Yes but jennerex shareholders are capped at 150. Do a risk weighted pv calc on that. To do it right you would need to know the upfront payment. After all anyone can offer to give you
contingent money in the future if it doesn't cost them anything out of pocket. It's still bust. I've seen a lot of these deals. my guess is cash was between 10 and 30 most likely at the lower end. Also, I forgot whether royalties were high single digits or low double. Either way it tels you the science isn't good. Promising compounds get deals in the high teens to low 20s
The deal calls for up to a max or 150mm on milestones and royalties (don't hold your breath). Present value of the deal? prolly 2 mm or so. Don't know where you got the 160k .There was an upfront payment but I couldn't find out what it was. Another nail in the coffin for the magic bean theory of viral cancer treatments. It's really silly when you step back for a second isn't it? You seem to be one of the few with at least some sense. Why are you still in ONCY? If nothing else your time horizon has been moved out another half decade or so. ZERO PHASE III's. How old are you anyway?
Is there nothing to stoopid and ludicrous for you dopes to believe??? Single blind p3's a "well trod path!" Funny sheeazit. Brain it our for me dopes. Yer a physician and your pt spikes a fever, you peek and find out he isn't in the reo arm. What to do???? Hmmmm let's see, if he's not in the treatment arm why am I going to continue with the trial on carbotax, an outdated treatment? I took an oath to do the best I can for my patients and now I know he isn't getting the magic beans!!!!. Three years and hundred million dollars from now you will be hearing the same sheeeazit about confounds as physician drop out when they find their patients aren't on REO. They will be 15 years in, and science has already moved on, which brings me to the point. The fact that reo doesn't work is only half of your problem. The other half (as I pointed out a year ago) is that carBotax is no longer the preferred (in fact it was never the preferred) protocol in second line scchn. IT'S CISPLATIN AND ERBITUX. Before you jaxashes post nonsense, i get it,--- but you ain't really here for the mkt (if any) for pts who can't tolerate either cisplatain or erbitux are you??? So spare me. So now you will have a combo trial with an outdated regimen--- sweet!!!! Where do I sign up?
There is a lot of exciting science out there. Take your beating like men --step back. Reassess the situation based on CURRENT facts and move on. (Except kenny, armed and Grim Boy ----- Double down dudes!!!!!!!
1)"Reo works really well on distal Mets (where it is cleared) and especially on lung and liver cancer".-----UHHH NOT the story for the first 10 years. "the where reo clears" theory is about 6 months old and ginned up in response to a failed p3. Also not to put too fine a point on it but, everything is cleared in the lungs lymph and liver so why isn't chemo more effective as its "cleared"-- You can get back to me on that if you wish.
2) "REO does not work terribly well as mono therapy"--- Boy you got that right. You could have stopped right after "REO does not work" It doesn't work by itself. C'mon you can say it-- Repeat after me "REO DOESN"T WORK BY ITSELF" As the story stands now --REO doesn't do ANYTHING other than make cancer cells all crispy so that the real cancer agents work better. You can review all the pretty slides that show the MOA if you wish. But oh-oh now the crispy theory has been replaced by the "where reo clears" theory. I guess maybe when the virus finally gets where it needs to go (after it has been subjected to the immune response against it, ) the crispy theory kicks back in and all these dead viral particles do their magic making the mets cancer all crispy so that the REAL cancer agents can work better. Doesn't this all sound ad hoc and a bit silly? I guess not to folks like Kenny, the Grim Boy and Armed Lunatic.
"Question: which group lives longest?" Answer: Apparently the ones that leave the botched trial and ineffective REO treatment and seek real second line SOC treatment whic. But of course you won't hear that from the company. People living longer on other therapies are euphemistically and conveniently called "confounds"
Well I'll leave you guys in peace. The action is pretty much done. No need to thank me. As the market makes record highs enjoy your 70% losses and pray for the poor trial participants and future suckers
Do you think the mets group is gonna move the OS needle? Remember just cuz they haven't reported them doesn't mean they are alive, or survived 150 days--- 25 or so are in the control and should be long dead (according to you) which moves the OS needle LEFT and the remaining (if all goes well) move it back basically to where it is now give or take a patient or two. It's pretty simple isn't it, if the pts split 50-50, on the 150 number, the median OS doesn't move a day- Even at 80-20 in your favor (which would be remarkable since half are in the control arm) you only move the needle right by 15 pts. Whats that come to? 2 - 3 weeks maybe.
Your first problem is believing what brad says. Appaerntly you don't read much either. In dec ther were (apparently ) 105 pts with mets (before you make a clown of yourself they were "evaluable mets") which means that there are (were )about 62 with loco only-- Add in a few mets who were not evaluable - fantasize a bit. You ONCY longs are good at that.
So the numbers (apparently) are 62 loco only 56 mets and loco (derived from the 118 announced in the PR) and 49 mets only. Here is my point (yet again) By what combination of science, logic, statiistics, ethics, or any other discipline do you get to take the 49 pts WITH METS & loco and put them with the loco only folks? Why would you take people WITH METS and take them OUT of the METS group? Feature me that brain boy.
As it stands now, the original MOA went out the window, when they split the tria, to be replaced by the "magic catcher's mitt" theory of fibrous loco tumors (later revised to the "where reo is cleared" theory) So apparently reo works in mets (whether you adhere to the "catchers mitt" or the " where REO is cleared" theory) you with me so far? but ONLY - ONLY in mets where the pt doesn't have also locoregional disease. That is the ineluctable, inescapable, incontrovertible logical conclusion to be drawn from mgmt's story of REO. #$%$? I mean really - #$%$? If it works in mets then put EVERYONE WITH METS in the SAME group and tell us what that data looks like. (I think we know).
OH and BTW they have 49 pts who are mets only (apparently)-- In essence, not even SCCHN pts. Now I know that if you have a primary cancer and you get another cancer it's is considered metastatic from the primary-- but 50 pts with NO cancer in their heads or necks in an H&N trial?Rreally? I wonder how many came from Grozny?
And now they are talking about running a single blind registration trial? Here's a tip grim boy-- don't trade any more cows for those magic
No opinion on why they put pts with both mets and loco in the loco (118 pts) group instead of the mets group??
You do understand that some of the loco pts also had mets, so why come they don't put the pts with both loco and mets in the mets group instead of the 118 pt group? What is scientific basis for partitioning "mets only" from "mets with loco"? Why not anyone with mets in a "mets group" and only those with loco in a "loco only" group? Do you have any reason why they parsed the patients that way?- is there any empirical evidence or logical basis, based on the supposed MOA that would indicate that you should parse the pts the way ONCY did---or is just a statistical anomaly that allows ONCY to make the allocation and give ONCY another bite at this throughly rotten apple.
Of course if ONCY mgmt wasn't constantly trying to play hide the salami you'd already know the answer.
I no you're on th edje my donkey. Losing 250K of you inherited money must sting. But don't do anything foolish. Maybe some Valerian root and Camomile tea will calm you down. You POS
I love you my teabggin donkey-- look into the cyber face of the teabag. He comes on command. Anggry plaible and dummm as a bag of hammers.
eek? (sic) too friggin funny. You're priceless donkey
have run away after a quick show of bravado after the beatdown in the p3. Thank god. Maybe armed lunatic offed himself. Have there been any mass shootings lately? Poor carravecchio is long gone. Kenny is off buying another drool bucket and practicing his speech to his wife. Not many cheerleaders left. The smart ones (ha-ha) took their beatings like men and moved on.
Noseguy, nome and grim boy are about the only ones who remain.
OMG haven't you humiliated yourself enough with the prescient prediction of a 295 day median for locoregional? A monkey throwing at a dart board with 295 numbers on it had a 98% chance of doing better than you!!!! Unblind at 10% you say? Hmmmm they released locoregional on 118 leaving about 49 in mets. You can at least do that calc can't you? So if they release at 10% that would imply that there were another 12 or so in loc when they unblinded leaving only 37 in mets but co already told you ther were about 50 (forgot exact number) in mets so yer math don't figger. Seems like they waited until the last pt died. No reason to think they will do it differently with mets. They will wait til fda deadline or last pt. Typical for this sleazy mgmt team. NO reason to wait at this point.
PS how many angels can dance on the head of a pin??
Wow. How many clues do you people need?
OH and the mets effect? It had been noted before but was "buried deep in the literature and PNCU didn't know about it" according to BT. And if you have mets only they should be healthier than folks with mets and locoregional, pts the company conveniently decided to group with loco-- Can you give me your "scientific" reason for putting pts with mets and loco in the loco group instead of the mets group??? Let me know what the ouija board says.
Another donkey added to the stable. Donkeys like you see truth as trash. You're probably a teabag too. Here's a little tidbit to chew on donkey. The old soc in second line was cisplatin so why they decided to do a carbotax study is puzzling to me, but now the new soc is --guess what?
cetuximab in second-line (THAT WOULD BE SECOND LINE NOME) therapy.
Three phase II trials examined the role of cetuximab in platinum-refractory or platinum-resistant disease. All patients received cetuximab intravenously (i.v.) at an initial loading dose of 400 mg/m2 followed by weekly 250 mg/m2 [59–61]. In two of these studies cetuximab was added to the platinum compound that was reintroduced [59, 60], in one study cetuximab was given alone . There was a remarkable similarity in outcome in these three studies. Responses were seen in 10%–13% of patients, DC was observed in 46%–55% of patients and median OS was 5.2–6.1 months. This similarity, irrespective of whether cetuximab was administered as a single agent or added to a platinum-based regimen, indicates that the observed responses were attributable to cetuximab alone rather than to the reversal of platinum resistance by cetuximab.
Interestingly, the median survival of 5–6 months achieved with cetuximab in platinum-refractory disease was reaching a level very close to that with first-line therapy in randomized trials and represented an INCREASE IN SURVIVAL OF 2.5 months compared with platinum-refractory historical controls . Based on these results and particularly considering the fact that ∼50% of the patients showed DC, cetuximab monotherapy seems to be a good option for patients with R/M-SCCHN who have progressed on platinum-based chemotherapy. It is also approved for that indication in the USA.
You gotta wonder how many pts that ONCY refused to report on went over Cetuximab and what the results were.
Donkey? Is that you I hear braying? You forgot to mention that you were thankful for losing about 70% of your investment. And thankful that the trial was a failure and thankful the Brad refuses to tell you how 30 patients performed? And thankful wifey (or boyfriend) doesn't know. Ask yourself this donkey. If pts performed better on an alternative therapy as ONCY has indicated, wouldn't that be bad news for the reo carbotax nonsense and perhaps indicate that there are better therapies for second line (there are and I've done told you what the new SOC in second line is) out there. As a donkey, I don't spose you thought about that at all. Not only is reo a failure, carbotax is not even soc second line any longer. Doing another p3 with a proven failure in combo with an outdated protocol is shameful. But what else would Brad and Matt do that would make them 700k a year or os?? The mets indication, no matter what it turns out to be in the 40 pts or so of this botched trial, will surely fail in a larger trial.
Good morning donkey. As the British say. Keep a stiff upper lip. Have you told wifey how truly schtoopid you have been with her hard earned money? . How much have you lost. Insane donkey has lost about half a million bucks (if you believe him). U both shudda listened to your intellectual superiors. Take an English comp class at your local cc with the 80 bucks you have left
There is nothing to defend. They fudged the data. Get used to it. The only good thing to come out of the announcement was the lawsuit. Culling out 30 patients and refusing to release that data is a new low - even for ONCY.
Some of the cultists prolly still don't think the trial was botched. And some may even believe REO works despite the empirical evidence that establishes that in a randomized trial it failed. I wonder how many mets pts they will cull, or conversely if the data looks good, how many will they keep in that should be culled if they apply the unique methodology used in the loco regional half trial.
I really like the idea of an open label p3-- The FDA ought to have a pretty good yukkk on that.
I think that arm will fail too for all the reasons I set forth long ago, but you have one more chance to save what's left of your money before this goes to 50 cents and ultimately to zero.
You are free to believe as you wish. But I have told you that any insider who posts on a message board is a complete fool. And since the trial was blind, brokerage firms would have zero inside info--Only the company and the researchers would have any worthwhile info.
I just love you my little donkey. I think I'll get you a cyber apple. Funny stuff. Does wife know you have lost half the rent money in the last 3 months!!!!!!!
Tell us about your DD. Try and be precise. You might start with the most recent news (well part of the news since ONCY refuses to even tell you what the results are) of the failed p3.
I wonder where my insane donkey is. He isn't so smug these days.
All in all a very sad time for some friends and family of mine, but I'm cheered by that fact that guys like you have lost money.
Get back in your stable with my other donkeys. You be powerful schtooopid. I love your comments on defamation law. Did you go to law school or just pick that up n your spare time?
I love it when teabags who can't even spell opine on the law. Funny sheeazit my little donkey-- not crackin wise so much these days I see. But I doubt you really have 100k shares or thereabouts. In any event, schtttopid usually gets what it deserves.