That the overall market sentiment towards biotechs and the WF downgrade are responsible for the PPS action today. And yes, report / news could be a significant catalyst but looking back at how the stock has reacted published good news in the past doesn't give me too much hope at this point. I am getting killed on some small positions in ziop calls. I have no one but myself to blame this is the price you pay when you over speculate. Things will get better at some point.