Do not dither. J & E has kept us here and Jonhs Hopkins views solidfy further. No short or hedgie can shake us at least until we get to ADRO evaluation.
Cancer vaccines are not far behind, however. We can expect to see encouraging results from studies using cancer vaccines, such as the attenuated Listeria monocytogenes vaccine engineered to express human mesothelin, in pancreatic cancer and mesothelioma, Pardoll adds.
Given that the overall response rates with immunotherapy based on immune checkpoint inhibitors is around 20 percent, Pardoll says, “we still have a long way to go.” However, he also reminds us that the overall impact of immunotherapy as measured in years of cancer remission is about 30 times greater than that of all of oncogene mutation-targeted therapies combined.
The key to improving outcomes with immunotherapy lies in identifying the right patients for the right treatment. We can expect to see significant development on PD-L1 biomarker tests that can identify patients most likely to benefit from anti-PD-1/PD-L1 drugs, and lots of discussions around how to use these tests, says Pardoll. Another concept that we may hear more of in 2015, according to Pardoll, is adaptive resistance. PD-L1 expression by tumor cells suggests that a patient has an extant antitumor immune response. If a patient’s immune system does not have a strong enough antitumor response to induce PD-L1, a therapeutic maneuver to induce an antitumor immune response or amplify a weak one, such as a vaccine, will upregulate PD-L1. “So, one of the hot areas you’re going to see in 2015 is combinations of tumor vaccines with anti PD-1/PD-L1 drugs,” says Pardoll. “Combinations of checkpoint inhibitors will also be big in 2015,” he adds.
“I think that 2015 is going to be the year when you begin to see some of the first information about combinations of checkpoint inhibitors with targeted therapies, besides cancer vaccines. With combination therapies, we will have the opportunity to capture a larger number of patients into more durable response rates,” says Pardoll.
“With increasing momentum and interest from the investment community, 2015 is highly likely to be another exciting year for cancer immunotherapy,” Pardoll predicts.
Cancer immunotherapy is in the midst of an incredible growth spurt. I think there’s no reason to imagine that that’s not going to continue in 2015,” says Drew Pardoll, MD, PhD, professor of oncology, medicine, and pathology and co-director of the Cancer Immunology and Hematopoiesis Program at Johns Hopkins University. “This year will be the year in which anti-PD-1/PD-L1 immunotherapies—the immune checkpoint inhibitors—will be approved for a broad number of cancer types within one year of its first approval for melanoma,” he predicts.
The PD-1 checkpoint inhibitor, pembrolizumab, was approved by the FDA for the treatment of advanced melanoma in September 2014, which was followed by the approval of a similar drug, nivolumab, in December last year. Pardoll, who is also a senior editor of the AACR journal Cancer Immunology Research, foresees the approval of immune checkpoint inhibitors for lung, bladder, kidney, and head and neck cancers, as well as Hodgkin lymphoma, in 2015.
The next big thing to expect in immunotherapy this year is a lot of clinical trial activity and results with therapies using genetically modified T-cells, so-called chimeric antigen receptor T cell (CAR-T cell) therapies, says Pardoll. Cancer vaccines are not far behind, however. We can expect to see encouraging results from studies using cancer vaccines, such as the attenuated Listeria monocytogenes vaccine engineered to express human mesothelin, in pancreatic cancer and mesothelioma, Pardoll adds.
.hakihika around 10.40 AM on 04/22/2013
$ADRO weakness continues + $ADXS sentiment at rather extreme levels. Green to Red after 4%? Will that be enough to break the bull s back?
.. stocktwits 1 hour 14 minutes ago .