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Geron Corporation (GERN) Message Board

ryanvball1 69 posts  |  Last Activity: Sep 9, 2014 9:15 PM Member since: Nov 6, 2013
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  • Reply to

    i think it's time to buy

    by bjlikey Sep 9, 2014 12:29 PM
    ryanvball1 ryanvball1 Sep 9, 2014 9:15 PM Flag

    BJ is a short.
    By the way, the shorts made money today.
    Iggy and gone

    Sentiment: Buy

  • Reply to

    Zack's garbage

    by eireamerica Sep 9, 2014 6:21 AM
    ryanvball1 ryanvball1 Sep 9, 2014 9:15 AM Flag

    Yes correct you smart Beaver. SA is Copied and re-posted since Yahoo wont do it.
    XhtXtp:X//seXekiXngalXpha.coXm/articXle/2463965-geroXn-best-buy-in-the-maXrketX
    Take out X
    Ry

    Sentiment: Buy

  • Reply to

    Zack's garbage

    by eireamerica Sep 9, 2014 6:21 AM
    ryanvball1 ryanvball1 Sep 9, 2014 8:56 AM Flag

    Yes correct you smart Beaver. SA is Copied and re-posted since Yahoo wont do it.
    XhtXtp:X//seXekiXngalXpha.coXm/articXle/2463965-geroXn-best-buy-in-the-maXrketX
    Take out X
    Ry

    Sentiment: Buy

  • Reply to

    Very Fine New SA Article

    by end2war Sep 2, 2014 4:10 AM
    ryanvball1 ryanvball1 Sep 3, 2014 7:31 AM Flag

    I read the article and think it is one of the best written articles on any stock I have ever seen. No pump, just facts. I wondered if all is so good, why is there a hold. Now the article makes me think that possibly the delay of the release is to set up perfectly for BTD? It didn't say that, but that is now what I'm guessing.
    P, you nailed it buddy!

    Sentiment: Buy

  • Reply to

    Dr. Snyder

    by ozzie_ozborne Aug 28, 2014 4:56 PM
    ryanvball1 ryanvball1 Sep 3, 2014 7:25 AM Flag

    Direct and to the point.
    I agree!

    Sentiment: Buy

  • Reply to

    Minute 21:50

    by ptennisany1 Aug 27, 2014 4:49 PM
    ryanvball1 ryanvball1 Aug 28, 2014 8:42 AM Flag

    End, sometimes you really disappoint me. "What a pity, but I don't think Dr. Snyder offered a precisely correct response, and he should have included CIs."??
    So, you, some obscure message board writer, knows more about a private trial than a DOCTOR THAT WORKS WITH BOTH GERON AND TEFFERI AND TREATS PATIENTS IN THESE DISEASES AND DISCUSSES DETAILS WITH BOTH????

    You know more than Snyder?
    Are you serious????

    You add some good points here and there but honestly you think way too much about yourself.

    More - " I don't think the GERN lawyers would write "clinical benefit" if they understood that only those with CRs or PRs could continue. " End, THAT WAS WHAT THE FDA SAID. PERIOD.
    It was simply up to Tefferi and Mayo (Not Snyder, not Geron and not you) to determine what exactly "clinical benefit" was. Also, if I recall correctly, the word from FDA said it was up to Tefferi's opinion. My guess (and it is a GUESS) is that Mayo and Tefferi decided to be conservative and went with PR and CR (yes I thought CIs would be included, and maybe they were, but it doesn't look that way now).

    You can and should assume what YOU want and I will try to use facts as I see them.

    This is FANTASTIC news. There is no other way to look at it. Even if we look conservatively, almost all are in remission. If we take Snyder, a Yale grad and Harvard Med school guy (so I assume he is just a tad smarter than you, End) at his word, and scientists and doctors tend to use exact terminology, then ALL are in remission. END of story...

    I agree. BUY BUY BUY

    Sentiment: Buy

  • Reply to

    Minute 21:50

    by ptennisany1 Aug 27, 2014 4:49 PM
    ryanvball1 ryanvball1 Aug 27, 2014 6:17 PM Flag

    This might be the most important post I have read in a month!!!
    WOW
    Nice job P

    Sentiment: Strong Buy

  • ryanvball1 ryanvball1 Aug 19, 2014 9:52 PM Flag

    Amen

    Sentiment: Buy

  • Reply to

    Take a breath

    by ryanvball1 Aug 13, 2014 8:41 AM
    ryanvball1 ryanvball1 Aug 19, 2014 8:06 AM Flag

    Does anyone notice that in regards to the IND transfer that all it says is that Geron will "contact" the FDA and inform them on any moves going forward with the new IND? It does NOT say they need approval?

    Sentiment: Buy

  • I can't paste full article, but try google

    Telomerase stimulates ribosomal DNA transcription under hyperproliferative conditions
    Nature Communications
    5,
    Article number:
    4599
    doi:10.1038/ncomms5599

    Received
    19 August 2013
    Accepted
    07 July 2014
    Published
    13 August 2014

    Abstract

    Abstract•
    References•
    Author information•
    Supplementary information

    In addition to performing its canonical function, ​Telomerase Reverse Transcriptase (​TERT) has been shown to participate in cellular processes independent of telomerase activity. Furthermore, although ​TERT mainly localizes to Cajal bodies, it is also present within the nucleolus. Because the nucleolus is the site of rDNA transcription, we investigated the possible role of telomerase in regulating RNA polymerase I (Pol I). Here we show that ​TERT binds to rDNA and stimulates transcription by Pol I during liver regeneration and Ras-induced hyperproliferation. Moreover, the inhibition of telomerase activity by ​TERT- or ​TERC-specific RNA interference, the overexpression of dominant-negative-​TERT, and the application of the telomerase inhibitor imetelstat reduce Pol I transcription and the growth of tumour cells. In vitro, telomerase can stimulate the formation of the transcription initiation complex. Our results demonstrate how non-canonical features of telomerase may direct Pol I transcription in oncogenic and regenerative hyperproliferation.

    Sentiment: Buy

  • ryanvball1 ryanvball1 Aug 18, 2014 7:41 PM Flag

    Great find indeed. I'm repeating this as it stood out...

    "Following 90 days, none of the mice injected with Imetelstat-pretreated cells showed any clinical evidence of tumor formation, while all of the mice injected with untreated E520 cells required killing."

    Sentiment: Buy

  • Reply to

    Take a breath

    by ryanvball1 Aug 13, 2014 8:41 AM
    ryanvball1 ryanvball1 Aug 16, 2014 10:02 PM Flag

    Bump

    Sentiment: Buy

  • "I'm short at 1.81 and not covering until we are under a buck."
    DR- you are so sad and have lost so much.

    Sentiment: Buy

  • Reply to

    Take a breath

    by ryanvball1 Aug 13, 2014 8:41 AM
    ryanvball1 ryanvball1 Aug 15, 2014 8:54 AM Flag

    Should probably bump mine as well

    Sentiment: Buy

  • Reply to

    Some context.

    by sdrawkcabeman Aug 14, 2014 6:45 PM
    ryanvball1 ryanvball1 Aug 15, 2014 8:53 AM Flag

    nice
    bump

    Sentiment: Buy

  • Reply to

    Take a breath

    by ryanvball1 Aug 13, 2014 8:41 AM
    ryanvball1 ryanvball1 Aug 13, 2014 7:39 PM Flag

    ty

    Sentiment: Buy

  • ryanvball1 by ryanvball1 Aug 13, 2014 8:41 AM Flag

    We have known since March that the timeline for the PH2 trial was pushed back 6 months from July to first Q of 2015. That didn't change. Chip could have pushed it back, but did not. That really is not the end of the world.

    There was always the primary request of the FDA to track LFTs to baseline, and Scarlet said "what takes a long time to happen takes a long time to unhappen". Geron needs to track down patients, get their IRB approval, get patient approval to take new blood samples, and then track the results- possibly for months.
    This hasn't changed. There has not been bad news regarding LFTs- quite the opposite, MC was released and it is fair to assume the LFTs were not an issue. This will continue.

    Geron is getting the Mayo IND at the end of September, however and even more important, they already have (or are almost complete) all the DATA from Mayo, and that is VERY significant. They are using that data "to inform the the new Phase 2 trial" which means they are certainly moving forward and the data from MC will help inform them on dosages, mylosuppressive effects etc. This is very good news.

    The 33 patients still enrolled in the Mayo all have CI or PR or CR. That seems remarkable and also not fully appreciated. We don't know exactly the status of the MDS patients, but we do know that every single one is still enrolled more than 8 months later. I find this significant and almost astonishing.

    Other than a few investors that inexplicably hoped for a hold release, nothing new or bad occurred on the call, quite the opposite. Time line still in tact. Data being transferred. Tefferi on-board. Patients in remission- MANY patients. Maybe a filing with the FDA after the transfer at end of Sept? Followed by release in Oct? Followed by by abstracts in November? Followed by ASH in December? Followed by upgrades in DEC?JAN? Followed by MDS studies in FEB? ETC ETC...

    Take a breath. Let unknowledgeable traders abandon ship and long term investors make multiples of $$$

    Sentiment: Strong Buy

  • Reply to

    Dr. Tefferi's Quote

    by beavertail_splash Aug 9, 2014 7:25 AM
    ryanvball1 ryanvball1 Aug 9, 2014 9:36 AM Flag

    Source please?

    Sentiment: Buy

  • Reply to

    Phase II

    by blackmarango Aug 5, 2014 3:11 PM
    ryanvball1 ryanvball1 Aug 6, 2014 11:16 AM Flag

    Irish and Beaver,
    I do not know if I read your post correctly but according to the 8K...
    "In connection with entering into the Transfer Agreement, Mayo Clinic has
    transferred data from the clinical database (the “Transferred Information”) for the Myelofibrosis IST to Geron."
    The data transfer is DONE - "HAS TRANSFERRED". Geron is using the data to inform (plan) their new Phase 2 study.

    The only transfer on Sept 30 is the official IND, the paperwork, the official hand-over and the responsibilities that go with it.

    IMO, that is what the market is "missing". This is important for investors to understand.
    Ry

    Sentiment: Strong Buy

  • Reply to

    Phase II

    by blackmarango Aug 5, 2014 3:11 PM
    ryanvball1 ryanvball1 Aug 6, 2014 10:32 AM Flag

    End another few points (if they were not made before),
    You say "They still need FDA clearance to do that"
    Simply Not true, it is a separate IND and no holds at all, no clearance needed.

    You say "I think the deal with the MC requires GERN to wait for the data and to start until after Tefferi completes his ASH reports"
    Simply wrong, the Data has already been given to Geron as per the recent filing
    Also, Why would the MC require Geron to wait? This comment from you makes zero sense
    Geron will of course respect the embargo re data, but will move asap, both MC and Geron would obviously want that.

    Again "I think the deal with the MC requires GERN to wait for the data and to start until after Tefferi completes his ASH reports and I don't expect that GERN will be allowed to disclose effect results until sometime in October after the MC has reported them"
    NO no no
    Geron will not report anything in October, they will wait until after Tefferi has presented at ASH in December.

    End I do appreciate your comments here, but many people follow you, so I want to be crystal clear and make sure we have "fact checks"

    I have had long conversations with another Long here and we both were initially puzzled and deflated by the news, However, after discussing and thinking, we see the light and realize this is very good news and feel the market will understand it much better(as it took us time too) after the Conf Call

    Sentiment: Buy

GERN
2.340.00(0.00%)Sep 17 4:00 PMEDT

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