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OneBeacon Insurance Group, Ltd. Message Board

snogreen 278 posts  |  Last Activity: 26 minutes ago Member since: Aug 30, 2000
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  • Reply to


    by bocamp1 Mar 11, 2015 5:11 PM
    snogreen snogreen Mar 12, 2015 7:07 AM Flag

    picking on anyone with the attitude of "my cost basis is better than yours" childish. What does it matter? What matters is if TB 4 ever works in a trial. Whether your own basis is 15 cents or $ will still make money. I think you should write Sigma Tau and tell them they are stupid too....because their "basis" is a lot higher than where we are now.

  • Hey Finkel, you should contact a fellow named Bill Maris at Google Ventures. It is the VC arm of Google. Google just pumped $425 million to him and his mission is to fine REGENERATIVE drugs & extend life. get it? "Regenerx"???? get it? he has $425 million to invest? get it? RGRX is 35 cents??

    here is the headline from Bloomberg. Copys and paste to (Google) of course and read the full article. GOOG wants to be BIG in regenerative therapies and drugs, and they have more money than God, but no drugs.:

    "Google Ventures and the Search for Immortality

    Bill Maris has $425 million to invest this year, and the freedom to invest it however he wants. He's looking for companies that will slow aging, reverse disease, and extend life."

  • Well, that spike brought back the shorty MM's. A number of MM's showed up yesterday to come and play. Wasn't just NITE. It's classic MM trader short big spikes on spec bios, and wait it down. The only thing DIFFERENT this time is that before, like last TWO years, RGRX was all but broke. So NITE was comfortable to short and press RGRX down, for the INEVITABLE tax puke & loss one point to 4 cents. NITE owned and controlled RGRX, for all intents. But TODAY..RGRX is not all but broke. It still has no money to speak of, but the three trials (China, Korea and USA( appear to be funded. So now it's a waiting game for trials start & results, and NOT a "going broke" short like NITE previously played. Going broke trade is now busted. Unless every single upcoming trail flops. So now RGRX will get a different kind of short, and probably a few more MM's playing. they play volatility. They play shorting the spike psychology...dumb money.chaing tiny, underfunded , speculative bniotechs...that have ages and ages to wait for news. So unlike other years with NITE shorting RGRX hard, and we hated them.......from here on we should THANK the new MM shorts, because they will provide the liquidity in case a large player wants to get on board for the gamble. Without the MM's willingly shorting 312,000.....a possible new player can't buy size.. So in a sense, large shorts is a GOOD we wait and wait for a trial start.

  • Reply to

    reading H. Ford patent

    by snogreen Mar 9, 2015 2:42 PM
    snogreen snogreen Mar 10, 2015 6:05 AM Flag

    What the heck? you (school) post:

    First, fact that you ask donk is nuts. Put him on ignore,

    Second, No you cannot make any inference the paten is approved. Wake up. The examiner was not GIVEN the appeal until feb 20. The examiner has been screwing with RGRX for OVER FOUR YEARS..FOUR YEARS. GET IT? So why on earth do you keep posting is is either GRANTED, or will be "any day". It is probably MONTHS away from his response.

    THIRD? The USPO changed things a couple years ago. The person FIRST TO FILE still has rights, even with a rejection. So even if RGRX get's "non final rejections" NO ONE can step over RGRX and file a better TB 4 dry eye. RGRX has it locked in place, a marker. So RGRX will just keep filing and appealing to wear USPO down. But at some point, it is critical they get it. Otherwwise it's scary to do a trial with no final IP issued.

  • Reply to

    reading H. Ford patent

    by snogreen Mar 9, 2015 2:42 PM
    snogreen snogreen Mar 9, 2015 2:51 PM Flag

    I am not 100% sure.....espanet is hard to figure. But HF applied this patent in July 2014, and it looks to me like the patent was granted Sept 10, 2014. But I'm not sure. EP means european patent. they give a "patent of invention" number.

    F 2014012532 W (Patent of invention)
    Event date : 2014/09/10
    Event code : 121
    CORRESP. PATENT D. : 14740921

  • I'm reading the new Henry ford patent appliction now. Long. Lot's on TB 4:

    "[0054] In our work, we evaluated whether thymosin beta 4 ("Τβ4") promotes differentiation of oligoprogenitor cells to oligodendrocytes in animal models of neurological injury. We discovered unexpectedly that Τβ4 increased expression of microRNA-146a and suppressed expression of proinflammatory cytokines of the Tolllike receptor ("TLR") signaling pathway, and that Τβ4 suppresses the TLR proinflammatory pathway by upregulating miR146a, with implication for the promotion of oligodendro genesis for clinical purposes.

    [0055] Tissue inflammation results from neurological injury and regulation of the inflammatory response is vital for neurological recovery. The innate immune response system which includes the Toll-like receptor ("TLR") proinflammatory signaling pathway regulates tissue injury. We evaluated whether that Τβ4 regulates the TLR proinflammatory signaling pathway. Since oligodendrogenesis plays an important role in neurological recovery, we employed an in vitro primary rat embryonic cell model of oligodendrocyte progenitor cells ("OPCs") and a mouse N20.1 OPC cell line to measure the effects of Τβ4 on the TLR pathway. In brief summary, we grew cells in the presence of Τβ4 ranging from 25 to 100 ng/ml of (RegeneRx Biopharmaceuticals Inc., Rockville, MD) for 4 days. Quantitative real-time ("Qrt:) PCR and Western blot data demonstrated that Τβ4 treatment increased expression of microRNA-146a (also "miR-146a"), a negative regulator of the TLR signaling pathway, in these two cell models. Western blot analysis showed that Τβ4 treatment suppressed expression of IL-1 receptor associated kinase 1 ("IRAKI") and TNF receptor-associated factor 6 ("TRAF6"), two proinflammatory cytokines of the TLR signaling pathway. Transfection of miR-146a into both primary rat embryonic OPCs and mouse N20.1 OPCs treated with Τβ4 demonstrated an amplification of myelin basic protein ("MBP") expression and differe

  • Hey, I just found another patent that has been filed ny Dr. Chopp and Henry Ford. In neuro & TB 4. But KEY is that it is only published so far in Europe. It was filed there in July 2014, and I am sure here too. but it is NOT published yet as filed, in US. RGRX got the neuro patent already. This one extends it with other compounds. See if Yahoo let's me past:

    WO2014113822 (A1) ― 2014-07-24


    Some embodiments comprise methods, systems, and compositions to promote, improve and/or increase neuronal differentiation, oligodendrocyte differentiation, or neurological outcome or function in a patient in need thereof. Some embodiments also comprise the administration a composition comprising a pharmaceutically effective amount of one or more of a group comprising microRNA-146a, a promoter of microRNA-146a expression, a microRNA-146a mimic, thymosin beta 4, and a phosphodiesterase 5 inhibitor to treat neurological conditions, disease, or injury in mammals, including in human beings."

  • Reply to

    Asian Buying

    by bocamp1 Mar 9, 2015 1:26 PM
    snogreen snogreen Mar 9, 2015 2:03 PM Flag

    Definitely buying, nice volume...not retail for the most part I bet.....but I don't think Asian. It's dead of night over there. I angle more towards a US based person/entity. Probably who has been aware of RGRX for a while, but didn't really step in. Have to say some positive things lined up....and the surprise was G Tree getting that money for free.....and then doing a convert financing. So now this RGRX lurker, sees that indeed..a Phase 3 just may be coming later this year....the FDA has already approved doing it....and it apperas that it can be funded by G Tree......and it appears that Ora Inc will do it.....which is the gold standard for CRO's.

    I've said befopre my day dream is Randal Kirk getting on board. he absolutely knows Thymosins. We know he knows TA-1..he made money on it a long time ago. He knows Goldstein basically invented I would think he knows Goldstein is now with TB 4. Just a day dream. Finkel is crazy not to send him packages of info.

  • Reply to

    another theory gone windy

    by thebasiles777 Mar 9, 2015 9:10 AM
    snogreen snogreen Mar 9, 2015 12:35 PM Flag

    God Bless ya' bull! You go for it! You deserve it...especially when you owned up the "ugh" that you have shares at $3.30! The low to mid $2 is my high. But not that many shares. I've whitteled my basis down to $0.55 here's to champagne when I get to breakeven $0.55...may take a bit. I have not added shares since 0.19 a while ago. I breech into six figures of shares already. I'm fine with that for now. But I have no problem buying more, even at far higher prices...on any trial "win".......because this board knows TB 4 inside and out, and on a trial win we can respond immediately knowing the worth of it. Other bio investors will clamor to get on..but they will take time to do DD and digest possibilities first. but we rally need a clear trial "win".....we haven't that so far. I'm focusing on some other plays lately (not bio), which are working fine.

  • Reply to

    another theory gone windy

    by thebasiles777 Mar 9, 2015 9:10 AM
    snogreen snogreen Mar 9, 2015 10:48 AM Flag

    God, you don't get it. It WAS a dump! Just as I thought they would. Selling a CONVETIBLE BOND is similar to diluting possible equity! That is why G Tree stock is down 15%! because the convert is seen as a dump.

    All in all, VERY good news. And while I expected G Tree to do an offering, the $7 million (plus) free grant as a total surprise. And like I said? if G Tree has gov't connections to get that kind of money, my bet is they have connections to the Korean drug approval agency too and it would NOT surprise me if the dry eye trial data review (when done) the approving agency... is NO where near as harsh as our FDA. wait and see.

  • Reply to

    another theory gone windy

    by thebasiles777 Mar 9, 2015 9:10 AM
    snogreen snogreen Mar 9, 2015 10:03 AM Flag

    I was not "windy" I was RIGHT! Certainly this is very nice and unexpected news that G Tree was about to get over $7 million in free grant money. well done! But I was still RIGHT, B7! Gtree stock was pumped up from 3,000 won to 5,500 won. I just knew they were doing it so they could do an offering....because RGRX stated that Gtree will need $25 to $30 million for USA trials. Low and behold, what happened? G tree pumped their stock almost DOUBLE, and at the high price they OFFER a convertible issue. A convertible issues offers POSSIBLE it is in the best interest of G Tree to get their share price up as much as possible.

    So I was not windy, I was right. Still? i have to say it is great news. G Tree obvioulsy has connections to gov't agencies to get such free money. If they are able to get such free money, it is not a stretch that they also have gov;'t contacts to the Korean drug approving administration??? Friends in high places??

    G tree stock is DOWN 15% today, B7.....just as I guessed....THEY PUMPED and then offering. i was spot on my prediction.

  • Reply to


    by drpiano5 Mar 6, 2015 11:49 AM
    snogreen snogreen Mar 6, 2015 3:13 PM Flag

    You better look at RGRX history. If RGRX is given the dry eye patent, BEFORE the end of May (warrants expire)...RGRX has to get over $0.55 to make them worth anything. So? Look at history.

    A. when RGRX received the US PAtent for the heart area, did RGRX zoom higher? No.

    B. When RGRX got the whole neurological patent in the US, did RGRX zoom up? No.

    RGRX shoudl go up on getting a dry eye, and eye related US Patent...yes...but I don't know if it is enough to propel RGRX from 0.25 to 0.60...where you'd make money. You need bigger news that the eye patent, IMO.

    the patent examiner only just received the appeal on FEB 20! It could EASILY take months for him to review and decide. PROOF IN THAT IS THAT the patent was FILED in 2011.....four years ago. You just aren't going to see the response that quickly. RGRX never has from USPO.

  • Want more evidence of the G Tre pump? 9which is a good thing for RGRX)........G Tree now has a market cap of about $91,000,000.....thanks to the share price rise (pump). However, RGRX now has a market cap around $25,500,000.

    SEE? G Tree is all but a biotech focused company now. ALL it has is TB 4 rights in a handful of Asian countries, and ONLy for eye related...and they also got USA eye rights for TB 4 in a JV with RGRX. But look at the figures. In essence, G Tree only owns "one leg" of the TB 4 cow....but the market cap of G Tree is almost 400% LARGER THAN RGRX!.....AND RGRX OWNS THE WHOLE COW!......G Tree market cap $91 million, RGRX $25 million.

    WHICh is a better buy? Which one is being pumped? I am amazed you all don't see. Any Koren with one half ounce of common sense would sell G Tree at $4.99 and BUy RGRX at $0.25 cents.....for every ONe share of G Tree you could buy 20 shares of RGRX!..........and RGRX has much or rest of world TB 4 rights in a deal, or all other indications besides Koreans w/ just eyes.

    If I was in Korea, the trade to make is SHORT G Tree (on the pump up) and BUY RGRX as a hedge. Short 1 G Tree buy 20 RGRX.....same outlay. even money. if TB 4 works you have 20 times the leverage in RGRX over 1 share G Tree. if TB 4 flops everywhere, you break even.

  • MAybe someday B7 will see. It's a GOOD thing that G Tree is pumping their stock. And they pump it in Korea. And I do not think Koreans are buying RGRX here. It's another one who did the spike volume here. To show you why the Koreans are being "pumped"........G Tree stock just traded 490,000 shares. It hit a high of 5,550 won. That is equivilant to about $4.99 US. SO? If 490,000 shares traded...and it is ballpark around $4.99 a share (at days high)...that gives a total trade value of $2,445,100.00.

    NOW? let's compare that to RGRX trade volumes. We do about 50,000 shares total. price is $0.025. Multiply 50,000 shares volume times 0.25 cents....and you get a trade total value of a grand total of $12,500.

    SEE B7????? G Tree is pumping and hyping their stock in trades almost $2.5 million a day. G Tree only has a small portion of TB 4. on teh other hand? the WHOLE COW of RGRX owning rest of TB 4..has a trade value today of $12,500. COMPARE.....$2,500,000 versus 12, tell me where the pump action is here!!!!. Koreans are CRAZY to pay $4.99 a share for G Tree now..........when the whole cow of RGRX is 25 cents a share. But God Bless the Korean PUMP! it's how G tree will probably get the $30 million they need for USA trials....PUMP it...but Korean investors blind. RGRX is a far more effective purchase. But don't look for G tree mgmt to admit that to them.......they need G Tree buyers..

  • snogreen by snogreen Mar 6, 2015 9:30 AM Flag

    My God, sometimes you are thick. you say:

    "Sno, when I suggested that there was interest and buying here from overseas you said no way and now you are predicting it.."

    Jeezus! I NEVER SAID THERE IS OVERSEAS BUYING. what I did say was that G Tree is pumping up it's stock over there, obviously. G Tree a coupekl months ago had a $35 million market cap. Uhh? How on earth could they, with a $35 million market cap, come up with $30 million for USA trials? HUH? the ansewr I said a month ago was that they woudl get G Tree stock UP. I posted that when GTree was 3100 won. it is now 5,500 won. I was right. Now waht I STATED was this. Gtree is pumping their stock over there, to get it up as high as can, so they do a secondary stock offering to get $$ for USA trials!Jujst MY prediction...i STATED that execs aren't taking it, but using for trials. I predict G Tree will sell stock. BUT! Any investor in G Tree, I said, woudl be FAR bettr off buying RGRX at 25 cents IN USA......G tree only has a small portion of TB 4. RGRX has almost ALL. But Korea is buying G Gtee, not RGRX. It is a GOO thing G tree is pumping! It is only way they will get $30 million! ...get it now?

  • G Tree stock in Korea is hitting highs, correct. A handful of weeks ago I posted that the stock to buy is G Tree. Fl_geezer liked the idea and he called his broker to see if he could buy. I just knew that G Tree would be pumping it. And they are. Geez was told that outsiders are not allowed to purchase stocks there. G tree was about 3,100 won then. today it is 5,550 won. this is great that they are pumping it up...because G tree does not have $25 to $30 million cash on hand to do the USA trials in late 2015 into 2016. Only way they get that much $$ is thru stock sales. Hence the pump, before the dump.......i.e....dump is the sale of stock to newcomers in G Tree.... after they pump it up. G Tree has not announce a sale, but I am predicting one. but it is a good pump for us in that the proceeds from a sale (dump) don't go to executives pockets, but rather into trials. Evidence that it is a "pump" is that any Korean is FULLY able to nuy stocks in USA. So if G Tree PUMPS their shares for TB 4, why buy G Tree? THE FAR BETTER BUY IS RGRX at 0.25 cents! Why pay up huge to buy G Gtree shares in Koprea, which control small bit of TB 4, when the WHOLE COW OF TB 4 & RGRX IS AT $0.25 cents/ See? Just watch the G Tree pump unfold.

    So cheer on the Korea 'pump", too bad we couldn't buy....I was very sure it would happen.

  • Reply to

    Warrants up 900%

    by bocamp1 Mar 5, 2015 12:30 PM
    snogreen snogreen Mar 5, 2015 2:22 PM Flag

    I hope they play out for you, geez and bull. It is an interesting move today. If it was just 1,000 or so warrants trade, no big deal. But around 12:30.........and in 15 minutes, they traded three times...20,000....10,000....4,333

    Thats a good sign. They expire sometime mid to late May.........around 55 cent exercise. Someone buying 34,000 of them is confident of something....and it better happen quick...about 75 days or so left.

  • Reply to

    wild day

    by snogreen Mar 3, 2015 4:21 PM
    snogreen snogreen Mar 4, 2015 4:59 PM Flag

    Similar patern thats been going on for weeks. Today was down again, but last 20 minutes it starts to go up..and strong into the bell......and almost always size on the close trade. About 1400 traded total yesterday, most of that on the close print. Similar today but much less volume. All indicates a smart trader trying to get as much as he can..print it down during day and take it up near bell and soak up whatever shares you can.

    NExt week, I think wedneday 11th.....JBS is giving year end and Q4 numbers. I expect them to be blowout numbers, mostly because of the collapse in Brazilian Real...but 84% of JBS revenues are in USA Dollars! The Real has dropped from about 2.20 earlier in year to a print today of 3.0. That is a massive move in about 10 months.and all going JBS way. If there ever is a deal in works for it SEB or someone else....time to announce woudl be next week. Fingers crossed and I hope it is SEB! Trade action points it just may be SEB.

  • Reply to

    ask taken out

    by thebasiles777 Mar 4, 2015 12:16 PM
    snogreen snogreen Mar 4, 2015 12:40 PM Flag

    shorts have backed off..agree. I don't think anything else is going to be "revealed" soon. The size done last couple weeks is great. But how do we know it was not NITE just buying to cover what they were short, in the face of the shareholder letter that was upbeat? NITE has pulled back shorting.....for now, it seems. OR? it could be a solid buyer wanting a good sized stake...but maybe he is in no rush and will do it over time...thus to get prices around this level..the news we NEED is a TRIAL STARTING....that will goose up some buy juices.....but i'm afraid, with what RGRX stated, a trial start is well off into later this year.

  • Reply to

    from the 8k joint venture

    by thebasiles777 Mar 3, 2015 6:16 PM
    snogreen snogreen Mar 4, 2015 6:32 AM Flag

    I wouldn't be too concernd with worry...."..the JV could end if " as a result of a challenge to a licensed patent,"..

    I think that is in there just as standard contract legalese boilerplate. Assume RGRX get's the dry eye patent, the chance of a challenge is slim to none. If you look at exactly what the UPSO examiner is doing .........he is leaving no crack, nook or cranny in his attempt to negate the TB4 dry eye patent issuance. RGRX lawyer fights back hard, as does Dr. Goldstein in filings. the KEY thing here is not IF there is ever a challenge to RGRX dry eye patent (after issued)....but IF RGRX can even GET the dry eye patent to begin with

    Don't read whatever donk says.. Full of junk posts. The apeal decision is not coming any time soon. the thuth is (he doesn't tell you) is that the USPO examiner in the TB 4 case did not even GET RGRX's appeal until Feb 20....even though RGRX lawyers filed it around Jan 6. It could be several months for his decision....but it is a very important patent. If Koreans own Dry Eye TB 4 rights now, I would be very hesitant to spend $25 to $30 million for USA trials in late 2015 or 2016, if you don't even have the PATENT to control TB4 in eye. Why bother.

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