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tfrd2233 4 posts  |  Last Activity: Jun 4, 2015 7:17 AM Member since: May 23, 2006
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    last time they had no contract mfg.

    by tomrus67 May 8, 2015 10:20 AM
    tfrd2233 tfrd2233 May 8, 2015 6:37 PM Flag

    If you lost a ton on this you bought to high ,That is not a problem now is it, No help needed Thanks

  • tfrd2233 by tfrd2233 May 8, 2015 11:07 AM Flag

    I cant see the forest all the trees are in the way

  • tfrd2233 by tfrd2233 Apr 14, 2015 4:34 PM Flag

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    Medfield Doctor Sets Paradigm For Transplants
    Dr. Hemant Thatte of Medfield has created a new product that will change the way that transplants are approached around the world. (Photo courtesy of Hemant Thatte)
    Dr. Hemant Thatte of Medfield has created a new product that will change the way that transplants are approached around the world. (Photo courtesy of Hemant Thatte)
    BY JOSH PERRY (@Josh_Perry10) • Mon, Oct 27, 2014
    In the October issue of the “American Journal of Transplantation,” one of the leading journals about transplant surgery in the world, Medfield resident Dr. Hemant Thatte has published three papers, including a cover story, describing the results of his work that could provide a radical shift in the way that heart transplants are performed around the world.

    Thatte, who is a Professor of Cardiothoracic Surgery at Harvard Medical School and the Director of Cardiac Surgery Research at the VA Hospital in West Roxbury, has developed a solution that allows hospitals to store hearts at room temperature, rather than at four degrees Celsius, and to preserve them for 24 hours, instead of the current standard of four hours.

    “It’s a huge leap,” said Thatte in an interview with Hometown Weekly in early October. “In 24 hours you can reach any part of the globe with today’s travel capabilities.”

    Thatte came to Harvard in 1988 from Stanford Medical School and he began researching better ways to preserve blood vessels for use in heart transplant surgery. According to Thatte, the standard was to store the vessel in a lidocaine solution or analogous blood from the patient. Even with current medical practices, there was still a 48 percent failure rate for bypasses within the first year after surgery.

    “The technology that I have developed, what we call GALA, allows us to preserve these grafts in perfectly viable condition outside the body during open heart surgery,” explained Thatte. “The longterm effect of these grafts because they were preserved using my technology leads to better longterm outcomes.”

    GALA, which is being marketed as DuraGraft by the company Somahlution, can save hospitals millions because patients will not require multiple surgeries or large medication regimen after a bypass. “More than the money,” said Thatte, “is the morbidity (rate of sickness) of these patients because they don’t have to go through all these surgeries.”

    DuraGraft was released in a number of countries around the world this month after receiving the CE Mark from the European Union. It is undergoing clinical trials in the U.S. and Thatte is hopeful that the FDA will also be approving the product for domestic release by the end of the first quarter of 2015.

    “The only hope is that it benefits the patient because I believe in the technology,” reflected Thatte. “I’ve seen it work; so why would you not use it for your patients?”

    GALA, which Thatte described as a physiological salt solution, is different from previous attempts at preserving blood vessels because it works on a biochemical level to create an environment in which the vessels maintain energy, avoid the creation of free radicals, maintain muscle movement, and continue to operate as though still in the circulatory system.

    By creating a solution that avoids damaging the vessels through the shock of cold storage or exposing them to free radicals, Thatte said, “that whatever happens downstream is taken care of…that if there is an injury to the vessel or organ that it can repair itself.”

    He continued, “The whole concept all these years had been utilizing synergistic pathways in the human body to create enough energy so that even if the heart is sitting outside the body then it is able to create energy and take on the work once it is transposed.”

    After working for years on blood vessels and bypass surgeries, Thatte was able to turn his attention to the heart. In this country alone, there are more than 100,000 patients waiting for heart transplants and Thatte said that 17 transplant patients per hour are dying because there is a vast shortage of organs.

    Through his research on GALA, Thatte created Somah solution to keep organs at room temperature for a full 24 hours, while still producing energy. This means that when the organ is placed back into the body of a transplant recipient it does not require multiple shocks and drugs to get started; it has maintained its energy while in the solution.

    “Imagine a heart that has been kept out of the body, out of circulation, like that for four hours,” said Thatte. “What do you expect and why have people not thought about that? It causes a tremendous amount of injury.”

    Have you ever seen a heart start beating in a bucket in a lab at room temperature? Neither had any of the researchers on Thatte’s team at the VA, but now that video is on YouTube as stunning proof of what can be accomplished using the solution that Thatte developed.

    “Even now, every time that I see a heart start I get goose bumps because it’s a dead heart that comes to life through this technology,” he remarked. “And when we stored the heart for 24 hours and came back the next day and it started…everything came to a standstill because that is unheard of.”

    Somahlution and DuraGraft were exhibited at the EACTS 28th annual meeting in Milan, Italy last week to launch the product in Europe. The product and its application to transplant surgery have already drawn the attention of surgeons and hospitals around the world.

    Thanks to his research, Thatte has changed the way that transplant surgeries will be approached. He has created a paradigm shift for his field.

    If hearts, and eventually other organs as well, can be stored at room temperature for a day then there will no longer be the need for the 2 a.m. phone calls and emergency surgeries in the early morning. Also, there will now be the time to find perfect matches rather than simply making sure of a blood type pairing. With more time, transplants should be more successful in the long-term and require fewer additional surgeries or extensive drug treatments.

    Thatte concluded, “It’s not just an intellectual pursuit anymore. It has become a practical reality.”

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