Gave the source see below. Just stumbled into, thought it might be a good abstract for those less familiar with RXI's development........GL
If I remember correctly Advanced and RXI have agreement per Adv given the right to market RXI's sdrxRNA for RXI for certain %. Will attempt to find this info, perhaps you will do same,,,,thnks
Completion of this project will createa foundation for developing the first line of sdRNAs based products for commercialization, which will be done as part of phase II proposal. Availability of these sdRNA reagents that are active in all cell types and in vivo will enable functional genomicsand target stratification/validation studies and have a major impact on the drug discovery process. PUBLIC HEALTH RELEVANCE: The utility of RNAi technology is severely limited by limited availability of efficient delivery of RNAi compounds to primary cells and in vivo. We have recently developed a new class of RNAi compounds, self- delivering rxRNA or sdRNA. sdRNA is a hydrophobically modified RNAi- antisense hybrid, which has been demonstrated to be highly efficacious in vitro in primary cells andin vivo upon local administration. Current proposal will focus on further optimizing this new class of compounds to enable rapid design and synthesis.
DESCRIPTION (provided by applicant): Introduction of small interfering RNAs (siRNAs) into cells with transfection reagents results in efficient gene silencing. Unfortunately, while siRNA-based functional genomics is widely used in vitro, the ability to apply this technology to primary cells and in vivo target validation has been impeded limited availability of efficient and non-toxic delivery systems. We, in collaboration with RXi Pharmaceuticals, have developed a novel class of covalently modified RNAi compounds that do not require a delivery vehicle to enter cells and have improved pharmacology compared to traditional siRNAs. We term these compounds self- delivering RNA or sdRNA. sdRNA is a hydrophobically modified RNAi- antisense hybrid, which has beendemonstrated to be highly efficacious in vitro in primary cells and in vivo upon local administration. Robust uptake and/or silencing without toxicity has been demonstrated in several tissues including dermal, muscle, tumors, alveolar macrophages, spinal cord, retina etc. In dermal layer and retina, intradermal and intravitreal injections of sdRNA at 5g doses induce potent and long lasting silencing. RXi has utilized extensive screening to successfully identify functional sdRNA compounds against a number oftargets and are actively procuring some of these compounds toward clinical development. A major hurdle to commercialization of sdRNA as a superior functional genomics tool, enabling RNAi in primary cells and in vivo, is the relatively low hit rate as compared to conventional siRNAs. While the need to screen large number of sequences per gene is not a limiting factor for therapeutic applications, it severely limits the applicability of sdRNA technology to functional genomics, where cost effective compound selection against thousands of genes is required. The objective of this proposal is to optimize sdRNA structure, chemistry, targeting position, sequence preferences to develop an algorithm for sdRNA potency predic
hanna, on the contrary, Advanced position of over 5% ownership shows very much evidence in their continued interest in RXI..................GLTA
bio, I read it as a 5.5% ownership in RXI. Unless I am mistaken Advanced % did not change as the 13g must be filed by certain dates, otherwise would we not have also seen a filing requirement of additional shares added to their position as a holder of over 5% ?. GLTA
By any chance? Just asking.................thanks, GL............
Thanks for the post. Just a note of mention IBB at its highest. Seems the trend of big pharma to go shopping for new drugs and decrease in house R&D continues, hence the highest # of developmental biotech ever..........GL
It's beginning to turn into a large position. I wish I paid more attention..................GLTA
hanna, that was Barrier you referred to I gather. Just further confirmation that Cauwenbergh knows what he is doing IMHO............GLTA
I remain bullish RXI. My reasons very evident per my input DD on the science and the management. I'll watch and stay tuned...........GLTA