I agree With Jagan here, I too have been in and out in this company and lived through 75 percent of the Deceptions...its like a woman that is unfaithfull but you give her the Benefit of the doubt for too long...like here one doesnt need to see the comp in bed With the pink sheet..Enough is enough, when the ovarian cancer results yielded nothing then one should have walked away. Some obscure insignificant cancer like AML and MDS is where the looser drugs end up, as the solids is where new drugs are really needed. And in solids results just evaporated like for NSCLC and farynx cancer....My advice as both shares have plummeted is to say enough is enough and SELL, and buy Aeterna Zentaris, at least in the latter the ph 3 is still a dream thats not broken yet and its in solid tumors too Endometrial cancer. A swap and a possible recoup. If not a miracle happens its PINKs next for Cycc, dont believe the funds Will be spitting up any more dough.
1) Where are the trials in lung cancer, nasofarynx, and others hidden ?
2) Why use excesive amounts of money on a cancer that isnt at all responding to any therapy. 300 mill out the window on seamless. Wishfull thinking and wastefull thinking.
This company has found out nothing, produced not a single successfull trial and is a Complete fraud going on for more than 10 years.
Is it Turpin on the telephone line, yes we are calling concerning the DSMB peek concerning 108....I have the pleasure of telling you of early termination due to statistic significance, FDA Will preapprove Your drug in accordace With the SPA-agreement. 100 bagger in an Instant, 1000 bagger when the realities sink in among the investing comunity. Hang on...
Dont think a US centre would gamble at least if it was signs its toxic. But remember a drug may work but not make the stat threshold. But I am a believer FDA is corrupt so if it runs Ahead of the readout sell the Stock. If it doesnt run keep it. They never approve a drug if the right folks Arent sitting With nearly 100 percent of the shares. Approved it is a 6 bill a year drug used also off label for untreatable gu cancers. Normally a Stock should run on the readout expectation. However the FDA early stopping due to efficacy comes unexpectedly. Maybe the tree Will be shaken more before a run as the big guys dont like normal folks to make some bucks.
its just like an un happy marriage, the count of disappointments gets to a point where its just hilarius, same With AEZS, its just how many times is the comp to strike it wrongly, its as if they try to fail...
Well 108 has always been the cornerstone and the drug that Will make it a 3000 mill play, and science seems waterproof as always..
The aholes in Ecte just want to Write papers and get fatter on nuttin, we the sharholders wans to get this Device out to the millions of folks that could now be Reading their current blood sugar on the phone.. These folks iecte has to know their time working there is OVER preiod. They try to milk something thats unmilkable. Gt the #$%$ out of Our gem and sell it to China.
Uncle sam used lotsa dolloars to bing forth and then the Chinese biving life to provenge for a fractionof the cost hoard it in, US is just too expensive even to care for their own folks nowadays. US loos China wins, and everybody knows. Congrats
all we need is a call from DSMB saying statistic significance, preaproved 108, then its a 100 bagger. It a whisker away.
Kelly, I agree to all Your comments. What I am pondering is; look at China now they have started hoarding oil as the media say "they buy on the cheap due to the recent decline". Well it isnt cheaper for them as they have to pay for it in a dollar running Wild to the upside. They are hoarding now as the dollar might rise faster than crude may sink. So all commodity purchases Will have to be crammed into a Limited timeframe as the dollar may run much higher. This also worries EU and Japan in which their currency might plummet even further. This could cause a near term spike. Also take into consideration the supply is crippeled as most startups in Canada and Australia are belly up !
Then the largest prducer in europe Ukraine is a total mess. Uranium could spike sooner rather than later in a Perfect storm.
Urre claimed 150 mil pounds of yellowcake PRIOR to the Nucor acquisition and additional acreace is coming Our way in these days. Maybe the total is close to 300 mill punds, which makes ur company the largest player in the american continent. Mcap/per pound is astounding, and in 2007 when Urre traded on fumes it was hardly a viable company. During all these years astounding work has been done on feasibility studies and acqisitions on the cheap, the only We need the spot price to recoup and if history is a reliable guide, once started it goes and goes until parabolic, good luck everyone.
Even if you inject salt water someone Will react emotionally and cause an occational qt -prolongation. Its an odd find and nothing else. Unbelievable that FDA only consists of lawyers and swinders With no Medical know-how.
Noevastat was that fishy compound that didnt work, a long shot it was and a fiasco. Doxy Works we all know that but its cardiotoxic, much less so if the drug is directed into the Cells and not wreacking heavock circulating in the blood stream for a prolonged time. A CBR of 74 percent is amazing and taking into account that many were Taxane resitant, I Will be extremely confused if ph 3 shows nuttin...
if the cancer drug is approved its worh 3 to 6 billions, if its just 10 percent chance of approval thats easily a 300 mill mcap. You are late
Fluffy ideas and lots of disasters along the way, first out was tis sharky idea, not exactly snake oil, it ended in the dumpster. Then the BPH drug tat didnt have an effect, the drug even had a partner. Perifosine was the most mysterious disasters of all time, working well in ph 2 and then nill effect in ph 3. Closest ever is the latest fiasco that may even end up With an NDA next year. Doxy With a hoock on is more Down to Earth if the management hasnt faked ph 2 and diped the histology slides in some fluoresent material, proving doxi went into the cell on false grounds. But I dont think they are that smart, maybe even honest as this electrocardiogram could have been thrown in the dustbin....The company has obtained a near exemplary consistency of skrewing up, all from inception. Well ph 3 in cancer is 17 percent approvals, and small comps maybe 10 percent. Its a gamble, for sure and he doxy which they didnt invent themselves has maybe a higher odds of making it, lets pray...
SPA is violated but thats more or less ok With the FDA as long as a new trial is done to prove its non-toxic. To prove its non toxic is surely possible not to satisfy the SPA, FDA didnt dump it for ever and thats bullish. All in all we got more out of it than we could have hoped for.
I am a hold for now. DSMB going out before the offical peek date in Jan is my dream...AEZS is a 3-6 bill company if Our doxy-conjugate replicates ph 2 results, and this late the DSBM Will preapprove if there is stat significance to be found. This is a very needed cyto, like a wolf in sheeps clothing.
These law firms like Farqui and Farqui, long noses and moneysniffing attitude just live off their phony names and mailbox Offices, supposted by the SEC scamsters to make some kind of phony image of shareholders rights, that are non-existent. Ist all a game and nothing but a game, its rigged, and we have to beat them. Thats all.
..point is doxy in a less toxic admin, is the last resort therapy for all hormonal gu cancers, which impies that if approved it Will be heavily used, even by the Taxane resistant patients. It gives life extension when there are no other optons.
Going against Your own SPA like AEZS did With insufficient specificity in the data could only be labled as corageous and its a positive that the FDA even accepted the Application...yes its a plus, they didnt say no way but found some extra insignificant points to carry the burden of a rejection like the QT-prolongation. Because they know its the best test around, and the only one....Skewing the debate away from the breaking of the SPA towards something that IS repairable opens the window...We phycisians know there is just no way that this coumpound by itself has any cardio or electrolytical effects that can prolong the QT,-hovever the stress of the test situation iteslf surely has....
I think the FDA wants an ultimate approval of the test as there is are better alternatives, the QT problem may be solved easly by injecting the drug on 1000 volunteers that dont have the disease, I would volunteer for 100 bucks any day...
Back to what matters the most, namely the Endo trial; there is just no expectations anymore, but off lable the consequences of an approval for Endo implies enormous Revenues...we all know.
I dont trust readout dates at all, and a continuation of the trial at this stage implies it doesnt work well. We need it to be stopped early due to significant efficacy, thats how it goes....and this messsage could come to us at any time...The readout in January Will just imply a continuation which would make me jump ship...
Its the time just now to scoop it up, pessimism has never before been so profound, but dont trust me I have been wrong before.