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Trius Therapeutics, Inc. (TSRX) Message Board

pylesm 81 posts  |  Last Activity: Jul 25, 2014 2:43 AM Member since: Jan 6, 1999
  • Reply to

    Options Expire Tomorrow - 9 is the Key

    by theinnerage Jul 24, 2014 11:02 PM
    pylesm pylesm Jul 25, 2014 2:43 AM Flag

    I think you're seeing open interest after today. I checked a few days ago and could have sworn open interest at 9 was in the four figures. I think a lot of calls were covered and closed out today.

  • pylesm pylesm Jul 25, 2014 2:37 AM Flag

    Actually his returns aren't that much lower than most hedge funds are expecting to return this year (2014). Hedge funds are having a horrible year (see CNBC article 7/21).

  • pylesm pylesm Jul 24, 2014 10:46 PM Flag

    Looks like a lot of the $9 calls got closed out today, so at least from the options perspective, there's little reason to take it lower.

  • Reply to

    After hours it is up to $6.19/share

    by mariocuturic Jul 24, 2014 5:53 PM
    pylesm pylesm Jul 24, 2014 10:17 PM Flag

    200 day moving average is about 6.60 or so. If the pattern continues, the price should retrace at or slightly above it, before the next leg down. I'm not a chart reader, but IMHO the bear price trend reverses on a closing price over 7.20.

  • Reply to

    Something is definitely fishy...

    by vaqeel12690 Jul 24, 2014 8:11 PM
    pylesm pylesm Jul 24, 2014 9:36 PM Flag

    The hedge fund could have been a major writer of naked calls that expire tomorrow at strike 9. It is in their interest to ensure those calls expire worthless. There was a bunch of them at strikes 10 and 9. I figured the price would be kept below 10, but I didn't think 9 was in play. That took a prediction of a $1 target price to get it below 9... just one possibility.

  • Reply to

    BBC story about lack of antibiotics

    by leytonorientfan Jul 2, 2014 9:12 AM
    pylesm pylesm Jul 24, 2014 12:45 AM Flag

    The video is available to view on "top documentary films" web site. I only wish they were farther along in clinical trials. It's on my watch list of "safe" biotech investments.

  • Reply to

    Any one know

    by butchmass Jul 23, 2014 10:32 AM
    pylesm pylesm Jul 23, 2014 10:35 AM Flag

    There are lots of calls sold at strike 10 expiring 7/25. Just give it some time to work through the options overhang.

  • pylesm pylesm Jul 23, 2014 10:32 AM Flag

    MJ is for nausea in general .. not just for cancer. If you get a bad flu, try using an inhaler with some MJ and you'll be amazed how that nauseous feeling is immediately relieved.

  • Reply to

    what are the catalysts in the next 6 months

    by lenndj62 Jul 21, 2014 9:30 PM
    pylesm pylesm Jul 22, 2014 9:14 PM Flag

    That target was posted before the acquisition that brought in the melanoma treatment... so IMHO it's for AMR-001 only.

  • Reply to

    Time Table From FDA Site....

    by pylesm Jul 18, 2014 9:47 PM
    pylesm pylesm Jul 19, 2014 5:01 PM Flag

    Here goes for the fifth time since yesterday.. YAHOO keeps deleting my posts. Yes, I noticed I should have used resumed instead of restarted. The 90 day clock starts after the submission is accepted. FDA web sites states it normally takes 15 days for the initial review before the 90 day clock starts. I think the FDA overshot the 15 day review period... but we don't know because Venaxis never told us when the submission was accepted. Right now there's a lot of uncertainty here, that Venaxis needs to clarify if they want investors to return to the stock.

  • Reply to

    Time Table From FDA Site....

    by pylesm Jul 18, 2014 9:47 PM
    pylesm pylesm Jul 19, 2014 4:56 PM Flag

    IMHO when the FDA accepted the original submission, they conceded the results were good enough for approval (I was wondering about the specificity). Perhaps Venaxis may need to provide some AI on the device (APPYReader), but given it's already approved in Europe (2013), that gives me hope the device requires no re-design. I can't see any reason to require another human trial unless APPYReader is deficient in some way.

    MNKD totally messed up their second FDA submission due to the inhaler. The inhaler was designed to be cleaned and re-used indefinitely. However, the trials showed there were problems with that process, so MNKD tried to switch to their smaller, disposable inhaler in the middle of the trial. FDA issued a CRL for that ... and cost MNKD another $100M +.

    DSCO resubmitted around five times due to drug manufacturing facilities... and they still had problems after that during the rollout.

  • Note the ball is mostly in APPY's court. They have 180 days to respond and if all is in order, the 90 day review clock restarts. Hopefully they will work with the FDA to get it right the first time around. There are consulting firms that specialize in managing the entire process. MNKD used one to help them through the process. I wonder if APPY did?

    From the FDA web site:
    A. Response to an AI Request
    A response to an FDA AI request is the submission of additional information, addressing all of the deficiencies identified in that AI request, that allows FDA to continue or complete the substantive review and reach a decision on the 510(k) submission.

    The submitter should provide a complete response to an AI request from FDA. The response should address all of the deficiencies identified by FDA in its AI request.

    The submitter’s submission of a response to an AI request is an action that, upon receipt by FDA, resumes the FDA review clock, i.e., the 90-day review clock resumes upon receipt of the additional information.

    Note: If FDA determines that the submitter has not addressed one or more of the deficiencies identified in the AI request, the review cycle will be terminated until FDA receives a response addressing the remaining deficiencies. In such a case, FDA intends to inform the submitter by telephone, fax, or e-mail that the response is incomplete and, therefore, the review clock has not resumed. In such a case, the 510(k) will be placed back on hold as of the date of the AI request, and the submitter will have 180 days from the date of the AI request in which to submit a complete response, or the 510(k) will be considered to be withdrawn.

    If the submitter submits unsolicited additional information that constitutes a new indication for use or a new technology, because this information would essentially require FDA to restart the substantive review, the submitter will be required to submit a new 510(k) and the associated fee.

  • Reply to

    Ph 2a news?

    by spittinimage6 Jul 10, 2014 1:41 PM
    pylesm pylesm Jul 17, 2014 4:28 AM Flag

    Check out the Zacks article. They state:

    We estimate top line data will be available in the third quarter.

  • Reply to

    Seeking The Truth About The RS

    by pylesm Jul 15, 2014 10:39 PM
    pylesm pylesm Jul 16, 2014 5:40 PM Flag

    Thanks for the info. The first biotech that I was in that did a RS was CMSI. It is still around under a different name: BLFS. I sold C before they did their RS.

    This sounds like ZLCS where mgmt had a RS ready if needed, but never did it. I wonder if DVAX mgmt wants to have rights to enact a RS if the price slips below $1?

    I'm currently in MNKD, MACK, NBS, APPY (took a wild ride today). Have made a good $$$ in MNKD and MACK. NBS is a long shot and is only a phase II trial, but BAX has a similar phase III going in parallel and NBS is working with BAX on that trial.

    APPY got its first set of questions back from the FDA on their submission and looks like shorts pounced on it thinking it was an outright rejection.

    I'm also in LVL, DWX, SDIV, KBWD, CEFL, DVHL, LMLP and cash.

  • Reply to

    Seeking The Truth About The RS

    by pylesm Jul 15, 2014 10:39 PM
    pylesm pylesm Jul 16, 2014 5:38 PM Flag

    Most of the ones I've seen do a reverse were pretty much forced to in order to stay listed. A couple stated the reason was to exceed the magic $5 threshold to attract additional institutional investors. If timed with a positive catalyst an RS seems to have no detrimental price effect and could possibly attract some new investors.

    I was in Citibank when they announced their RS, so I promptly sold it. Glad I did because the RS resulted in a pretty significant price drop

  • Reply to

    FDA doesn't reject drugs

    by dcxavier Jul 16, 2014 12:21 PM
    pylesm pylesm Jul 16, 2014 4:32 PM Flag

    IMHO this is an expected part of the process after the initial 90 day review period. If this is a CRL and the company didn't report it as such in their press release, they just invited in the legal vultures to pick them clean

    I have to fault the company for not providing more clarity... but this is the same mgmt. that put out a press release on the last offering that completely omitted the warrants (bringing down the offering from $2.40 to $2.14).

  • Reply to

    Seeking The Truth About The RS

    by pylesm Jul 15, 2014 10:39 PM
    pylesm pylesm Jul 16, 2014 4:17 PM Flag

    Thanks. I only buy individual stocks in the biotech sector. Small biotech stocks are easy to hedge around a single binary event. Also they have high IV so the calls are usually pricey. I just sold calls for $9K on MACK for a single month out (aug). That probably won't happen again next month, but you can generate some decent short-term income from high IV biotechs.

  • I'm targeting DVAX as my next biotech target to buy. I like to stake a position before the crowd assembles, usually 9 - 18 months out, then sell out-of-the money covered calls on my shares to make up for the extra time.

    What concerns me is that the posts about a possible RS. Any opinions on whether this is just message board BS or is it a real possibility. It would seem to make no sense to me for DVAX to do a RS at this time. I've been in other biotech stocks where a RS was tried to attract institutional investors and it's always failed to do so.

  • pylesm pylesm Jul 15, 2014 4:25 PM Flag

    We're not in a bubble overall. We're just about where we would have been if the 2008/2009 takedown had not occurred.

    Yellen seemed to be trying to prevent another 1990's style tech bubble forming around some sectors of the stock market. I give her credit in attempting to learn from Greenspan's mistakes. IMHO though, her words will be forgotten in another six weeks, the biotech sector will regain its losses, and the traders will have profited nicely from the Yellen induced volatility.

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