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Sarepta Therapeutics, Inc. Message Board

simp08801 284 posts  |  Last Activity: 15 hours ago Member since: Apr 10, 2000
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  • Reply to

    hi its dr death

    by simp08801 Jul 1, 2014 8:32 PM
    simp08801 simp08801 Jul 2, 2014 8:15 AM Flag

    jrrt

    you have focused on the exact 120 week trial data points that have been focused on by certain investors as a precursor to establishing realistic expectations on the 144 week data

    I have been surprised to see so many smart posters say there were no negative signals in the 120 week data

    there were 3 of them

    you have cited 2 of them

    IMO, based on the totality of the 120 wk data, to assume anything but a decline in the 144 wk data is not reasonable

    this does not mean the drug is not approvable

    it means that in the finance market world, the data will be more prone to sinister interpretation targeted at lemming longs who live in the "drug restores muscle/all boys improving" world

    excuse me but I have to go now because I trade the stock all day every day, or so says gri

  • Reply to

    hi its dr death

    by simp08801 Jul 1, 2014 8:32 PM
    simp08801 simp08801 Jul 2, 2014 7:59 AM Flag

    gri

    LOOK AT THE RECENT NON VOLUME

    LOOK AT THE RECENT MILD PRESSURED TRADING

    LOOK AT A PRICE THAT 22% BELOW THE RECENT SECONDARY FINANCING

    do you actually think if there was a single solitary positive leak on the 144 week data that the recent trading pattern would be occurring?

    hint: NO

    in fact, there have been persistent quiet whispers to the contrary

    now, if those whispers were widespread and generally believed, the stock would have further deteriorated on much higher volume

    instead, they are believed just enough to curb the momo and make larger holders who hear these things nervous

    I hope the data is spectacular in all ways for all concerned, from every angle

    but something feels different this time around

    the n is just too small and there are just too many variables for simple results to appear every time with each passing 24 weeks

    word is that the FDA actually understands this

    IMO, the drug is FDA approvable by late 2015 as long as there are no data implosions

    but also IMO, the bar on the data needs to be lowered at this stage of the process

  • simp08801 by simp08801 Jul 1, 2014 8:32 PM Flag

    I believe aggregate 144 week data will be more complicated than previous data

    the ellsworth boy videos are impressive, and if there are a few remaining boys who are "improving", he could be one of them

    but IMO, extrapolating the ellsworth boy into all other trial participants is a prescription for disappointment

    now is the time of set aside all rosy expectations

    wait for the actual data, and read same, not against unrealistic rosy expectations, but against the reality of the disease and the realistic function of the drug

    spend less time being disappointed that you did not hear what you decided was happening, and more time looking at what actually is happening

    IMO, the drug is still approved in later 2015, as long as results to do not fall off a cliff

  • Reply to

    FWIW Jim Baker

    by thigrlsrk Jun 30, 2014 6:27 PM
    simp08801 simp08801 Jul 1, 2014 8:05 AM Flag

    it is an open issue regarding whether there will ever even be a 4th biopsy

    check with zoooey on the details of this

    ...

  • let the record show that I MADE IT UP

    I did so in reliance on a bio rhythum report from copp and an anecdotal evidence report from zooooey

    thus, I stand by it, til death

  • Reply to

    Have to wonder

    by thigrlsrk Jun 29, 2014 11:22 PM
    simp08801 simp08801 Jun 30, 2014 8:26 AM Flag

    dear devilsfan

    thank you for that orderly and cogent posting

    but may I offer some friendly advice? ...

    its just not the same when you omit the "big three":

    TURD (my personal favorite)

    AWFUL

    TERRIBLE

  • they each got PPMD grants

    Pat Furlong: "We also announced that Sarepta Therapeutics will receive a $400,000 grant from PPMD to develop its morpholino exon-skipping technology to treat Duchenne (focused on duplications in Exon 2 and other rate mutations below Exon 6) and Prosensa will receive a $200,000 grant to fund the development of a multi exon-skipping strategy for Exons 10-30. "

  • simp08801 by simp08801 Jun 27, 2014 3:12 PM Flag

    "turd"

    "awful"

    "terrible"

    I challenge you to use these three words in one sentence, relating to any topic of your choice

  • I have a strong recommendation

    JEFF PAPPOWS

    its mostly about the people, and rarely about the project

  • Reply to

    I have something to say

    by simp08801 Jun 27, 2014 12:49 PM
    simp08801 simp08801 Jun 27, 2014 1:00 PM Flag

    thank you grey

    I took your advice and just ate 24 lithium batteries

    signed, zooooooey

  • hi this is simp

    I have something to say about srpt

    but I am just too emotionally delicate to say it after being beat down by the plethora of brutal and barbaric attacks upon my hapless soul by oh so many of you these past few days

    I dont care about my first amendment rights

    its the obliterated friendships with zooooey and tred that have me so devastated

    signed star

    Sentiment: Strong Sell

  • simp08801 simp08801 Jun 26, 2014 10:57 AM Flag

    I am stipulating that everything is wrong

  • Reply to

    Today does depict long term outcome here

    by simp08801 Jun 24, 2014 3:49 PM
    simp08801 simp08801 Jun 26, 2014 9:40 AM Flag

    wow copp

    your bio's are really on fire today

    I do have but just one request

    pleez stop referring to me and star as different people

    we are the same person

    although my official position is that my weiner is 1/72nd of an inch longer

    keep up your super sleuth on who and what I am

  • Reply to

    Today does depict long term outcome here

    by simp08801 Jun 24, 2014 3:49 PM
    simp08801 simp08801 Jun 25, 2014 11:36 PM Flag

    jim

    this just is not fair

    professional palm readers should be banned from message boards

    you cheated!

    I simply cannot believe how perfectly accurate your depiction of me is

  • Reply to

    thank god carrier pigeons are still not encrypted

    by simp08801 Jun 23, 2014 6:11 PM
    simp08801 simp08801 Jun 25, 2014 10:57 PM Flag

    yur still a mullet

    deal with it

  • Reply to

    Today does depict long term outcome here

    by simp08801 Jun 24, 2014 3:49 PM
    simp08801 simp08801 Jun 25, 2014 1:24 PM Flag

    more cluelessness by the clueless wunder

    IT IS NO NEWS

    not good

    not bad

    investors asked the CEO directly

    it was personal

    period

    end of discussion

    stop misleading people

  • Reply to

    The Company is on Sale

    by dystrophinanew Jun 25, 2014 1:58 AM
    simp08801 simp08801 Jun 25, 2014 10:20 AM Flag

    yo wggm

    I am very long the stock

    I assume there will be a few improvements (and no more than that), quite a few declines, but still better than natural history, and one significant decliner (as there was a few tests ago)

    drug is not a cure

    recent and increasing suggestions of wide scale improvements across board and muscle rebuilding are grossly misleading

    I continue to believe fda will approve the drug at some point later next year (as long as results do not get materially worse)

    but with each passing 24 weeks, I believe data gets more noisy (I was going to say complicated, but I am not sure if tred took his blood pressure medicine yet, so I am trying to be more careful)

  • if you want to read them, this is the info you need

    user Id: duncersaredooshers

    password: eternalmullet

    happy reading

  • Reply to

    The Company is on Sale

    by dystrophinanew Jun 25, 2014 1:58 AM
    simp08801 simp08801 Jun 25, 2014 9:36 AM Flag

    its not a 6 minute walk test

    earlier on in this trial, when there were repeated reports of max improving in every day life, which he sure appeared to be doing, the common assumption was that he was the outlier upside in the 6 mwt being taken at that time

    HE WAS NOT

    a common error is the mindless translation of anecdotal evidence into "guranteed" 6 mwt results

    its not linear

    and that IS the flaw with the test

    but the test is what is reported, not real life

    does anybody think the activists were screaming about 6 mwt to the fda?

    it was about real life, regardless of 6 mwt

    my statements have been ALL ABOUT the 6 mwt and the variability of it with a small n, as time goes by

    I am an optomist

    so I continue to hope that SOMEDAY, tred will actually turn his brain on and understand what I have been saying, and stop criticizing what I have not been saying

    as for zoooey, well, hope has to be eternal there

  • Reply to

    The Company is on Sale

    by dystrophinanew Jun 25, 2014 1:58 AM
    simp08801 simp08801 Jun 25, 2014 9:30 AM Flag

    I never said posts

    ever

    you have to talk to people

    I defy anybody to find a single solitary tweet, post or blog which sets forth how a boy did on a 6 min walk test

    find me just one

SRPT
20.58-0.05(-0.24%)Jul 25 4:00 PMEDT

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