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Synta Pharmaceuticals Corp. (SNTA) Message Board

teresadactyl 6 posts  |  Last Activity: Apr 3, 2015 4:28 PM Member since: Jul 29, 1999
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  • Reply to

    Huge implied endorsement on PBS Cancer Special

    by teresadactyl Apr 2, 2015 10:05 AM
    teresadactyl teresadactyl Apr 3, 2015 4:28 PM Flag

    My goodness. Such a torrent of specious logic. You must be short a ton of shares. LBIO became NNMS just weeks ago. It is barely on institutional radar. By your own admission, the CART-T/TCR space has become totally overinvested and a very crowded trade. Not so TIL. LBIO has appreciated ~ 100 percent in 6 months. That is hardly languishing . Are we to believe an anonymous YMB charlatan...or PBS?

    Sentiment: Strong Buy

  • Last night. Ph 2 trial at NCI covered extensively. That is LBIO . See Feb 2014 press release

  • teresadactyl by teresadactyl Mar 26, 2015 3:08 PM Flag

    From the release...

    " The baseline elevation in cCK18 confirmed that the underlying targets of emricasan's mechanism, apoptosis and inflammation, which are believed to drive liver disease progression, were engaged in the NAFLD/NASH patients in this trial. A reduction from baseline in cCK18 at Day 28 of approximately 30% in the emricasan treatment arm and an increase from baseline of approximately 4% in the placebo arm"

    Why did they not give p values for this result?

    Dumb !!

  • teresadactyl by teresadactyl Mar 16, 2015 10:06 PM Flag

    "Based on the funds we had available on December 31, 2014 and the additional net proceeds we received in the March 3, 2015 public offering, we believe that we have sufficient capital to fund our anticipated operating expenses for at least 24 months."

    Sentiment: Strong Buy

  • Reply to

    Why did the share price drop from $10 to $5 ?

    by sootagain Feb 1, 2015 11:14 AM
    teresadactyl teresadactyl Feb 1, 2015 2:29 PM Flag

    NASH data not out yet. Due this quarter. Reason for drop IMO was a very confusing press release about Jan 8. results for acute-on-chronic liver failure (ACLF) that many misread. The data was was Emricasan's seven-fold reduction in biomarker cCK18 over Placebo (54% to 7%) that many misread as 54% to merely 44%. I am a professional writer and it took even I three reads of the release to get it right.

  • Results for the upcoming Emricasan Phase 2 NAFLD/NASH trial are expected soon -- Q1 of 2015. As reported in CNAT’s Sept. 2, 2014 update presentation, the primary efficacy variable in this trial is change from baseline in ALT. See slide #24.

    We already have a compelling example of Emricasan’s ability to change (lower) the ALT from baseline in a VERY big way. Where is that?


    As also reported in CNAT’s Sept. 2, 2014 update presentation, in the Phase 2b Dose Response Study in HCV Patients (Study A8491003), Emricasan’s reduction in ALT over placebo in HCV patients was HUGELY statistically significant (stat sig) -- with a “p” value of .0001 (the lower the better). See slide # 12.

    I predict the NAFLD/NASH trial results will be similar to the HCV trial results. Stat sig – and out of the park.

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