Sun, Jan 25, 2015, 7:10 PM EST - U.S. Markets closed


% | $
Quotes you view appear here for quick access.

Sarepta Therapeutics, Inc. Message Board

simp08801 211 posts  |  Last Activity: 9 hours ago Member since: Apr 10, 2000
SortNewest  |  Oldest  |  Highest Rated Expand all messages
  • Reply to

    AF skewer job on Garabedian ...

    by simp08801 Dec 22, 2014 4:30 PM
    simp08801 simp08801 Dec 22, 2014 8:45 PM Flag


    I do not know if its true

    but there was a suggestion that all 6 boys in the RNA x43 trial have dropped out

    but further, enough time has passed that if this was literally true, it would leak out further

    and it has not

    and those suggestions of this came from somebody the srpt followers generally assume speaks gospel

    my current view is that nobody speaks gospel here

    almost everything you hear is to some degree, either overstated or understated to fit the bent

  • Reply to

    AF skewer job on Garabedian ...

    by simp08801 Dec 22, 2014 4:30 PM
    simp08801 simp08801 Dec 22, 2014 8:40 PM Flag


    The BioMarin purchase of RNA suggests that the RNA toxicity issues have been to some degree, overstated in the Srpt mass media circles

    We must assume that BioMarin particularly diligenced this issue and determined that the RNA safety issues did not rise to the point of overcoming the potential clinical value of Drisa to dmd x 51 patients

    frankly, I find it impossible to reasonably assume otherwise

  • Reply to

    WOW AF skewered Srpt CEO

    by simp08801 Dec 22, 2014 4:26 PM
    simp08801 simp08801 Dec 22, 2014 4:42 PM Flag

    I disagree

    I think the "only to find out later" language was specifically written to imply that he was hood winking the community and investors

    I am not saying I agree with such assessment, but I take that phrase to clearly insinuate it

    I believe those exact words were by design


  • Here is exactly what AF said when nominating RNA CEO:

    Hans Schikan, Prosensa

    Let's compare two chief executives, both running companies developing new drugs to treat Duchenne muscular dystrophy, a rare, muscle-wasting disease. One CEO is gregarious in public, eager to court the support of patients and their families. He's a bit promotional and prone to making big promises. If he angers or offends anyone, it's only because he's working so hard to cross the finish line.

    The other CEO is quiet, reserved. He cares just as deeply about patients and their families, but is also worried about making promises he can't deliver. He'd rather work behind the scenes to advance his company's goals instead of negotiating in public. Politeness is a virtue.

    Who's been more effective in developing a new DMD drug so far? The first CEO's gabby nature and penchant for promise-making appears to give him the edge. Only later do we find out the CEO's feel-good story is a facade covering up fractious corporate infighting, poor decision-making and alienation of regulatory authorities. Patients and investors are punished.

    Meanwhile, the second CEO deals diligently with setbacks, working to extricate his company from a foundering Big Pharma partnership in a position to still achieve its goals. He listens to regulatory authorities and quietly builds a case to support his drug's approval. There's nothing flashy about his approach, but it's effective. When the first CEO blows up and his drug is delayed, the second CEO is still standing. His company will be the first to submit for regulatory approval of a DMD drug.

    And in the second CEO's "spare" time, he sells his company for $840 million, rewarding shareholders for their patience and bringing in a more experienced partner to increase the odds his drug is approved.

    Congratulations, Prosensa's Hans Schikan. Your nomination for Best Biotech CEO of 2014 is well-deserved.


  • has anyone read the 12/12/14 AF article on his 2014 Biotech CEO of the year nominations?

    I knew he kinda pulled back on srpt, BUT HOLY COW!

    he completely skewered Garabedian, and was one step away from calling him a complete fraud!

    quadruple WOW

    AF clearly insinuated with thin veil, that the Srpt CEO duped dmd community and investors

  • this backwards price targeting is a mullet dream come true

  • "I think you're a jackhole but more important to this discussion, you're a horrible clinician"

    I was reading holiday cards in Hallmark and I came across this

    Happy Holidays to each and every jackhole on this thread!

  • simp08801 simp08801 Dec 20, 2014 4:08 PM Flag


    you are stating the obvious

    the FDA has been less than thrilled with the N=12 no matter what lipstick is used

    the conversion to a MITT n=10 just made it worse with the FDA

    there is lotsa noise from both sides, but of the few things that seem clear, the n=12 was always a problem no what was said by either side to suggest otherwise

    2015 should tell the tale, one way or another

    the company's repeated delays and not living to the exact letter of the prior FDA guidance was the perfect set up for the 2014 wash out

    frankly, the company'd delays literally washed away much of the confusion caused by the FDA, and once the FDA figured this out, it went on the offensive this fall

    as they say, the best defense is a good offense

    even in the regulatory process

    the company literally handed the FDA the ball when it tried to change all its own timelines but somehow the FDA was supposed to stick to its timelines

    the FDA got smart and took the ball and ran with it

    now its all on the company, and the FDA is just patiently waiting for the company to actually finally honor its promises to the FDA

  • simp08801 simp08801 Dec 19, 2014 9:31 AM Flag


    by the time we would know if the drug is a bust, the company will have burned another $75 to $100 million

    worse yet, I have been in two investments that traded below cash value on failed technology

    13 could become 6 on failed 166 and data reread bust

    unfortunately, I wish I saw it otherwise

    I am not expecting, but I believe the wrong data could result in it

  • 3.48

    wait, we made it already!

    I knew I was right

    my allocation such price is as follows

    1. maptuit: .0001

    2. dr. first .0001

    3. escrip: .0000000000000000000001

    4. DLPeepee: .00000000001

    5. BYOB (or is it D?): .0000000001

    email: all the rest

    did I miss anything?

  • It was IMO highly unlikely there would be any news this week, but it was not impossible

    but after today, we surely graduate into impossible from now to year end

    the stock found its balance in the 13s

    if you are a long term investor, 2015 may finally be the year where you will find out if srpt will make it, or not

    personally, I think it makes it with a very very bumpy road, where things could get even worse before they get better

    168 wk data and dyst reread are so key

    if they are at least decent, even the fda will eventually settle on a path

    if they aint good, look out way way way way way below


  • Reply to

    where is devil?

    by simp08801 Dec 18, 2014 8:28 AM
    simp08801 simp08801 Dec 18, 2014 12:38 PM Flag


    do not forsake me

    I could be your only true friend here

    I consider you my only true friend, since star threw me under the bus

    piney does not count, cuz she is more than a friend

    I was friends with johnny87778 until his dog bit me

  • simp08801 by simp08801 Dec 18, 2014 8:28 AM Flag

    why does he always disappear when certain others do?

    devil, I am here to help you overcome your demons

  • Reply to

    From christine today, "Please tell the board

    by thigrlsrk Dec 16, 2014 4:19 PM
    simp08801 simp08801 Dec 17, 2014 8:04 AM Flag

    assuming this is literally accurate, this is spectacular news for the entire dmd community, and also for long-term srpt investors

    but for now, I am certain that a large percentage of the srpt stock sellers actually already believe this to be true

    but they also believe the company will NOT be issuing any scientific evidence to validate this believe any time soon, especially not be 12/31/14

    again, the stock is detached from the company for now

    fully detached

    its a year-end book marking vehicle for large institutional investors, long and short, and the clear bent is long exit and short topping off into book marking

    I am certain the srpt long institutional base has taken a gigantic whack

    the BioMarin/RNA deal has proven to be a quadruple negative in perception, for now

  • Reply to

    For 3 years he sat on his

    by starfe11 Dec 17, 2014 7:17 AM
    simp08801 simp08801 Dec 17, 2014 7:54 AM Flag

    the issues may be bigger and deeper

    the company had board members who were willing to make open stock market purchases in the $30s

    Now, there has not been a single insider buy, even all the way down to the $12s

    What is the difference now vs. then?

    IMO, its all about confidence in BOD members regarding the issue of whether the CEO is properly reading the FDA signals

    previously, I suspect the BOD members assumed what they heard back from the CEO on the FDA vibe was essentially accurate

    Now, I suspect they wonder whether he is capable of accurately reading the FDA signals he is receiving

    supporting a CEO as a BOD member should never be confused with spending your own money on the stock


    regarding BOD wallets, I believe the CEO has lost the confidence of BOD members

    this does not mean the FDA process will not ultimately result in some sort of drug approval

    but I do think it means that pre FDA approval, the BOD members are no longer blind believers of what the CEO says when they decide to invest their own money in srpt stock

  • Reply to

    From christine today, "Please tell the board

    by thigrlsrk Dec 16, 2014 4:19 PM
    simp08801 simp08801 Dec 16, 2014 4:50 PM Flag


    none this matters as to stock trading from now til 12/31

    the trading is DETACHED from the company

    it will matter max mucho and a ton, when reality returns after 12/31

    the stock is "trading vehicle mode" and what the company does is 100% irrelevant to the trading right now

    take the stock price and subtract the cash

    ask yourself if intelligent investors are trading in the "company"

    they are not

    the trading is in the stock vehicle, ONLY, from now til 12/31

    institutional shorts can prepare to mark their year end books with 100% comfort of zero surprises

  • simp08801 simp08801 Dec 16, 2014 2:32 PM Flag


    you just perfectly defined every biotech start up investment I have ever been in

    you should start your own dictionary!

  • Reply to

    Longs very quiet today.

    by devilsyankeesfan Dec 15, 2014 3:02 PM
    simp08801 simp08801 Dec 15, 2014 3:24 PM Flag

    dear devil

    I cannot make any noise because I am chewing on a piece of leather

    which chewing I expect to be doing from now til the close on 12/31/14

    I am available to communicate via morris code, or carrier pigeon

  • simp08801 simp08801 Dec 15, 2014 11:46 AM Flag


    tax loss selling can occur until the last trade of 2014

    but obviously we can speculate on this with more specificity

    Srpt will be a presenter at the annual JPM health conference in mid January

    some srpt longs (with tax loss sell needs) may think that if srpt has anything material to disclose in January, that it will target that event

    thus, they can take the date of the srpt presentation at JMP, and then count back 30 days

    thus, they could sell up til that date, and then buy back before the conference

    its just a theory, one of many

    the "friday" I was referring to was this friday

    all speculation in absence of facts

  • simp08801 simp08801 Dec 15, 2014 10:24 AM Flag

    dear devil

    congratulations on your "13s" call

    and yes, us longs, are IMO in a mega "no win" situation for the remainder of 2014

    what happens in 2015 will be most interesting, either way

    but for 2014, IMO, the current srpt institutional shorts can feel very very comfortable that they will be marking their srpt short at year-end with zero risk of surprise

    tax loss selling can run right to Friday

    some srpt longs will count the days til the JPM event in mid January, and they will tax loss sell srpt until they hit the 30 day limit

    personally, I think it an entirely reasonable assumption that if srpt has any material news available for release in January, that it will time it to be at or near the annual JPM event

    IMO, once we clear Friday, the shorts are home free til the JPM event, at the soonest

    and one request

    given your track record, pleez do not predict any more 2014 price drops, as they all seem to come true!

12.18-0.05(-0.37%)Jan 23 3:59 PMEST

Trending Tickers

Trending Tickers features significant U.S. stocks showing the most dramatic increase in user interest in Yahoo Finance in the previous hour over historic norms. The list is limited to those equities which trade at least 100,000 shares on an average day and have a market cap of more than $300 million.