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Medical Marijuana, Inc. Message Board

robvano79 393 posts  |  Last Activity: Nov 20, 2015 3:57 PM Member since: Apr 1, 2012
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  • Reply to


    by heatherp1114 Nov 20, 2015 3:41 PM
    robvano79 robvano79 Nov 20, 2015 3:57 PM Flag

    See that big block they put on 5.85?
    It's so obvious holding every shares

  • Reply to


    by heatherp1114 Nov 20, 2015 3:41 PM
    robvano79 robvano79 Nov 20, 2015 3:55 PM Flag

    Exactly Ivan
    That's why I say forget about the daily pps

  • We all know what's going on with pps so far.
    Crooks know we have a winner here..just relax and hold on to your shares .
    Let the science do all the talking..I know some of you are that bought in upper 10's are in red.
    But,in few years you will be smiling to the bank .
    Glta longs

  • Reply to

    AVXL on cbnc

    by bulltard Nov 20, 2015 2:29 PM
    robvano79 robvano79 Nov 20, 2015 3:06 PM Flag

    Please stop it
    We will get on CNBC in time
    Glta longs

  • Reply to

    Confusion over Yesterday's PR

    by ctixers_other_alias Nov 19, 2015 1:23 PM
    robvano79 robvano79 Nov 19, 2015 2:09 PM Flag

    Where is the email that you received from IR?

  • Reply to

    Confusion over Yesterday's PR

    by ctixers_other_alias Nov 19, 2015 1:23 PM
    robvano79 robvano79 Nov 19, 2015 1:27 PM Flag

    Where is the email that they sent you?

  • Reply to


    by robvano79 Nov 19, 2015 7:03 AM
    robvano79 robvano79 Nov 19, 2015 8:03 AM Flag

    Still have all my shares from .82 presplit.
    Too much upside on this one LONG TERM that is
    Hold on longs

  • robvano79 by robvano79 Nov 19, 2015 7:03 AM Flag

    NEW YORK, Nov. 19, 2015 (GLOBE NEWSWIRE) -- Anavex Life Sciences Corp. (“Anavex” or the “Company”) (AVXL), a clinical-stage biopharmaceutical company developing drug candidates to treat Alzheimer’s disease, other central nervous system (CNS) diseases, pain and various types of cancer, today announced the presentation of preclinical epilepsy data at the upcoming American Epilepsy Society Annual Meeting.

    Poster Presentation Details

    Title: Novel Anti-Seizure Compound ANAVEX 2-73 a Sigma-1 Receptor Agonist in Multiple Seizure Models

    Date/Time: Monday, December 7, 2015
    8:00 a.m. - 2:00 p.m.

    Location: Philadelphia, PA Convention Center, Hall A, 200 Level
    The American Epilepsy Society Annual Meeting takes place in Philadelphia, PA from December 4-8, 2015. Additional information is available on the American Epilepsy Society website.

    “ANAVEX 2-73 demonstrated convincing data in three well-established and predictive preclinical anti-seizure models with potentially more favorable side effect profile than currently marketed epilepsy drugs,” said Christopher U. Missling, PhD, President and Chief Executive Officer of Anavex. “The cognitive-enhancing features of ANAVEX 2-73 might be a differentiating factor since seizures cause neuro-cognitive impairments, which can be worsened by current epilepsy medications. With recent data from the Phase 2a trial for ANAVEX 2-73, the Company is encouraged to continue exploring this additional indication.”

    About Epilepsy

    Epilepsy is the most common serious neurological disorder, affecting people of all ages. It is a term used for recurring seizure disorder, a condition that is characterized by the tendency for an individual to have repeated nervous seizures (interruption of normal brain activity). Epilepsy is considered to be a spectrum disorder that can cause other health problems, including cognitive impairments, with a wide range of seizure types and control varying from person to person. The greatest unmet needs in epilepsy remain the inadequate control of seizures that occur in 20% to 30% of drug-treated epilepsy patients, effective treatments for related orphan indications like Dravet or Lennox-Gastaut Syndrome, rare forms of epilepsy, and therapies with reduced co-morbidity, translating into a significant market opportunity. The global epilepsy market was estimated at $4.2 billion in 2012 and is expected to grow to $5.35 billion by 2022, with more than 50% of sales coming from the United States.

    About Anavex Life Sciences Corp.

    Are we becoming HumanKinda?
    JetBlue Sponsor

    Anavex Life Sciences Corp. (AVXL) is a publicly traded biopharmaceutical company dedicated to the development of novel drug candidates to treat central nervous system (CNS) diseases and various types of cancer. Anavex’s lead drug candidates, ANAVEX 2-73 and ANAVEX PLUS, the combination of ANAVEX 2-73 and donepezil (Aricept®), are currently in a Phase 2a clinical trial for Alzheimer’s disease. The drug combination ANAVEX PLUS produced up to 80% greater reversal of memory loss in Alzheimer’s disease models versus when the drugs were used individually. ANAVEX 2-73 is an orally available drug candidate that targets sigma-1 and muscarinic receptors and successfully completed Phase 1 with a clean data profile. Preclinical studies demonstrated its potential to halt and/or reverse the course of Alzheimer’s disease. It has also exhibited anticonvulsant, anti-amnesic, neuroprotective and anti-depressant properties in convulsive epileptic animal models, indicating its potential to treat additional CNS disorders, including epilepsy and others. Michael J. Fox Foundation (MJFF) for Parkinson’s Research has awarded Anavex a research grant to develop ANAVEX 2-73 for the treatment of Parkinson’s disease to fully fund a preclinical study, which could justify moving ANAVEX 2-73 into a Parkinson’s disease clinical trial. Further information is available at

    Forward-Looking Statements

    Statements in this press release that are not strictly historical in nature are forward-looking statements. These statements are only predictions based on current information and expectations and involve a number of risks and uncertainties. Actual events or results may differ materially from those projected in any of such statements due to various factors, including the risks set forth in the Company’s most recent Annual Report on Form 10-K filed with the SEC. Readers are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof. All forward-looking statements are qualified in their entirety by this cautionary statement and Anavex Life Sciences Corp. undertakes no obligation to revise or update this press release to reflect events or circumstances after the date hereof.

  • Reply to

    Why even respond to Fonteneau anymore?

    by majikman474747 Nov 15, 2015 9:32 PM
    robvano79 robvano79 Nov 15, 2015 9:35 PM Flag

    He's still posting?
    He's in my IGGY BIN

  • Reply to

    Great post from hooperg83 on ihub

    by robvano79 Nov 15, 2015 7:47 AM
    robvano79 robvano79 Nov 15, 2015 2:51 PM Flag


  • Reply to

    Why the dr didn't sell at $14?

    by robvano79 Nov 15, 2015 11:44 AM
    robvano79 robvano79 Nov 15, 2015 2:48 PM Flag

    We will all look back in a few years and say why I didn't buy more
    Am I happy with the pps so far?NO
    Wish I sold some in the 14's ?YES
    But,nothing has changed so far(science)so am holding all my shares.
    I've never seen so many negative article and Bashers attacking a stock
    Glta long and hold on

  • If this was a p&d and I was the dr I would've sold at $14 and retire
    As you can see the WORMS are working hard on a weekend.
    Nothing has changed so far..hold on to your shares and ignore all the noise.
    Glta long
    Still holding here from .82 and will hold for atleast 5yrs

  • Reply to

    Great post from hooperg83 on ihub

    by robvano79 Nov 15, 2015 7:47 AM
    robvano79 robvano79 Nov 15, 2015 9:38 AM Flag

    Its all about the science

  • hooperg83 Saturday, 11/14/15 10:23:27 PM
    Re: None
    Post # of 36716
    The Science of Anavex 2-73: Part 1

    Here is a little something I am putting together to dispel some of the misinformation regarding pharmacokinetics, drug efficacy, clinical trials, and a smattering of other topics.

    Let us begin with a discussion of pharmacokinetics. In English, this is the study of how a drug is processed in the human body, which is a critical factor in both safety and efficacy.

    When a drug is administered, it can enter the body via multiple routes: by mouth (PO), intravenously (IV), intrathecal (IT), intramuscular (IM), intraosseous (IO), intraarterial (IA), inhalation, and a couple of others. For the sake of our discussion, let's consider PO only at the moment, as this is the route of administration of Anavex 2-73.

    Oral administration of a drug is undoubtedly the most convenient (and marketable!) route for the delivery of medication, as the medication can be tailored to respond to the various environments of the gastrointestinal (GI) tract. This can facilitate rapid absorption, delayed absorption, and even alterations to the original compound by enzymes of the gastrointestinal tract and/or changes in pH.

    When a compound is absorbed from the GI tract, it enters the portal venous circulation as a primary agent, which is delivered to the liver. Bioavailability determines the amount of the drug that reaches the circulation, and is important to PO medications like A2-73. The liver has a number of flexible, remarkable metabolic pathways that act to alter the chemical composition of a drug in order to prepare it for excretion. These pathways are called the Cytochrome P450 network, which has multiple subsets (I am not sure which one acts on 2-73). The primary drug undergoes transformation in these pathways and exits as a metabolite. The metabolite is a completely new drug with its own pharmacokinetic profile, ligand affinity, biologic half-life, the works.
    (Of interesting note, Venlafaxine, an anti-depressant, is metabolized to desvenlafaxine, which received an additional patent protection. They just processed the original drug outside of a human body and packaged in its own pill.. cha-ching! LOL).

    In the case of A2-73, both the compound itself and its metabolite are active agonists of the Sigma-1 receptor, though the biologic half-life of the metabolite is longer. So what is biologic half-life? When you take a pill, the indwelling drug will rise in serum concentration as it is absorbed and fall as it is processed. The very, very, very complex pharmacokinetic profile of a drug depends on many factors, including hydro/lipophilicity, the tendency of the compound to bind to serum albumin and other proteins, the strength of the intramolecular bonds, etc... but it simply boils down to the amount of time it takes for your body to eliminate 1/2 of the initial concentration. The implications of this are great: drug efficacy, side-effect profile, pregnancy classification, breast milk excretion, and alcohol/other drug interactions just to name a few. And it is a SIGNIFICANT REASON why Phase 1 and 2A results are critical. Establishing a good safety profile is a monumental leap from theory to clinic. Anavex has proven that 2-73 and its metabolite can exist within and be excreted by the human body with no (as of now) serious untoward effects. This SHOULD NOT be downplayed by critics/bashers. I will not sully this article with a certain notorious journalist's name, but describing these results as "meaningless" is a severe deviation from the truth.
    (Of further interesting note, ethanol [booze] has a zero-order metabolic kinetic profile -- it doesn't how much or little you drink, it's eliminated at a constant rate).

    With respect to efficacy, having an active compound and its metabolite in circulation seems like a bonus, assuming the primary mechanism of action is sigma-1 receptor agonism, but this too is much more complex. For a PO drug to act in the CNS, it must first cross the blood brain barrier, which is the separation of systemic circulation from the extracellular milieu that surrounds the cells of the brain. After this is completed, the compound must bind to its target receptors. Binding can be reversible, irreversible, or intermittent. Furthermore, depending on what lies downstream from the ligand/receptor interaction, binding can yield markedly different results. For example, barbiturates will bind to and potentiate GABA-A receptors, allowing the DURATION of chloride channels to remain open, whereas benzodiazepines will bind GABA-A receptors as well, and increase the FREQUENCY the channels are open. Hence, it is MUCH easier to overdose/die on barbiturates, even though the two drugs act on the same receptor!

    I specifically write this to refute Mr. Shkreli's assertion on Twitter: I shorted $AVXL - i do not believe the drug *can* work given its PK and receptor pharmacology profile. This comment in itself is incredibly vague; however, even when I had a chance to discuss it with him on Twitch, he indicated that serum concentration of the ligand was not high enough (I can't quote him directly, I forgot the exact words). Regardless, that's only a tiny fraction of the puzzle. That's like saying the Germans lost World War 2 because of soldiers!

    This brings us to where we are now: efficacy. If safety is the sweet words the FDA loves, efficacy is the key to "Big Pharma's" chastity belt. We'll conclude here, and I'll follow-up with a discussion on efficacy and validating such later.

    ** I have made every effort to be ensure accurate information of the above. If you seen any gross errors, please inform me, and I'll amend them. I am long AVXL and will continue to be unless the science/clinical results/leadership dictate otherwise.


    1. Voges O, Weigman I, Bitterlich N, Missling C, Schindler C. A Phase I Dose Escalation Study to Investigate Safety, Tolerability, and Pharmacokinetics of Anavex 2-73 in Healthy Male Subjects. Poster Presentation. CNS Summit.
    2. Anand R, Gill KD, Mahdi AA. Therapeutics of Alzheimer's Disease: Past, present, and future. Neuropharmacology, 2014; (76). 27-50.
    3. Madhura M, Banister SD, Beinat C, O'Brien-Brown J, Kassiou M. Recent Advances in the Development of Sigma-1 Receptor Ligands. Australian Journal of Chemistry, 2015; 68(4).

    -Dr. H

    Realize your trading passion with E*TRADE Pro. Visit E*

  • Reply to

    TO all the PUMPERS

    by ssilverstein52 Nov 13, 2015 3:16 PM
    robvano79 robvano79 Nov 13, 2015 3:19 PM Flag

    A LOT?of money from what?
    Being locked up in the basement lmao
    Thanks NEW GUY with 11 posts

  • robvano79 robvano79 Nov 13, 2015 3:02 PM Flag

    Am surprised no1 posted that they contacted dr oz lol

  • Reply to

    Is it bad that I want AVXL to go lower?

    by nexus186791 Nov 13, 2015 2:45 PM
    robvano79 robvano79 Nov 13, 2015 2:59 PM Flag

    No it's not :)
    Am sure every longs that believe in the science wants more cheap shares

  • robvano79 robvano79 Nov 13, 2015 2:58 PM Flag

    Am mad also,but if you believe in the science THEN THAT ALL THAT MATTERS
    I still can't believe the pps so far
    And WOW look at the BASHERS out in full force lol

  • If you're a Long term holder then NO WORRIES.
    As you can see the worms are out in full force
    Just ignore all the noise and relax.
    Data speaks for itself so far
    Glta longs

  • Reply to


    by robvano79 Aug 7, 2015 10:43 AM
    robvano79 robvano79 Nov 13, 2015 2:21 PM Flag


0.0449-0.0002(-0.44%)Nov 25 3:58 PMEST