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Prana Biotechnology Limited Message Board

soundsgood02 85 posts  |  Last Activity: Jul 30, 2015 1:19 PM Member since: Jul 26, 2002
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  • ...Illumina Ceo indicate recently that the way could be a combination of different tests...A partner for Tbio soon,like announced by Mr.Kinnon in the last CC?...
    Aug 20 TBIO presentation Katherine Richardson, Ph.D., Vice President, Research & Development, Transgenomic, Inc.

    The use of “liquid biopsies”, where limited or no tumor tissue is available, is increasingly important for molecular demographics, diagnostics and pharmacodynamic monitoring of patients during therapy. The combination of MX-ICP with many different downstream analysis platforms means that efficient detection of alterations at ≤0.01% in samples is feasible for most laboratories. Increased sensitivity using less DNA enables monitoring and detection of alterations in the low volumes of liquid biopsies for patient treatment, monitoring and surveillance.

  • From the PR
    "“An entire day at this conference is dedicated to liquid biopsy, which is indicative of the level of interest it is generating among researchers, clinicians and the biopharma industry.”

  • Reply to

    From research to diagnostic....

    by soundsgood02 Jul 15, 2015 3:00 PM
    soundsgood02 soundsgood02 Jul 28, 2015 5:50 PM Flag

    Liquid biopsy is a future standard of care...Nothing about mutation detecton from Fmi new trial...

    Foundation Medicine, Inc. (FMI) today announced the initiation of a large-scale, multi-center prospective clinical study to validate its circulating tumor DNA (ctDNA) assay for multiple, solid and hematologic tumor types. Expected to launch commercially in 2016, the ctDNA assay will complement FoundationOne® for solid tumors and FoundationOne® Heme for hematologic malignancies and provide healthcare practitioners with a full suite of analytically validated genomic profiling products to support the application of precision medicine and targeted therapies in cancer care.

    “Tumor tissue obtained by biopsy is the gold standard material from which we generate the requisite molecular information to guide the optimally targeted treatment of patients with cancer,” said Francis Giles, M.D., Deputy Director of the Robert H. Lurie Comprehensive Cancer Center of Northwestern University. “Blood based ‘liquid biopsy’ assays offer the potential to define actionable molecular lesions in patients in whom a tissue specimen can’t be safely obtained or is otherwise unavailable. We’re delighted to be part of this rigorously designed study which we anticipate will help bring a new, less invasive diagnostic option to our patients with cancer.”

  • soundsgood02 soundsgood02 Jul 28, 2015 10:20 AM Flag

    Crede Capital group..
    Crede (Latin): To believe with strong conviction based on careful thought and analysis.

    Direct Equity Investment in Public Companies



    No discounts in direct equity investments.
    Single investor: no "rush to the exits," portfolio companies out perform.
    Crede Capital Group is not a hedge fund guided by short term performance captive capital source.
    Deal terms provide lowest cost of capital for issuers.
    No shorting or hedging employed.
    $5 Million to $50 Million range of investments.

  • soundsgood02 soundsgood02 Jul 28, 2015 10:01 AM Flag

    NO new offer,read the entire filing ...We have prepared this prospectus to allow the Selling Stockholders or their successors, assignees or other permitted transferees to sell or otherwise dispose of, from time to time, up to 3,318,048 shares of our Common Stock. The 3,318,048 shares include the following: (i) 1,473,512 shares of our Common Stock issued pursuant to the Securities Purchase Agreement, dated June 30, 2015, by and among the Company and the Selling Stockholders, or the Securities Purchase Agreement; (ii) 1,177,372 shares of Common Stock issuable upon exercise of the Series A Warrants issued pursuant to the Securities Purchase Agreement; and (iii) 667,164 shares of Common Stock issuable upon exercise of the Series B Warrants issued pursuant to the Securities Purchase Agreement. These Securities were issued in reliance on the exemption from securities registration in Section 4(2) under the Securities Act of 1933, as amended, or the Securities Act, and Rule 506 promulgated thereunder. The exercisability of each of the Series A Warrants and the Series B Warrants is subject to the Warrant Blocker. The Warrant Blocker will automatically expire 61 calendar days prior to the expiration date of the applicable Warrant. The Series A Warrants will not become exercisable until January 7, 2016, and, therefore, the 1,177,372 shares of Common Stock issuable upon exercise of the Series A Warrants will not be offered for sale by the Selling Stockholders until such Series A Warrants are exercisable and exercised by the holders thereof. The Series B Warrants have an exercise price of $0.01 per share of Common Stock and became exercisable upon issuance, except to the extent such exercise is restricted by the Warrant Blocker, and will remain exercisable through January 7, 2021.

    Sentiment: Buy

  • Reply to

    From research to diagnostic....

    by soundsgood02 Jul 15, 2015 3:00 PM
    soundsgood02 soundsgood02 Jul 22, 2015 1:48 PM Flag

    Right,however..Scientific studies about clinical utility of these tests are coming out on daily basis...

  • Reply to

    From research to diagnostic....

    by soundsgood02 Jul 15, 2015 3:00 PM
    soundsgood02 soundsgood02 Jul 22, 2015 11:45 AM Flag

    From Illumina CC..."Different tests complementary"..
    Jay T. Flatley - Chief Executive Officer & Director

    Oh, sure. I mean the question on liquid biopsy is what is the right assay method or combination of assay methods that we know.
    Derik De Bruin - Bank of America Merrill Lynch

    Correct, yeah.
    Jay T. Flatley - Chief Executive Officer & Director

    Aneuploidy will pick up some types of cancers. Nobody quite knows yet the fundamentals of the biology, so we don't know exactly which ones would be picked up by that method versus permutations versus fusions versus methylation. So there's many things we're exploring there, and I think lots of companies are working on this to determine what the best methods might be. And I suspect the market is going to wind up as a whole host of different tests that will be complementary to each other..

  • Reply to

    From research to diagnostic....

    by soundsgood02 Jul 15, 2015 3:00 PM
    soundsgood02 soundsgood02 Jul 17, 2015 11:16 AM Flag

    RESULTS:

    Using custom-made and commercial gene panels containing 8, 50, 190, or 16 000 amplicons, we demonstrate that fast-TT-COLD-PCR enriches mutations on all examined targets simultaneously. Incorporation of deoxyinosine triphosphate (dITP)/2,6-diaminopurine triphosphate (dDTP) in place of deoxyguanosine triphosphate (dGTP)/deoxyadenosine triphosphate (dATP) enables enrichment of Tm-increasing mutations. Serial dilution experiments demonstrate a limit of detection of approximately 0.01%-0.1% mutation abundance by use of Ion-Torrent and 0.1%-0.3% by use of Sanger sequencing.
    CONCLUSIONS:

    Fast-TT-COLD-PCR improves the limit of detection of cancer gene panels by enabling mutation enrichment in multiplex, single-tube reactions. This novel adaptation of COLD-PCR converts subclonal mutations to clonal, thereby facilitating detection and subsequent mutation sequencing.

    Sentiment: Buy

  • Mutation detection will give to liquid biopsy the center of the stage of diagnostic....This company can give something in this field....The big potential partners have no sufficient mutation detection in their machines...

    Sentiment: Buy

  • soundsgood02 soundsgood02 Jul 15, 2015 12:53 PM Flag

    Mutation detection...The key for the future of liquid biopsy...

    Sentiment: Buy

  • soundsgood02 soundsgood02 Jul 14, 2015 5:56 PM Flag

    Bio Rad or Rain Dance...Or illumina...They need to increase mutation sensitivity,still too high to work in
    diagnostic field...This will be the news that could change the story...

    Sentiment: Buy

  • soundsgood02 soundsgood02 Jul 14, 2015 5:44 PM Flag

    Daytraders win another time today...The good news relased recently not enough to reverse long term decline...This news will be the first partnership....Mr kinnon talked about a big one this quarter...Very difficult to know who will be...Qiagen could improve 200 fold the sensitivity even of the recent PyroMark Q24 Advanced...From 2% to 0,01%...
    "Combined with Pyrosequencing(®), which is a very quantitative high-resolution sequencing technology, E-ice-COLD-PCR can detect and identify mutations with a limit of detection down to 0.01 %"

    Sentiment: Buy

  • Transgenomic, Inc. (TBIO), a global biotechnology company advancing precision medicine through advanced diagnostic tests and clinical and research services, today announced the launch of the Transgenomic Leukodystrophy NGS Panel for the diagnosis of leukodystrophy, a group of rare progressive genetic disorders that affect the central nervous system by disrupting the growth or maintenance of the myelin sheath insulating nerve cells.

    Leukodystrophies have typically been difficult to diagnose, with definitive diagnoses taking years of testing. Previously, brain MRI scans were commonly used, but often provided non-specific results. With the advent of improved genetic testing methods, the Global Leukodystrophy Initiative (GLIA) Consortium has issued diagnostic guidelines that recommend use of a broad spectrum next-generation sequencing (NGS) panel, whole exome sequencing, or whole genome sequencing as the preferred first-line diagnostic tool. The new Transgenomic Leukodystrophy NGS Panel includes 137 genes and incorporates all of the genes GLIA recommends for testing. As the most comprehensive test on the market, it can potentially make definitive diagnoses accessible to patients and their families much earlier in the disease process.

    Sentiment: Buy

  • Reply to

    Kinnon/Zygem

    by frobert269 Jul 9, 2015 1:00 PM
    soundsgood02 soundsgood02 Jul 9, 2015 5:21 PM Flag

    Why a new id for a so important opinion..?

    frobert269
    1 post | Last Activity: 4 hours ago Member since: Jul 9, 2015

  • Reply to

    Transgenomic grow and hire...

    by soundsgood02 Jul 6, 2015 12:28 PM
    soundsgood02 soundsgood02 Jul 8, 2015 4:53 PM Flag

    .. Good gain in the May spike....What about your interest here?

    Sentiment: Buy

  • Reply to

    Transgenomic grow and hire...

    by soundsgood02 Jul 6, 2015 12:28 PM
    soundsgood02 soundsgood02 Jul 8, 2015 3:45 PM Flag

    ...Tbio not....Buying more...

    Sentiment: Buy

  • soundsgood02 by soundsgood02 Jul 6, 2015 12:28 PM Flag

    We have the following open positions

    Associate Laboratory Director (Remote Position)
    Authorizations and Collections Specialist (New Haven, CT)
    Staff Accountant – (New Haven, CT)
    Database Administrator – (New Haven, CT)
    Customer Service Representative – (New Haven, CT)
    Genetic Counseling Assistant – (New Haven, CT)
    Application Scientist (New Haven, CT)
    Bioinformatics Scientist (New Haven, CT)
    Scientific Data Analyst (New Haven, CT)

    Sentiment: Buy

  • Reply to

    Evolution of TBIO / Transgenomic

    by ionized1 Jul 1, 2015 7:33 PM
    soundsgood02 soundsgood02 Jul 2, 2015 6:37 PM Flag

    ...Right concepts...However i read the scientific literature,and DANA F.-TBIO cold-pcr is present in at least 20 indipendent scientific studies...With very positive results...It's a"buy" at these prices, imo...

    Sentiment: Buy

  • Reply to

    Evolution of TBIO / Transgenomic

    by ionized1 Jul 1, 2015 7:33 PM
    soundsgood02 soundsgood02 Jul 2, 2015 5:27 PM Flag

    Not shorted Trov @ $13,5?..(around 350 millions in market cap) ..For substance you mean revenue and profit? Not much in the last quarters...

    Sentiment: Buy

  • Reply to

    Evolution of TBIO / Transgenomic

    by ionized1 Jul 1, 2015 7:33 PM
    soundsgood02 soundsgood02 Jul 2, 2015 9:39 AM Flag

    We can do only 1 thing...Buy Tbio if we think is undervalued...

    Sentiment: Strong Buy

PRAN
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