial components or mammalian cellular components going into the vaccine because the proteins or viruses need to be purified from cell cultures, resulting in impurities. I mentioned this, so we are in agreement.
I have all 3... CPRX is the one I am putting money in today. An investor person told me it broke some sort of resistance, last one til 4.20.
Also have IMMU. Had good news earlier this week and some investor said it may enter in some upward tunnel or wormhole. Its been going up 3-4% per day since.
Is that different than directly injecting a foreign protein into your body? Yes. But your body is producing it, so it is more natural than injected a protein that was harvested from cultures of E. coli, a bacteria isolated from poop.
So, the problems that people have with vaccines:
1) Can a vaccine make you sick: yes, very. If a baby has an immunodeficiency, and it is not diagnosed yet because the baby is getting mother's milk (which has antibodies and protects the baby for up to a month after the mother stops breast feeding), and receives a live, attenuated vaccine such as MMR, they are at risk for developing the infection that they are trying to prevent.
Can a DNA vaccine make you sick? No. Your body produces only the antigenic portions of the viral (or whatever your vaccinating against) proteins, and never produces a complete virus. Safety first!!!
2) Can you be allergic to a vaccine? Absolutely. If you are allergic to eggs, you can be allergic to albumin (egg protein) that is used to stabilize proteins in a vaccine. You can also be allergic to other components in a vaccine, such as thimerasol, but most vaccines don't contain thimerasol anymore anyway (but other preservatives are still there.
Can you be allergic to a DNA vaccine? In theory yes; All it is is DNA, water, and an electric jolt; but there are some people that can be allergic to water when it touches the skin, so in theory, anything is possible. DNA is so stable, there is no need for preservatives or stabilizers. That's why we can get DNA from cavemen that are preserved in amber. Elimanates many allergens.
3) Can you get autism from a vaccine? Absolutely not. The most preposterous thing I have ever heard. The actual data from that guy in Britain has been refuted many times, but don't tell Jenny McCarthy that :-)
Can you get autism from a DNA vaccine? Absolutely not. In theory its only the measles component of the MMR vaccine that was reported to be possibly be associated with autism. INO does not have a measles vaccine.
As to question of stigma of DNA therapy. I cannot answer that question. In theory its a form of temporary genetic engineering. Your cells make a foreign protein for two weeks, then they stop.
Mark, I saw an interview with Dr. Kim where he hinted that he may want to go this alone, no partnership... He seemed very confident that the results would be positive, and I saw the immunological responses to HPV, which were very impressive, so I can see where he gets the confidence.
With this 10 million that INO received from Roche, and the 15 million they received from the public offering this year that went to funding the VGX program, that's 25 million they have right there. My question is that enough funding to continue solo?
MMMMmux...I love your ulterior motives and your predictions that happen 100% of the time (in your dreams). Didn't you say we were going back to $0.70 and he is "shorting this turd"? Now we are going to go to $3.00 by next June and we need PR to avoid going below 2.00. I wish we can all be like you. I love magical thinking.
Can vaccines even get orphan status? Why yes, yes they can.
Article in 2005, British Medical Journal: (not about w/ INO, more about it later)
"New TB vaccine granted orphan drug status
EDITOR—We report how orphan drug status is also relevant for global diseases most prevalent in developing countries
One third of the world's population is chronically infected with tuberculosis (TB), and 500 children die every day.1 The current BCG vaccine protects children against disseminated disease but confers variable protection against lung disease in adults. A recombinant modified vaccinia virus Ankara expressing the antigen 85A gene from Mycobacterium tuberculosis (MVA85A) is being developed to enhance the immunogenicity"
How you say can a drug or vaccine that is used for a disease that affects 1/3 of the world's population? Easy, there is a loophole in "orphan status" when a disease is so devastating, has no cure or limited treatments, you can orphan/fast track the trial and approval
So what happened to that TB vaccine?
Article in Lancet,March 2013
"Safety and efficacy of MVA85A, a new tuberculosis vaccine, in infants previously vaccinated with BCG: a randomised, placebo-controlled phase 2b trial"
Skipping to the conclusions: "Interpretation" MVA85A was well tolerated and induced modest cell-mediated immune responses. Reasons for the ABSENCE of MVA85A efficacy against tuberculosis or M tuberculosis infection in infants need exploration."
Note the phrase "Absence of efficacy"
Why do I bring this up with INO? Well lets talk fast track/orphan status. Which vaccine can potentially qualify for orphan status?
HIV, check, no vaccine preventative or treatment. A vaccine to do either would be a major coup/triumph of science
Hep C, check, no vaccine
Lassa fever, chickunganya, Ebola, Marburg, check. Who wants hemorrhagic fevers anyway.
Tb vaccine, check, well a different vaccine already got it.
Universal cancer (TERT), check, prevent cancer, that's orphan like Oliver Twist
Some pharmas use academic centers to run their clinical trials. Some use private practice doctors. CTIX for instance is using Dana Farber cancer institute and Baylor MD Anderson.
Its easier because they have protocols in place already and its plug and go. Its more difficult to recruit patients to study sites not an academic center.
Sorry about the electroporation comment above... I thought INO is using Cellectra for all of their studies now and not the med pulser any more. Med pulser is what ONCS is using now for their melanoma study.
Chrontech isn't an academic institute and they were using an obsolete device for electroporation.
Yes, basically everything they are using is cheap. A plasmid for the scale they need when made in bulk would cost less than 10 cents per one individual vaccine. A small electrical applicator to attach to the Cellectra device with two nodes for electricity to pass through with a tiny needle should also cost what, a few bucks, each?
This is what I am waiting for as well.
No why do your own when an academic institute is doing a Phase II trial for you?
They are listed on the clinical trials dot gov page with INO for the trial