Last night on BBC they announced that a man in Poland whose spine had been severed in a stabbing incident was walking again after being treated with cells taken from his nasal passages. I had to think back on what might have been the result if Geron had been allowed to give the full dosage required to effect recovery, not merely enough to subject the patients to years of observation out of fears of teratomas and/or human embryos growing at the inoculation site. I understand pretty well what the FDA is up against in terms of oversight and criticism. Because of that, they are pretty much bound by regulation, policy, procedure and protocol. But all of those were developed to serve a much different approach to medicine than Geron was pursuing in the case of stem cells. It has never made sense to me (and never will) to have made those patients who received Geron’s treatment into long-term observational subjects, rather than giving them a chance of real recovery. Nor could the congress have been engaged as a source for change. They’re bound by the big companies through lobbyist and political donations. I think that we have put ourselves at a real disadvantage as a country to be innovative and forward thinking in medicine, indeed in many areas. Small, exploratory companies like Geron are at a real disadvantage.
"never going to see $3 again" You're right! It will blow through it so fast that if you blink, you will have missed it.
Also from the report: "The safety and tolerability of imetelstat will be assessed by the incidence, nature, relatedness and severity of adverse events, laboratory abnormalities and vital signs.
Patients who develop Grade 3 or 4 cytopenias (other than lyphophenia and/or leukopenia alon) will receive addiontal safety monitoring for reversibility."
Worth noting that it is still ongoing and that the results will soon be available.
With Geron, CAUTIOUS optimism is always warranted. I wonder if there ha ever been a company with such apparent potential that has failed so many times as Geron. I'm sure that fact is one of the major reasons why we cannot gain and hold much price appreciation. Investors have been either bitten too many times, or they look at the record and decide it isn't worth the risk. What would really turn things around for us is not a "conditioned" OK by the FDA, but rather, releasing the hold and giving us special status because of the efficacy that has been demonstrated! We need something of that significance, I believe, if we are to really get things going.
Your report on durability is wonderful news. Onward and upward for you and yours, and of course, for Imetelstat, Geron, and all of us long believers.
I've read your post over several times, thanks much for that. It's very encouraging to me and should be to anyone who might have a similar question, or doubts about the status of things right now.That patent language does seem about as all inclusive as I can imagine. I too recall the controversy a few years ago about Geron inhibiting other research into telomerase through their patents. Put your post together with "Irishtrader's," and there is some really good information available here today. Hope people read it before it gets lost in the shuffle of not so useful posts.
Just listened to that story again, thanks for the reminder. You would think that, under the circumstances, Carmen's story and recordings would have gone viral. But they haven't, and perhaps that, more than anything else, explains why things are as they are.
Great post. It might be worth adding that much of the myth of the "free market" has been wrapped in the flag and presented as true Americanism, and therefore "patriotic." It all works to conceal the reality of the alignment of corporate and industrial interests with government. I go back to Eisenhower's warnings of the Military/Industrial Alliance, and suspect a similar waring is long overdue for the drug industries. Ike's warning went unheeded, too, and look where that has led us. These days, few people holding elected office are talking much at all about the relationship of government to established industries and corporations, or for that matter, the big banks. Big money has perverted the idea of America, and made it all about money. We should all read "The Grapes of Wrath." In it, when asked who is responsible, Jude answers, "It's not a who, but a what - the corporations." Today, his "what" is now a "who."
Concerning the use of human embryonic stem cells, the "what" has largely been religious objection and the politics that go along with it. Geron was working in this same area a few years ago and relocated much of their operations to Europe to escape the controversy. America doesn't readily adopt new ideas, but we eventually do - mostly. The BBC report on the Harvard story said that they hope to have these insulin producing cells available in a couple of years. We shall see.
I'll try to post the website: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2423206/
If that doesn't work, try searching for "Methods of Telomerase Inhibition, Andrews and Tollefsbol"
What concerns me is that other methods for inhibiting telomerase via TERT are being explored and seem to be advancing rapidly. As I understand things, some have very limited toxicity, or non at all. If any of you more informed people can refute this, or perhaps explain why Geron investors should not be concerned, it would be much appreciated.
I think it's pretty much following the overall rhythm of the market. Without news, there's no reason for it not to.