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The Blackstone Group L.P. Message Board

rrtzrealmd 171 posts  |  Last Activity: Mar 24, 2014 11:10 AM Member since: Aug 24, 2011
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  • ...do ya'need already?...on oramed's website, they've got a "graph" that you can download from the ORMD-0801 page that shows that between 2007 and 2010, they conducted THREE phase 1 studies and FOUR phase 2 studies!...

    ...so they've ALREADY done SEVEN clinical trials???...in those THREE years???...starting SEVEN years ago???...what, were they starting a collection or something?...

    ...and then, in the past FOUR years since they last updated that "graph," they've done an additional what -- 3 or 4 MORE?...does management pay itself according to the number of studies they do or what?...

    ...and despite SEVEN YEARS and a total of AT LEAST ten studies, ALL they can present NOW is "safety data"???...

    ....sniff, sniff?...smell that?...an odor like someone cooking SCAM?!!!...

  • rrtzrealmd rrtzrealmd Feb 3, 2014 7:59 PM Flag

    ....you gotta be kidding!...AF was GENEROUS in his analysis...he didn't mention that ORMP was feeding its subjects 600 plus Units of insulin PER DAY in its trials...or that what little data they have revealed suggests that the subjects at best were absorbing LESS than ONE per cent of what they took orally...or that the cost of that dosing schedule would run into HUNDREDS of dollars per day...or that the Type 1 diabetics would STILL be required to use needles...or to a dozen other things that I've discovered researching the thing...

    ...AF was even kind enough to email the company and give them a chance to respond...if anything, you should be GRATEFUL the guy didn't rip it any worse than he did...and you notice how ORMP management has completely IGNORED the collapsing stock price resulting from their failure to provide any real data -- they've likely been too busy counting their own profits, while laughing at all the idiots that fell for the scheme...

  • Reply to

    What the hell happened?

    by franktasey Feb 3, 2014 11:54 AM
    rrtzrealmd rrtzrealmd Feb 3, 2014 12:00 PM Flag

    ...the TRUTH sucks, doesn't it?...HAW!!!...

  • rrtzrealmd rrtzrealmd Feb 3, 2014 11:58 AM Flag

    ...oh, goodness!...look!...I'm RIGHT again!...HAW!!!...

  • Reply to

    This sell off is way overdone

    by tradergater Feb 3, 2014 11:50 AM
    rrtzrealmd rrtzrealmd Feb 3, 2014 11:56 AM Flag

    ...well, considering the company's alleged oral insulin is most likely worth NOTHING and considering the thing has HOAX cum SCAM written all over it, the "selloff" will NEVER be "overdone" until the stock hits ZERO and the "company" is delisted...

  • ...I was pointing out how BOGUS this company was over a MONTH ago!...HAW!!!...

  • Reply to

    Words of advice...

    by rrtzrealmd Dec 24, 2013 12:38 PM
    rrtzrealmd rrtzrealmd Feb 3, 2014 11:37 AM Flag

    ...gee, looks like I was right, huh?...HAW!!!...

  • rrtzrealmd rrtzrealmd Jan 31, 2014 9:02 PM Flag

    ...yeah, surprise, surprise!...wonder how many Wall Street "wolves" are sitting back laughing at all the "suckers" they managed to reel in this time around...

  • Reply to

    Safety data posted in Oramed website

    by sunbienhoa Jan 31, 2014 4:11 PM
    rrtzrealmd rrtzrealmd Jan 31, 2014 8:55 PM Flag

    ...hmmmmmmm....odd, isn't it, that they post the "safety" data but NONE of the other data?...perhaps there were no adverse effects because there was no insulin aborbed...after all, we already know eating insulin is non-toxic since the GI tract simply digests it like any other protein...

    ...more humorous is to click on the link to the "Results from Ex-US Pharmacokinetic Study" which takes you to a press release from December which reveals absolutely NO DATA from the study -- just CLAIMS "patient responses positively correlated with administered doses"...gee, I wonder if the FDA will accept ORMP's word...

  • rrtzrealmd rrtzrealmd Jan 31, 2014 2:01 PM Flag

    ...worse than that, what happens if a patient develops nausea and vomiting?...develops diarrhea?...how do they adjust the dosage?...what happens if a patient has a stomach or duodenal ulcer and the full TWO HUNDRED units of insulin in EACH pill manages to gain access directly to the bloodstream?...ohhhh, I bet something bad might happen there...there's plenty of reasons why no one has been able to develop an oral insulin and why Novo, who started phase ONE trials four YEARS ago is STILL in phase ONE...

  • rrtzrealmd by rrtzrealmd Jan 31, 2014 1:53 PM Flag

    ...not only does the January 30 PR not reveal any data but check out the clinicaltrials website to see how the study was constructed...

    ...first, it involved only 30 patients distributed over THREE groups -- a control plus two different formulations of ORMD-0801...ten patients per group?...given the wide variability in insulin response in humans, you can practically guarantee that the study will not detect any significant differences..

    ...but it gets worse -- they only looked at "effect of ORMD-0801 on weighted mean night time glucose levels"...gee, I wonder what happens during the day!...

    ...worse yet, they collected data -- allegedly -- for only ONE WEEK...rather a brief period, don't you think?..

    ...and then there's this:

    "At time of randomization, patients will be treated for their diabetes by diet and exercise, or by diet, exercise and metformin ( 1000 mg/day; any type and regimen). Patients will have been on a stable regimen of metformin (defined as the same metformin dose and type) for at least 6 weeks prior to entering the placebo run-in period."

    ...presuming I'm interpreting correctly, the placebo patients got just metformin, while the experimental patients got "diet and exercise" OR "diet, exercise, and metformin"?????...well, obviously, if that's the case, then the "placebo" is decidedly NOT a "control" for the experimental groups...what makes even less sense is why bother to go through all that; why not simply take bunch of type 2 diabetics, randomly divide them into two groups and then one gets placebo while the other gets ORMD-0801?...

    ...in any case, the study looks pretty silly and whatever results they finally report is unlikely to excite anyone... well, except for naive investors -- the kind the "wolves" on Wall Street love to prey upon...

  • ...google "Ehud Arbit, M.D." -- Oramed's "Director of Research and Development"...first, he's neurosrgeon, and you gotta wonder what does a neurosurgeon know that qualifies him to direct r&D for insulin therapy...

    ...but more important is his HISTORY!...He "was sanctioned by the state and fired from Memorial Sloan-Kettering Cancer Center in 1995 after operating on the wrong side of the brain of a female patient" per the New York Post...hey, can the guy help it if he's dyslexic?!!...HAW!...

    ...then, in 1998, "the state Board of Professional Medical Conduct found Dr. Ehud Arbit guilty of gross negligence for operating on the wrong" cervical disc -- per the "Office of Professional Medical Conduct
    New York State Department of Health" documents:

    "The Committee found that that Respondent [Ehud Arbit] acted unreasonably in operating at the C5-C6 disc and failed to perform surgery at the C6-7,following an evaluation and a review on a Magnetic Resonance Imaging (MRI) othe Patient’s cervical spine. On the date for the surgery, the Respondent operated instead on the decompression at level C5-C6 and failed to perform surgery at C6-C7..."...well, ya'know if they'd let him take his shoes off, he probably could've figured it out...

    Then, per NY Times, "a third case involved a patient requiring spinal surgery. An anesthesiologist and a physician's assistant told Health Department investigators that Dr. Arbit's hand slipped and lacerated the patient's spinal cord, leaving her partly paralyzed..." AND in the final case, ...a patient complained of weakness in her hands after an operation. A CAT scan revealed loose screws on a plate that had been implanted in the patient's spine along the back of the neck, the state noted. Dr. Arbit failed to replace the screws properly, the state said, at one point asking a representative from a medical equipment company his opinion on whether he thought the plate was positioned correctly."

    Alll I can say is -- HAW, HAW, HAW, HAW, HAW, HAW, HAW!!

  • rrtzrealmd by rrtzrealmd Jan 28, 2014 6:37 PM Flag

    ...looking at the data from ORMP's Type 1 study, it appears that a dose of their "oral" insulin was able to reduce glucose levels by about 80-100 after a meal...since 1 unit of insulin can be expected to reduce sugar by 30-50, that means a patient must have aborbed about 2 units...

    ...hmmmmmmmm...since each ORMD-0801 pill contains EIGHT HUNDRED units of insulin, that translates into an efficiency of absorption around 2.5%...in other words, about 98% of the dose is eventually flushed down the toilet!...

    ...with insulin costing about $150 per 1000 units, and a patient usually taking 3 doses per day, that translates into a daily cost of $400-500 per day...given the efficiency of absorption, therefore, the patient gets about $8-10 worth of insulin, while the sewer gets around $490...that's per DAY...per month it's almost $15,000 going to the closest seawage treatment...talk about expensive "sh_t"!...HAW!!!...

  • Reply to

    HAW!! Just gotta love it...

    by rrtzrealmd Jan 28, 2014 12:23 PM
    rrtzrealmd rrtzrealmd Jan 28, 2014 6:01 PM Flag

    ....uhhhh, excuse me?...WHAT "increased knowledge" are you referring to?...consider that Oramed's pill contains EIGHT HUNDRED units of insulin and that it's taken THREE times a day...that's a total dose of TWO THOUSAND FOUR HUNDRED UNITS per DAY!...with insulin running around $150 per thousand unite, it would cost a patient between four and five HUNDRED dollars a DAY...or fifteen THOUSAND dollars per MONTH!...gee, with "increased knowledge" like that, we oughta go broke in no time at all!...HAW!!!...

    ...not to mention that Type I diabetics would STILL have to continue to use a needle -- some help "increased knowledge" does them!...HAW!!!...

    ...besides, Miriam has ALREADY shown the safety and effectiveness of Emisphere's and Generex's oral insulins -- WHY, exactly, do we need another?...

    .

  • ...I mentioned in an earlier post how Miriam Kidron -- the CEO's mother -- had once been employed as an adviser to Emisphere on THEIR oral insulin and how EMIS' stock price of around 20 CENTS a share indicates what an effective adviser she was!...then what do I do but turn around and read that she was ALSO adviser to -- hold on to your seats now! -- "GENEREREX BIOTECHNOLOGY"!!!...

    ...yes, that's right!...Miriam advised Genererex in the development of their "blockbuster drug" -- SARCASM,SARCASM,SARCASM!!! -- "ora-lyn" -- yet ANOTHER fine oral insulin!!!...please hold while I relieve myself:

    HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW!!!!

    ...and what did Miriam have to say about "ora-lyn":

    "In this study in a small, selected population of healthy male subjects under euglycemic conditions, oral insulin spray was associated with a higher Cmax, shorter Tmax, and faster time to peak glucose uptake compared with SC insulin. The short Tmax and the 120-minute duration of effect of oral insulin spray suggest it may be a promising alternative for fulfilling meal-related insulin requirements in persons with diabetes."

    ...hey!...nothing breeds success like success, huh?!...okay, let's see, GNBT now trades around a NICKEL a share!...a nickel?????...hmmmmmmmmm....repeat for extra gravity -- hmmmmmmmmm...and now she's advising ORMP?...wait for it...............hold on...................just a litle longer.................................okay -- now:

    HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW,!!!!!!!

  • rrtzrealmd by rrtzrealmd Jan 28, 2014 11:52 AM Flag

    ...SPE dropped to aaround 1 15-20% discount to NAV this am after they annoinced redemption of the convertible pfd...I guess people are afraid the holders will turn around and dump the stock but I think they're nuts...redeeming the convert makes more cash available to the common holders and the managers of the fund have aptly demonstrated their prowess at investing since they took it over...they also have a history of buying in stock whenever the discount gets enlarges...looks like a great opportunity to me...

  • Reply to

    Gotta laugh at this joke of a company...

    by rrtzrealmd Jan 27, 2014 12:59 PM
    rrtzrealmd rrtzrealmd Jan 27, 2014 8:47 PM Flag

    ...you should refrain from displaying such gross ignorance -- it identifies you as a "typical" biotech investor...insulin is not injected into the "bloodstream," but into subcutaneous fat...there is absolutely ZERO evidence to prove that oral insulin would in ANY way be superior in outcome either short or long-term to injected insulin...and bear in mind, Novo started their phase 1 studies FOUR YEARS ago and is STILL there...also note what the CEO's mother wrote ten YEARS ago when she was acting as advisor to Emisphere:

    "Miriam Kidron, Ph.D., Senior Researcher, Diabetes Unit, Hadassah University Hospital in Israel, presented a poster in the late-breaking session of the Scientific Sessions evaluating EMISPHERE oral insulin with an EMISPHERE delivery agent at bedtime (Abstract# 12-LB)...This study evaluated the overnight effects of an oral insulin prototype in 20 type 2 diabetic patients, who were given oral insulin at bedtime... Dr. Kidron commented on the study, stating, "These data, which are noteworthy, suggest that not only did the insulin get to the right place at the right time because of successful oral delivery, but that the amount delivered was effective for a long enough period to decrease the burden placed on the pancreatic cells, a problem that perpetuates the progression of type 2 diabetes. The results suggest that Emisphere's oral insulin, while being a convenient option as an oral therapy, also has the potential as a first line therapy to slow the progression of type 2 diabetes by improving the longevity of insulin producing cells."

    ...now go take a look at Emisphere's stock -- tells you evrything you need to know...

  • ...from the company's website:

    "Oramed proposes to introduce ORMD-0801 treatment as a complementary agent to insulin injections in the treatment of T1DM."

    ...given that Type 1 diabetics require relatively small amounts of insulin -- typically 30U or less per day -- and given that the MASSIVE dose of 8 MILLIGRAMS in each ORMD0801 pill amounts to about 800U -- got that, eight HUNDRED UNITS of insulin in EACH pill -- they are basically admitting that their pill is INEFFECTIVE...

    ...if the patient STILL has to take shots in order to get adequate insulin levels DESPITE taking orally TWO THOUSAND FOUR HUNDRED units of oral insulin a day -- as reported in ORMP's Type 1 study -- then what good is it?...

    ...but what is even more hilarious is this:

    "Oramed's oral insulin is indicated for the earlystages of T2DM, when it can still slow the rate of degeneration of the disease by providing additional insulin to the body and allowing pancreatic respite."

    ...they try and argue that providing exogenous insulin allows the T2DM patient's pancreas to "rest"...well, that's nice but, unforunately, that's NOT the PROBLEM initially -- the problem is insulin resistance due to bloated fat cells with inadequate insulin receptors!...

    ...not to mention that insulin therapy in type 2 diabetics usually starts around 50U a day...even if ORMP's idea had any merit, how many units of oral insulin would be required per day to reach theraputic levels levels -- probably something well in excess of 3-4 THOUSAND units per DAY!...Humulin r runs around $140 per day, so Orascam's pill would probably have to cost somewhere north of FIVE HUNDRED dollars per DAY!!...

  • Reply to

    AFOP or A-FLOP?

    by brgolfer61 Jan 27, 2014 10:34 AM
    rrtzrealmd rrtzrealmd Jan 27, 2014 11:11 AM Flag

    ...earnings report due this week -- some probably cashing out ahead just as a precaution...also consider that a year ago it was trading around $6 -- a 100 plus per cent gain in a year is nothing to sniff at...company has 3-4 bucks a share in cash and investments...still has a strong relative strength...technically appears to have support at $13-14...I'm keeping an eye on it and may go ahead and nibble a bit...but market has been acting increasingly "stupid" for several months -- stupid as in junk stocks hitting new highs with increasing volumes -- so I'm not inclined to be aggressive until I get a better idea of how this correction plays out...

  • Reply to

    Went ahead and bought some...

    by rrtzrealmd Jan 24, 2014 12:14 PM
    rrtzrealmd rrtzrealmd Jan 27, 2014 10:52 AM Flag

    ..."how do you buy it for $2 a share"??????...well, I didn't...per the company's last 10Q, THEY had $2 in cash per share and -- as I recall -- were cash flow positive...to me it was a decent value/growth speculation...I paid about $7.60 a share for an opening position and I'm waiting for the earnings report -- due I think within the next couple of days -- to see if it still merits my assessment...

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