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Isis Pharmaceuticals, Inc. Message Board

symptoms88 138 posts  |  Last Activity: 9 hours ago Member since: May 24, 2013
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  • symptoms88 symptoms88 9 hours ago Flag

    what are you talking about Dr. Geisberg was on CNN Saturday morning and basically stated that TKM-E and Z-Mapp were/are the only 2 legitimate drugs and that TKM has already been used on several patients successfully.

  • symptoms88 by symptoms88 Oct 18, 2014 9:41 AM Flag

    It is all about the airborne issue for stocks like APT. If you are astute you will notice that scientists and health care professionals have stopped stating, with certainty, that Ebola is not airborne. They had to stop bc the truth is that they do not know for sure. At the same time, there is enormous pressure on these individuals not to state anything in terms that will panic the public. IMO as the public slowly realizes the reality, and as more health authorities/doctors/scientists have the courage to join the minority who already have begun to state that we just do not know for sure whether ebola is airborne (even if only presenting aerosol danger in very close quarters), that is when stocks like APT and LAKE will take off again. I think it is inevitable that this does occur. For now, most doctors/scientists in the public eye are evasively answering the question of whether they can definitively rule out that ebola is airborne. Dr. Schlesinger on CNBC avoided the question quite artfully on Friday.

  • symptoms88 by symptoms88 Oct 16, 2014 2:29 PM Flag

    This was pinned at OE last month too. Same BS. It will be 25 on Monday.

  • Reply to

    Steak and lobster tonight!

    by instocknow Oct 16, 2014 1:50 PM
    symptoms88 symptoms88 Oct 16, 2014 2:24 PM Flag

    ok. But be sure to stay away from that fancy coffee. Let's not get too ridiculous.

  • symptoms88 by symptoms88 Oct 10, 2014 12:00 PM Flag

    Just watching here bc I am not a day trader but tempted bc fact that LAKE is (to my surprise) holding so strong seems to bode very well for APT to at least hold, and alternatively run much higher. I am trying hard not to pull the trigger here...

  • Reply to

    Hep B drug

    by colie_44875 Oct 9, 2014 3:16 PM
    symptoms88 symptoms88 Oct 9, 2014 4:46 PM Flag

    OR...TKMR's HBV program, which was thought to be a year or more behind ARWR's, will show much better results than ARWR and be considered a frontrunner. I would bet that TKMR's delivery platform delivers much better results. That will/would be worth much more than any of this Ebola hype. You could be looking at a $40 stock in a couple of weeks.

  • symptoms88 symptoms88 Oct 8, 2014 10:52 AM Flag

    I agree with xcohiba entirely. Contrast NVAX with a company like OXGN, in which I have also invested and which has had a remarkably successful clinical trial result, but still has no leverage for money raise or takeover bc they have like 7 employees and they can't even feign that they will go it alone. Thus greatly diminished bargaining power despite a potential blockbuster product (zybrestat). NVAX is going to have both the product and the bargaining power bc they have taken every step to prove that they can and will, absent an extra-ordinary partnership or buyout, go it alone.

  • Reply to

    Nebraska Drs. Succumb To CDC/FDA?

    by tar262weir333 Oct 7, 2014 3:40 PM
    symptoms88 symptoms88 Oct 7, 2014 8:23 PM Flag

    No I can't totally agree bc you presume the Doctor has the ability to "prescribe" the drug of his choice. In the case of Ebola, there is very limited supply of TKM-E and you likely have to go through the CDC, FDA, TKMR itself, and god knows who or what else before you even have the option to prescribe the drug. So, without any real supply of anything that has proven efficacy even in animals, they are what I would call "stepping down" to less proven drugs with more availability, and now using them, assuming of course that at a minimum the drug won't, as you say, cause more harm than good.

  • Reply to

    Nebraska Drs. Succumb To CDC/FDA?

    by tar262weir333 Oct 7, 2014 3:40 PM
    symptoms88 symptoms88 Oct 7, 2014 5:02 PM Flag

    I of course am concerned on a human level too, but we have to accept the fact that some people are going to die regardless of what drug they receive. There are many illnesses which are incurable, or incurable when a person is on their deathbed. The fact that any one person lives or dies from ebola is much too small a sample to determine whether a drug is efficacious, despite the overreaction by the public over every single outcome. Of course this goes both ways. The fact that Dr. Sacra (and likely others who have taken TKM-E) lived does not tell me that TKM-E will ultimately be the drug of choice.

  • Reply to

    Nebraska Drs. Succumb To CDC/FDA?

    by tar262weir333 Oct 7, 2014 3:40 PM
    symptoms88 symptoms88 Oct 7, 2014 4:39 PM Flag

    Nebraska never even said that the CDC/FDA gave them TKMR as an option with this patient. This is being widely misinterpreted. Nebraska chose the best available option but likely were given very few, and TKM-E was likely not among them. Again, to me the notion that anyone would choose a drug tested in a tube over a drug proven to save lives of primates and already successfully used in humans is ridiculous. If I am shown to be wrong I will come out and say so, but I doubt it. Much more likely that all available supply of TKM-E has been used or accounted for in the planned human trials.

  • Reply to

    TKMR vs CMRX

    by invisiblecurrency Oct 7, 2014 9:02 AM
    symptoms88 symptoms88 Oct 7, 2014 2:10 PM Flag

    PS: i do accept that the price decline is an indicator. This is how i make my money-on the public's failure to accurately comprehend the subtleties in words. Great example when at TKMR's conference call management said (paraphrased) that there "currently is no accepted clinical/regulatory pathway for use of TKM-E". The PPS tanked bc peeps like u misinterpreted that to mean that management was citing to a regulatory barrier for TKM-E. The truth was more akin to mngmt citing a broad truth for all Ebola drugs. Peeps were too dumb to realize that that truth was not a barrier (it couldn't be bc otherwise Z-MAPP could not have been used. Rather, TKMR WANTED a regulatory path so they could test the drug and have data under established protocols before using the drug. SO, I loaded up and what happened next? Rhetorical.

  • Reply to

    TKMR vs CMRX

    by invisiblecurrency Oct 7, 2014 9:02 AM
    symptoms88 symptoms88 Oct 7, 2014 2:02 PM Flag

    I read the reports and as i said you are exactly wrong. Nowhere does it say that Nebraska was given TKM-E as an option. Nowhere does it say that TKM-E was "denied" by choice of the hospital or the patient.They said the drug being used, among their options, was their "best" option. Like i said words are important. You misuse them. The WHO indicated that their were 30 TX course available of TKM-E and that was about 4 weeks ago. TKM-E has been quietly used on any number of patients since then. Supply could be almost non-existent at this point. Again i have no idea where people get the notion that every single Ebola patient, even if American, (there are thousands) is going to be offered a treatment course of TKM-E. Also what about the consortium for clinical trials that TKM-E is a part of. Don't you think you actually need some of the drug to participate in that?

  • Reply to

    TKMR vs CMRX

    by invisiblecurrency Oct 7, 2014 9:02 AM
    symptoms88 symptoms88 Oct 7, 2014 1:38 PM Flag

    Ummmmmm....Source? and "denied" by whom? Words are important. I have no idea what u are referring to but would still bet my balls it or you are misleading and inaccurate.
    I "just announced" you are full of - - - -. Should people buy and sell securities based on that "announcement"?

  • Reply to

    GSK chairman just on CNBC...

    by symptoms88 Oct 7, 2014 8:07 AM
    symptoms88 symptoms88 Oct 7, 2014 12:25 PM Flag

    Yes and not to mention the NBC cameraman that was supposedly using extreme caution. (he caught ebola while cleaning a car?), and the nurse in Spain, and the Nigerian fellow who singlehandledly gave Ebola to about 10 people. Exchange of bodily fluids my #$%$. This is complete and total #$%$

  • Reply to

    GSK chairman just on CNBC...

    by symptoms88 Oct 7, 2014 8:07 AM
    symptoms88 symptoms88 Oct 7, 2014 12:06 PM Flag

    Well nobody seems to be trying to create any degree of fear. IMO everyone from the top down that is knowledgeable is lying by saying that Ebola is difficult to spread. These lies are then repeated by the media again and again. When these lies stop maybe we can start dealing with reality.

  • Reply to

    TKMR vs CMRX

    by invisiblecurrency Oct 7, 2014 9:02 AM
    symptoms88 symptoms88 Oct 7, 2014 11:44 AM Flag

    Where do people find this stuff to make up? The notion that any patient would refuse TKM-E in favor of a drug that has only been tested in a tube is absurd. There are possibly less than 30 treatment courses of TKM-E available and THOUSANDS of people have the ebola virus. What in hell makes anyone think everyone with Ebola is being offered TKM-E? This is especially true in light of the fact that TKM-E is, in effect, running a clinical trial right now. TKMR certainly would have to agree to provide the drug to any particular patient. Not to mention a final point that it would be TERRIBLE public policy to offer what is without question the most efficacious available ebola therapeutic to any person who snuck into our country after being knowingly exposed to Ebola. You might as well send Ebola patients a VIP invite to surreptitiously enter the USA.

    Sentiment: Strong Buy

  • Reply to

    Pre-clinical timeframe

    by honest_abe_5 Oct 6, 2014 9:13 PM
    symptoms88 symptoms88 Oct 7, 2014 8:17 AM Flag

    Yeah I agree, Much less likely that FDA will allow untested vaccines before untested therapeutic drugs...but I suppose it depends on just how out of control the situation gets...

  • talking about how it will take them, in relative terms, a long time to produce an ebola vaccine, especially on an industrial scale.

  • symptoms88 by symptoms88 Oct 7, 2014 8:04 AM Flag

    The fact that the FDA is allowing use of drugs that have not even been animal tested shows how bad the situation has become. No possible way that the Texas guy chose such a drug over TKM-E. I don't know why it wasn't made available to him, but IMO it was not. There are going to be more and more players but it is not an indication of more and more promising therapeutic drugs, rather it is an indication that the situation is more and more dire and the government is ready to try just about anything at this point, even if it has only shown promise in a test tube, because there are not enough doses (hardly any really) of effective animal tested drugs (like TKM-E) currently available.

  • Reply to

    Pre-clinical timeframe

    by honest_abe_5 Oct 6, 2014 9:13 PM
    symptoms88 symptoms88 Oct 7, 2014 7:50 AM Flag

    One note-Animal testing is not a pre-requisite at this point, so the time frame for human use, whatever it is, does not necessarily include that. The drug that the Dallas patient is taking was never used on animals and only showed efficacy in the test tube. This shows how bad the situation is, and how few doses of the animal tested drugs (like tkmr) are available. Of course not sure how differently, if at all, the FDA would treat a vaccine versus a therapeutic.

ISIS
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