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Geron Corporation (GERN) Message Board

ryanvball1 22 posts  |  Last Activity: Apr 16, 2015 9:24 AM Member since: Nov 6, 2013
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  • Reply to

    Springtime for Imetelstat

    by irishtrader52 Apr 15, 2015 9:25 AM
    ryanvball1 ryanvball1 Apr 16, 2015 9:24 AM Flag

    Irish Trader, When does John start up again? Will the patients in the long lasting pilot study start infusing before the Phase 2 studies start or at the same time? Traveling to Minnesota can't be easy and one would think Jansen would try to be very helpful to the patients who have responded. How are they treating you and John?
    TY, Ry

    Sentiment: Buy

  • ryanvball1 by ryanvball1 Apr 15, 2015 9:09 AM Flag

    The CEO did a very fine job as he showed some excitement because he knows that not only does Imetelstat work, but this drug is going to be tested is every Heme, and then other cancers. He knows he has something special. SDRAW had a nice summary and I will be buying more because trials are going to be very robust, and with transfer done, it is full speed ahead.

    Sentiment: Buy

  • ryanvball1 ryanvball1 Apr 14, 2015 9:07 AM Flag

    P- still think 10$???

    Sentiment: Buy

  • Reply to

    A Fish Story

    by irishtrader52 Apr 7, 2015 5:24 PM
    ryanvball1 ryanvball1 Apr 8, 2015 9:49 AM Flag

    Nice fishtail... 13 down thumbs??? Wow, the shorts are in here and scared to DEATH. While I don't completely understand this new way to fish, I just might try it. I get the feeling that not only is Chip being quiet, but so too are Dr. Tefferi and Jansen- and hopefully they will have a big fish story soon...

    Sentiment: Buy

  • Reply to

    Anyone know when Dr T speaks again?

    by biotech4lifeusr Mar 31, 2015 1:17 PM
    ryanvball1 ryanvball1 Apr 2, 2015 9:27 AM Flag

    Thank you Mrs. Irish, or is it Mrs. Trader? If we look at the previously transferred IND from MC, that took about 3-5 months, so this time would be similar, meaning about now! I estimate June. I am hoping for news flow following transfer.

    Are you allowed to share when John will start up again or is that confidential?

    Sentiment: Buy

  • Reply to

    Anyone know when Dr T speaks again?

    by biotech4lifeusr Mar 31, 2015 1:17 PM
    ryanvball1 ryanvball1 Apr 1, 2015 9:33 AM Flag

    Good Morning Irish,
    The Imetelstat IND NCT01731951, finishes in September. Is that when the transfer takes place?
    Enrollment: 80
    Study Start Date: October 2012
    Estimated Study Completion Date: December 2017
    Estimated Primary Completion Date: September 2015 (Final data collection date for primary outcome measure)

    I believe that is when the transfer will take place, however, Pten thinks the trial will be completed sooner so the data will be complete and ready to process in order to be presented at ASH 2015.

    Sentiment: Buy

  • ryanvball1 ryanvball1 Mar 30, 2015 7:47 PM Flag

    Thanks P, One thing I found to be very important is that 23 patients were still being treated at the end of September and also 23 patients at the end of December. It sounds like there might be 20-21 now or Scarlet might be confusing those on study with those on study but not getting infusions. Not losing a single patient from Sept to Dec? Sounds great.

  • ryanvball1 ryanvball1 Mar 30, 2015 9:38 AM Flag

    Irish, I think you are right that the common biomarker might be telomere length, or maybe telomere activity? You have said John will start infusing near home when next study is up and so will others in his study. I was wondering what will happen to the other patients from the original 80? Some are still in the trial but aren't part of your husbands group (or cohort?). Some of those are MDS patients and an AML patient, along with many other MF patients, so what will happen to those? Is that a separate trial coming or are they all grouped together? Any idea how many patients are still infusing?
    Thank you, Ry

    Sentiment: Buy

  • ryanvball1 ryanvball1 Mar 27, 2015 9:21 AM Flag

    Ear, isn't that the beauty (and ironic difficulty) that Imetelstat seems to be the one drug that works on multiple mutations? Pten said that JNJ and Tefferi were having a hard time finding biomarkers because the drug was having an effect on multiple targets and maybe every target. He thinks that the MF trial will be open to MF patients with every mutation, and eventually MDS will also have a wide open door. I'm not sure I agree, thinking JNJ will want specific targets with specific gene mutations or other markers.

    It might be that multiple drugs will be formed to target these genes in specific fashion, while Imetelstat could be used on all of them. I think JNJ will soon have multiple combo studies going by 2016 and certainly 2017 where Imetelstat is used in combo with these and other drugs

    Sentiment: Buy

  • ryanvball1 ryanvball1 Mar 23, 2015 9:31 AM Flag

    Bump... This is important Geron news. MDS is serious and no drugs are capable to handle the disease. Dr.. Tefferi, Do your MDS presentation NOW!

    Sentiment: Buy

  • Should be a boost for Geron today. This simply shows that what Imetelstat does is ground breaking...

    Sentiment: Buy

  • ryanvball1 ryanvball1 Mar 20, 2015 8:34 AM Flag

    MPN forum is run by and sponsored by Incyte. Of course they will try to protect their investment by knocking Doctor Tefferi when he criticizes their drug for lacking any efficacy . Dr. Tefferi has no interest in any company, he treats patients using a plethora of drugs, always looking for a cure- always trying to treat and affect the disease. I deeply respect any man who is fearless and speaks what he thinks is the truth, even when he know he will be attacked by a monster sized lobby. When MPN Forum has an author write an article telling Tefferi to stop voicing his opinion, it must end with the following.... "This author was paid $25,000 cash by Incyte. This website and forum are sponsored by Incyte" That's the truth and the science will one day win out as Imetelstat (or some other drug) will take the place of Jakafi

    Sentiment: Buy

  • Reply to

    pre market activity by shorts

    by ryanvball1 Mar 12, 2015 9:06 AM
    ryanvball1 ryanvball1 Mar 13, 2015 8:51 AM Flag

    Same as yesterday. Remember they drove price down, pre- open was close to $4, then a 10% run up to 4.40? Same again today. Short funds drive price lower, hope that small guys sell out. Then, the HFs cover all day long at better prices. Buy the dip if we get one. $5 coming next week.

    Sentiment: Strong Buy

  • ryanvball1 ryanvball1 Mar 13, 2015 7:39 AM Flag

    I spoke with Phil yesterday and he sounded even more bullish after reading the 10K. Here is his post- think he called this one perfectly, and he has made his buddy a ton of money! P- round at PB on me next week? Owe you.

    Sentiment: Buy

  • Reply to

    10-K 900Million PLUS Royalties - wow

    by hbsurfcitycal Mar 11, 2015 10:20 PM
    ryanvball1 ryanvball1 Mar 12, 2015 9:08 AM Flag

    Irish, When will John start Imetelstat treatment? Will it be at Mayo or closer to home?
    thanks, Ry

    Sentiment: Buy

  • Been some serious short covering lately. Pre-market selling is from large short hedge funds trying to drive price lower on thin volume. They then scare small retail into selling as these hedge funds buy and cover all-day long at lower prices.
    Don't fall for it.

    Sentiment: Buy

  • Reply to

    10-K 900Million PLUS Royalties - wow

    by hbsurfcitycal Mar 11, 2015 10:20 PM
    ryanvball1 ryanvball1 Mar 12, 2015 7:42 AM Flag

    You copied this from my buddy. Great post, but give him the credit...

    Sentiment: Buy

  • I was actually impressed with the presentation.
    -Talked about Disease Modification in MF AND ET- don't think he had previously emphasized DM in ET.
    -No pushback in timeline
    -Emphasized ALL their patients in IST had Life Expectancy of LESS than 3 years. When you do the math and realize we are 18-24 months in, looks like just 2 deaths? A couple relapses but majority had CR/PR or at least Stable Disease. I'm bummed the SD patients left study, but certainly we will soon (in 12 months) see LE has been exceeded for a substantial number of these MF patients. That data should move drug much closer to approval.
    -Scarlet emphasized a BIG difference between CR/PR and the minor CI. He is starting to emphasize that Imetelstat not only matches Jakafi in Spleen response ALONE- but adds the huge benefit of remissions and other improvements. He is basically stating Imet is CLEARLY better than Jakafi
    - Talked about first time ever seen bone marrow clearing in this disease and said we have "Numerous" other patients where this has occurred.
    - contrary to what Jsan has said in here, Scarlet clarified that NO other drug in either trials or on market (Jakafi) has had these responses. That clears that up once and for all.
    - Said "we think drug is potentially going to be useful in MF MDS and AML". He KNOWS MDS data is good. He could NEVER say this unless he knew MDS results were good- i think we will get a remission or two in MDS.

    I took the presentation as very positive. I heard for the second time that he is saying "we have the best drug". He also was confident this drug is going to work in ET, PV, MF, MDS and AML. To what extent? I don't know, it works in a high number of patients and even those that don't get full remission get SD. Of note, recall ALL the ET patients had responses and NONE of the mice with AML relapsed- not one. I also recall Dr. Lane stated at his ASH presentation that in addition, not mouse had relapsed to date- so that could be another 50 or 100 days- stunning

    Sentiment: Buy

  • Reply to

    Why I think Geron will fail

    by zarabesque Feb 10, 2015 5:15 AM
    ryanvball1 ryanvball1 Feb 10, 2015 9:09 AM Flag

    I am going to say it again. There are NOT emerging companies with superior technology. NONE. Listen to Scarlet. No drug, none, not approved or in trial, has PRs or CRs. NONE. No competitors. No competing drugs. No others cause remission.
    Please do NOT call a lie "valid". Either post a trial that gets 20% remissions (or ANY for that matter) or post accurate info.

    Sentiment: Buy

  • Reply to

    Why I think Geron will fail

    by zarabesque Feb 10, 2015 5:15 AM
    ryanvball1 ryanvball1 Feb 10, 2015 9:02 AM Flag

    Sorry, but this is completely false. Scarlet even talked about it just yesterday. He said no current drug (there is only 1 approved for MF) and no drug in any trial has demonstrated CRs or PRs. THAT IS THE FACT There are no other options. There are NO comparisons to Imet. If you think there are? Then post the facts and the trials. I am posting what Dr. Scarlet said, if you think otherwise then post results of a trial, ANY trial where there were CRs and PRs in MF.
    This is THE drug. Yes it is taking time, but here are no competitors.

    Sentiment: Buy

GERN
4.30-0.03(-0.69%)Apr 24 4:00 PMEDT