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The Blackstone Group L.P. Message Board

rrtzrealmd 171 posts  |  Last Activity: Mar 24, 2014 11:10 AM Member since: Aug 24, 2011
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  • ...to wait until AFTER the close to make the announcement?...now longs get to sit up alllllllll night just wondering how bad their own personal buttrape is going to be tomorrow!...HAW!!!...

    ...but will the financial guillotine cause management lose any sleep?...why, no, of course not!...

    ...the cash they brought in from that 10 MILLION share secondary back in December ought to keep their FAT salaries,benefits, bonuses, and perks funded for at least another year!...

    ...sure, they may shed a "crocodile tear" or two, but deep down they'll be fat and happy, while all the BAGHOLDERS are out making cardboard signs saying, "will work for food"...HAW!!!...

    ...and by the time the money starts to run out in a year or so, everyone will have forgotten this FAILURE, and XOMA will be able to start the whole con allllllll over again!...

    ...ain't biotech GRAND!...HAW, HAW, HAW!!!!...

  • Reply to

    From a diabetes doctor

    by doctor.chicago Feb 4, 2014 2:59 PM
    rrtzrealmd rrtzrealmd Feb 4, 2014 7:07 PM Flag

    ...I'd say most likely it's "Dr. Bagholder"!...HAW!!!...

  • ...from the company's website:

    "Oramed proposes to introduce ORMD-0801 treatment as a complementary agent to insulin injections in the treatment of T1DM."

    ...given that Type 1 diabetics require relatively small amounts of insulin -- typically 30U or less per day -- and given that the MASSIVE dose of 8 MILLIGRAMS in each ORMD0801 pill amounts to about 800U -- got that, eight HUNDRED UNITS of insulin in EACH pill -- they are basically admitting that their pill is INEFFECTIVE...

    ...if the patient STILL has to take shots in order to get adequate insulin levels DESPITE taking orally TWO THOUSAND FOUR HUNDRED units of oral insulin a day -- as reported in ORMP's Type 1 study -- then what good is it?...

    ...but what is even more hilarious is this:

    "Oramed's oral insulin is indicated for the earlystages of T2DM, when it can still slow the rate of degeneration of the disease by providing additional insulin to the body and allowing pancreatic respite."

    ...they try and argue that providing exogenous insulin allows the T2DM patient's pancreas to "rest"...well, that's nice but, unforunately, that's NOT the PROBLEM initially -- the problem is insulin resistance due to bloated fat cells with inadequate insulin receptors!...

    ...not to mention that insulin therapy in type 2 diabetics usually starts around 50U a day...even if ORMP's idea had any merit, how many units of oral insulin would be required per day to reach theraputic levels levels -- probably something well in excess of 3-4 THOUSAND units per DAY!...Humulin r runs around $140 per day, so Orascam's pill would probably have to cost somewhere north of FIVE HUNDRED dollars per DAY!!...

  • ...a two bit biotech -- two bits actually being a very generous assessment of the value of its stock -- goes out and commits to spending 52 million dollars -- even though they're probably near broke -- to buy a company that likely has less than 10 million in revenues -- given that either no one uses the drugs they offer or else there's maybe only 20-30 patients with a disease the drug can treat...

    ...is that about the size of it?...hold on a second while I get this off my chest:

    HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW!!!!

    ...whew!...I feel much better now!...

    ...well, let's see, per the last 10Q, RTRX lost 20 MILLION dollars in the preceding nine months -- typical biotech...ten MILLION of that was in just the preceding three months -- probably issuing bonuses to management...about 15 mil in cash at the time -- but burning 3-4 million a month means by NOW they must be just about BROKE!!!...

    ...why, makes perfectly good sense!...broke, losing money hand over fist, no prospects for improving cash flow anytime in the near future -- how are we going to justify a SECONDARY OFFERING?...

    ...oh, wait!!...I know!...I know!!!...call on me!!!...ahem!...let's go out and spend a fortune buying another near worthless company!...that'll justify a SECONDARY and let us rake in some extra cash just in time for BONUSES!...there's a motion on the floor -- all approving say, "aye"!...AYE, AYE, AYE!!!!!!!!!!...the motion is carried!...now, excuse me, I have to run down and pick out a color for my new Mercedes...HAW!!!!!...

  • rrtzrealmd by rrtzrealmd Jan 28, 2014 6:37 PM Flag

    ...looking at the data from ORMP's Type 1 study, it appears that a dose of their "oral" insulin was able to reduce glucose levels by about 80-100 after a meal...since 1 unit of insulin can be expected to reduce sugar by 30-50, that means a patient must have aborbed about 2 units...

    ...hmmmmmmmm...since each ORMD-0801 pill contains EIGHT HUNDRED units of insulin, that translates into an efficiency of absorption around 2.5%...in other words, about 98% of the dose is eventually flushed down the toilet!...

    ...with insulin costing about $150 per 1000 units, and a patient usually taking 3 doses per day, that translates into a daily cost of $400-500 per day...given the efficiency of absorption, therefore, the patient gets about $8-10 worth of insulin, while the sewer gets around $490...that's per DAY...per month it's almost $15,000 going to the closest seawage treatment...talk about expensive "sh_t"!...HAW!!!...

  • ...did someone finally realize the company didn't know that ONE international unit equals .03846 milligrams of insulin, NOT 45.5 milligrams -- which means that their 8 mg pill contains 208 units of insulin and dosing three times a day would consume 624 units -- enough insulin to keep a typical type 1 diabetic supplied for three WEEKS!...and which would cost -- at current insulin prices -- somewhere in the neighborhood of $100 per day?!...

    ...and the type 1 diabetics would STILL have to use needles three times a day ANYWAY?!...

    ...I'm surprised the thing hasn't dropped to ZERO!

  • ....some sort of "nanoSCAMacide" that would kill of companies like NNVC...then again, that would probably wipe out probably 95% of the biotechs currently trading and send who knows how many brokers into the unemployment lines...

    ...seriously, this thing stinks worse than a Bollywood movie, which, judging by management, it practically is:

    "Pursuant to an Exclusive License Agreement we entered into with TheraCour Pharma, Inc., (TheraCour), the Company was granted exclusive licenses in perpetuity for technologies developed by TheraCour for the virus types: HIV, HCV, Herpes, Asian (bird) flu, Influenza and rabies. In consideration for obtaining this exclusive license, we agreed: (1) that TheraCour can charge its costs (direct and indirect) plus no more than 30% of direct costs as a Development Fee and such development fees shall be due and payable in periodic installments as billed, (2) we will pay $25,000 per month for usage of lab supplies and chemicals from existing stock held by TheraCour, (3) we will pay $2,000 or actual costs, whichever is higher for other general and administrative expenses incurred by TheraCour on our behalf, (4) make royalty payments (calculated as a percentage of net sales of the licensed drugs) of 15% to TheraCour Pharma, Inc. and (5) agreed that TheraCour Pharma, Inc. retains the exclusive right to develop and manufacture the licensed drugs. TheraCour Pharma, Inc. agreed that it will manufacture the licensed drugs exclusively for NanoViricides, and unless such license is terminated, will not manufacture such product for its own sake or for others...

    ...TheraCour owns 33,360,000 shares of the Company’s outstanding common stock as of December 31, 2012."...Anil R. Diwan, President, and a director of the Company, is also a Director and President of TheraCour. Dr. Diwan owns approximately 70% of the common stock of TheraCour..."

    ...seriously?????...and the SEC allows nonsense like this?!...I simply must start my own biotech firm!

    Sentiment: Strong Sell

  • ...I mentioned in an earlier post how Miriam Kidron -- the CEO's mother -- had once been employed as an adviser to Emisphere on THEIR oral insulin and how EMIS' stock price of around 20 CENTS a share indicates what an effective adviser she was!...then what do I do but turn around and read that she was ALSO adviser to -- hold on to your seats now! -- "GENEREREX BIOTECHNOLOGY"!!!...

    ...yes, that's right!...Miriam advised Genererex in the development of their "blockbuster drug" -- SARCASM,SARCASM,SARCASM!!! -- "ora-lyn" -- yet ANOTHER fine oral insulin!!!...please hold while I relieve myself:

    HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW!!!!

    ...and what did Miriam have to say about "ora-lyn":

    "In this study in a small, selected population of healthy male subjects under euglycemic conditions, oral insulin spray was associated with a higher Cmax, shorter Tmax, and faster time to peak glucose uptake compared with SC insulin. The short Tmax and the 120-minute duration of effect of oral insulin spray suggest it may be a promising alternative for fulfilling meal-related insulin requirements in persons with diabetes."

    ...hey!...nothing breeds success like success, huh?!...okay, let's see, GNBT now trades around a NICKEL a share!...a nickel?????...hmmmmmmmmm....repeat for extra gravity -- hmmmmmmmmm...and now she's advising ORMP?...wait for it...............hold on...................just a litle longer.................................okay -- now:

    HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW, HAW,!!!!!!!

  • Reply to

    Gotta laugh at this joke of a company...

    by rrtzrealmd Jan 27, 2014 12:59 PM
    rrtzrealmd rrtzrealmd Jan 27, 2014 8:47 PM Flag

    ...you should refrain from displaying such gross ignorance -- it identifies you as a "typical" biotech investor...insulin is not injected into the "bloodstream," but into subcutaneous fat...there is absolutely ZERO evidence to prove that oral insulin would in ANY way be superior in outcome either short or long-term to injected insulin...and bear in mind, Novo started their phase 1 studies FOUR YEARS ago and is STILL there...also note what the CEO's mother wrote ten YEARS ago when she was acting as advisor to Emisphere:

    "Miriam Kidron, Ph.D., Senior Researcher, Diabetes Unit, Hadassah University Hospital in Israel, presented a poster in the late-breaking session of the Scientific Sessions evaluating EMISPHERE oral insulin with an EMISPHERE delivery agent at bedtime (Abstract# 12-LB)...This study evaluated the overnight effects of an oral insulin prototype in 20 type 2 diabetic patients, who were given oral insulin at bedtime... Dr. Kidron commented on the study, stating, "These data, which are noteworthy, suggest that not only did the insulin get to the right place at the right time because of successful oral delivery, but that the amount delivered was effective for a long enough period to decrease the burden placed on the pancreatic cells, a problem that perpetuates the progression of type 2 diabetes. The results suggest that Emisphere's oral insulin, while being a convenient option as an oral therapy, also has the potential as a first line therapy to slow the progression of type 2 diabetes by improving the longevity of insulin producing cells."

    ...now go take a look at Emisphere's stock -- tells you evrything you need to know...

  • rrtzrealmd rrtzrealmd Feb 14, 2014 12:31 PM Flag

    ...well, so far they've only shown it works in MICE that have been treated to MIMIC a PKAN phenotype...and there is a WIDE gulf -- think in terms of the distance from earth to "z8_GND_5296" -- between some poisoned varmint and a real live human being with a true genetic abnormality...you might want to consider that before believing that some hedge fund manager is going to be able to pull a magic rabbit out of his hat...

  • Reply to

    Will wonders ever cease...

    by rrtzrealmd Feb 14, 2014 1:48 AM
    rrtzrealmd rrtzrealmd Feb 14, 2014 1:51 AM Flag

    ...oops!...my mistake!...they're actually spending 62 MILLION -- not 52 million...sorry, I was laughing so hard, the tears must have obscured my vision...

  • Reply to

    460 units of insulin per meal???

    by rrtzrealmd Feb 10, 2014 12:59 PM
    rrtzrealmd rrtzrealmd Feb 10, 2014 1:33 PM Flag

    ...Henry Schein charges $145 for 1000U of Humulin R --- that price is to hospitals and docs; I don't know what consumers have to pay...so figure the 460 units Oramed gave as costing around $70...if required to take three times a day, you get around $200...bear in mind that insulin dosing varies widely -- ranging usually from 30U per day to 70U in type 1 diabetics and 50U plus in type 2 diabetics...

    ...note that Oramed NEVER discusses this issue ANYWHERE -- they NEVER point out how many UNITS they are actually giving...they NEVER point out that what little data they offer in their trials suggests less than 1% absorption -- indeed, they NEVER discuss the efficiency of absorption at all...they NEVER mention the cost of the insulin being given...I'm really amazed at their audacity -- to claim they have an oral insulin and then put out PRs about releasing data -- but NOT release it -- and more PRs about trials -- despite the TEN or so "trials" they've already done...etc, etc...they make Generex look like a piker in terms of dis/mis-information...

    ...I know of no other mistakes, but I'm going to look at those two reports from their wesite again...I sort of skimmed the first time through because they were both clearly useless studies in terms of design -- that and the absurd amount of insulin in each pill -- they just weren't worth the effort...

  • Reply to

    31 to 10.

    by jk4763 Mar 17, 2014 1:35 PM
    rrtzrealmd rrtzrealmd Mar 19, 2014 7:41 PM Flag

    ...hey, look at the bright side!...given that its REAL value is about the same as that of a piece of used toilet paper, that it's trading at $10 is a testament to the ability of stockbrokers to walk on water!...

    ...an ORMP shareholder prayer:

    "Hail Goldman, full of salesmen, money is with thee, blessed art thou amongst brokers, and blessed is the fruit of thy womb, big bonuses!, Holy Sachs, Mother of wealth, pray for us BAGHOLDERS, now and at the hour of our chapter 11 filing, amen!"

    ....HAW!!!!....

  • rrtzrealmd rrtzrealmd Jan 23, 2014 7:54 PM Flag

    ...sometimes it's what they DON'T mention that counts...for example, they DON'T mention that so far they haven't done ANY studies where patients take ONLY the pill...in every study I saw, the patients CONTINUE, while on the study, to use their needles to inject their regular dosage of insulin...what benefit is there if the patients just have to use their needles anyway?...

  • ...I read the PR about the "protocol" ORMP allegedly has prepared for a phase 2 study on type 1 diabetics...I posted previously about the results of the type 1 study they posted on their website...I hate to admit it but I made a mistake...I reread it and noticed that, contrary to what I posted previously, they actually gave TWO ORMD-0801 pills before the meal...

    ...bear in mind that insulin is usually dosed in UNITS, and that each Oramed pill has 8 mg or about 230 UNITS of insulin...so, prior to the meal, they actually gave FOUR HUNDRED AND SIXTY units to EACH trial subject!!!...

    ...do you have ANY idea how much that is?...a typical type 1 diabetic on average takes around 50 units -- give or take -- per DAY!...read that again -- 50 units per DAY!...in other words, at ONE meal, Orascam gave TEN TIMES what a type 1 diabetic takes per DAY!...

    ...worse yet, when you look at the data in that study, it indicates glucose dropped by about 100...well, ONE unit of subQ insulin will cause a drop of about 50...therefore, it appears that Oramed MIGHT have gotten absorption of TWO units...TWO UNITS out of FOUR HUNDRED AND SIXTY!!!...given that a 1000 units sells for around $150, that means that roughly $75 worth of insulin was WASTED!...

    ...if used three times a day, that would be $225 totally WASTED!...talk about expensive meals!...HAW!...

    ...not to mention that the type 1 diabetics will STILL have to continue using their needles -- unless, of course, they were willing to take FIFTY some odd pills a day!...HAW!!...

    ...even ignoring that all these piddly little "trials" have a somewhere near absolute ZERO chance of impressing the FDA, I can only conclude that ORMP is an total #$%$ joke!...HAW!!!...

  • rrtzrealmd by rrtzrealmd Feb 20, 2014 12:53 AM Flag

    ...I noticed that less than two WEEKS after announcing "positive results" from its OMS824 phase TWO trial, gOMER turned around and announced "further positive data from the OMS824 phase ONE trial...

    ...however, the only thing "new" to me was this line:

    "Since the maximally tolerated dose has not been reached, Omeros is now planning to evaluate a higher dose of OMS824 in the trial to determine whether an even higher level of PDE10 occupancy can be achieved."

    ...but, gee, gOMER, you've ALREADY finished a phase TWO trial and NOW you're going BACKWARDS "to evaluate a higher dose"?...why?...

    ...especially AFTER you've already announced "positive results" from phase TWO????...

    ...oh, wait!...I almost forgot -- those "positive results" did NOT include efficacy!...ahah!...of course, THEY blamed that result on the "small sample size" (muffled snicker at this point)...still, announcing more phase ONE studies in search of a higher dose AFTER the phase TWO announcement kinda hints that the drug DID NOT WORK!...

    ...everyone got that -- DID NOT WORK!...in fact, it apparently DID NOT WORK to such an extent that they weren't even willing to expose the data to public analysis!...heck, for all we know that "efficacy conclusions cannot be drawn" may hide data suggesting the patients got WORSE!...

    ...then again, I suppose one must remember you're dealing with a company that won't reveal how many milliliters of its eye irrigation fluid a typical lens replacement might require -- hint: watch one on youtube (there are a bunch) and see how long one usually takes and guess as to how much irrigation fluid is used...

  • rrtzrealmd by rrtzrealmd Feb 20, 2014 10:03 AM Flag

    ...STRT jumped six points yesterday and ARII up five bucks as I type this...I love it when old fashioned fundamental anlysis works!...

  • Reply to

    No, this is the bottom line...

    by thinking_about_it Jan 21, 2014 1:04 PM
    rrtzrealmd rrtzrealmd Jan 21, 2014 7:36 PM Flag

    ..."They know how to sell shares and make promises. That's about it."????...well, after all, it is a biotech -- what more could you possibly expect?...it's just another stupid biotech trick with a line that brokers can pitch to the naive and ignorant and that traders can "play" with...and it needs the money to fund its obligations to Theracour which -- surprise, surprise! -- is owned by NNVC's CEO!...and the wheels on the biotech bus go round and round...round and round...

  • rrtzrealmd rrtzrealmd Feb 14, 2014 11:40 AM Flag

    ...HAW!!!...you posted the same thing TWICE in a row????...what was the matter -- upset by something I said?...gee, bagholders sure are a sensitive bunch!...HAW!!!...

    ...I suppose IGNORING the 1 for 10 reverse split allows you to say that -- in ONE sense -- no one ever paid over a $100...but the FACT remains that ONE share bought at the high of the year 2000 has LOST -- calculator please! -- 99.8 per cent of its value!...

    ...of course, that's "if one stupidly" bought the thing in the first place!!...and THEN "held on"...HAW!!!!...

  • rrtzrealmd rrtzrealmd Feb 14, 2014 8:33 PM Flag

    ...PLEASE IGNORE my previous post which is about RE-021and FSGS, NOT about RE-024 -- which is aimed at PKAN...

    ...in answer to your question.RE-024 apparently has undergone NO human studies yet...

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