Just because Adam F. said this doesn't mean that it's going up-- talk about ridiculous! So-called experts get it wrong all the time; it was just his opinion, nothing more. We will be overshadowed by the Penn News, IN MY OPINION.
Never been to Arkansas but close (Tennessee); I'll take the snow over tornadoes, however. I am very new to GERN, purchased stock last week. I was really excited reading about the upcoming ASH conference until last evening when I read about another study by another company with spectacular results dealing with gene therapy. What's your thought on GERN? I'm just asking for your gut feeling, knowing full well that anything you say is just that. TIA
regular market hours? I personally believe pre-market and after-market a scam which favors the rich and those who are professionals at trading; the little guy mostly doesn't know or understand trading in the pre and post period and the dangers inherent in trading in those times-- prices that jump up and down on small trades, etc. Look how this stock zoomed up in pre-market hours this past Friday only to level back down by opening. So, somebody made so big bucks in pre-market selling and the average Joe, or Jane, got left with nothing. Just doesn't seem fair. Another irritation of mine is delayed by 15-minute quotes in pps. Yes, I understand that people can find real time quotes but why in this digital age have any delayed quotes, or news for that matter? Just more manipulation by the rich and powerful, in my opinion. I guess it will always be that way, however. Ho, hum, life marches on.
Do you think GERN was blindsided by the Penn news? What a coincidence that GERN had very positive news that was released early accidently and then comes along this Penn news with national coverage last evening which sounds historic, too. Go figure, just when you think you've got it all figured out all these twists and turns happen; and I might add, not by coincidence, in my honest opinion!
The treatment can cause severe flu-like symptoms and other side effects, but these have been reversible and temporary, doctors say.
Penn doctors have treated the most cases so far — 59. Of the first 14 patients with CLL, four had complete remissions, four had partial ones and the rest did not respond. However, some partial responders continue to see their cancer shrink a year after treatment.
"That's very unique to this kind of therapy" and gives hope the treatment may still purge the cancer, said Porter. Another 18 CLL patients were treated and half have responded so far.
Penn doctors also treated 27 ALL patients. All five adults and 19 of the 22 children had complete remissions, an "extraordinarily high" success rate, said Dr. Stephan Grupp at the Children's Hospital of Philadelphia.
Six have since relapsed, though, and doctors are pondering a second gene therapy attempt.
At the National Cancer Institute, Dr. James Kochenderfer and others have treated 11 patients with lymphoma and four with CLL, starting roughly two years ago. Six had complete remissions, six had partial ones, one has stable disease and it's too soon to tell for the rest.
Ten other patients were given gene therapy to try to kill leukemia or lymphoma remaining after bone marrow transplants. These patients got infusions of gene-treated blood cells from their transplant donors instead of using their own blood cells. One had a complete remission and three others had significant reduction of their disease.
"They've had every treatment known to man. To get any responses is really encouraging," Kochenderfer said. The cancer institute is working with a Los Angeles biotech firm, Kite Pharma Inc., on its gene therapy approach.
Researchers at Memorial Sloan-Kettering Cancer Center will report on 13 patients with ALL; the University of Texas MD Anderson Cancer Center will report about two-dozen patients with ALL or lymphoma, and Baylor University will give results on 10 patients with lymphoma or myeloma.
Patients are encouraged that relatively few have relapsed.
"We're still nervous every day because they can't tell us what's going to happen tomorrow," said Tom Whitehead, 8-year-old Emily's father.
Doug Olson, 67, a scientist for a medical device maker, shows no sign of cancer since gene therapy in September 2010 for CLL he had had since 1996.
"Within one month he was in complete remission. That was just completely unexpected," said Porter, his doctor at Penn.
Olson ran his first half-marathon in January and no longer worries about how long his remission will last.
"I decided I'm cured. I'm not going to let that hang over my head anymore," he said.
Doctors are reporting unprecedented success by using gene therapy to transform patients' blood cells into soldiers that seek and destroy cancer.
In one of the biggest advances against leukemia and other blood cancers in many years, doctors are reporting unprecedented success by using gene therapy to transform patients' blood cells into soldiers that seek and destroy cancer.
A few patients with one type of leukemia were given this one-time, experimental therapy several years ago and some remain cancer-free today. Now, at least six research groups have treated more than 120 patients with many types of blood and bone marrow cancers, with stunning results.
"It's really exciting," said Dr. Janice Abkowitz, blood diseases chief at the University of Washington in Seattle and president of the American Society of Hematology. "You can take a cell that belongs to a patient and engineer it to be an attack cell."
In one study, all five adults and 19 of 22 children with acute lymphocytic leukemia, or ALL, had a complete remission, meaning no cancer could be found after treatment, although a few have relapsed since then.
Related: Childhood cancer survivors face heart risks soon after treatment
These were gravely ill patients out of options. Some had tried multiple bone marrow transplants and up to 10 types of chemotherapy or other treatments.
Cancer was so advanced in 8-year-old Emily Whitehead of Philipsburg, Pa., that doctors said her major organs would fail within days. She was the first child given the gene therapy and shows no sign of cancer today, nearly two years later.
Results on other patients with myeloma, lymphoma and chronic lymphocytic leukemia, or CLL, will be reported at the hematology group's conference that starts Saturday in New Orleans.
Doctors say this has the potential to become the first gene therapy approved in the United States and the first for cancer worldwide. Only one gene therapy is approved in Europe, for a rare metabolic disease.
The treatment involves filtering patients' blood to remove millions of white blood cells called T-cells, altering them in the lab to contain a gene that targets cancer, and returning them to the patient in infusions over three days.
"What we are giving essentially is a living drug" — permanently altered cells that multiply in the body into an army to fight the cancer, said Dr. David Porter, a University of Pennsylvania scientist who led one study.
Several drug and biotech companies are developing these therapies. Penn has patented its method and licensed it to Switzerland-based Novartis AG. The company is building a research center on the Penn campus in Philadelphia and plans a clinical trial next year that could lead to federal approval of the treatment as soon as 2016.
Talking with the researchers, "there is a sense of making history ... a sense of doing something very unique," said Hervé Hoppenot, president of Novartis Oncology, the division leading the work.
Related: Gene study uncovers origins of many common cancers
Lee Greenberger, chief scientific officer of the Leukemia and Lymphoma Society, agreed.
"From our vantage point, this looks like a major advance," he said. "We are seeing powerful responses ... and time will tell how enduring these remissions turn out to be."
The group has given $15 million to various researchers testing this approach. Nearly 49,000 new cases of leukemia, 70,000 cases of non-Hodgkin lymphoma and 22,000 cases of myeloma are expected to be diagnosed in the United States in 2013.
Many patients are successfully treated with chemotherapy or bone marrow or stem cell transplants, but transplants are risky and donors can't always be found. So far, gene therapy has been tried on people who were in danger of dying because other treatments failed.
The gene therapy must be made individually for each patient, and lab costs now are about $25,000, without a profit margin. That's still less than many drugs to treat these diseases and far less than a transplant.
With about 45 minutes remaining for the day how can you honestly write that "it may close near the midpoint of the range at $6.72"-- that would be a freak in miracle given the time! Way too rosy!
No, it's the negative news piece just put out by Motley-- go read it.
Congrats to you, I stupidly sold when it went from .12 to .48! I almost got back in before this meeting but I felt uneasy and so I missed out. Nonetheless, I'm happy for all those who made lots of money. Yeah, I think mutual funds are a joke, my wife's mutual funds have been treading water for years now and have only recently made it back to pre-recession levels. Congrats to you!
Sounds promising, is there an exact date for that determination? TIA
The company needs to ship 3,000 units next year for earnings before interest, taxes, depreciation and amortization to reach break even, according to the statement.
Does anyone know how much one unit is? Just curious. TIA
Nothing is a safe bet! You should say that your hunch is this is a safe bet-- that would be more accurate.
What do you think will transpire on December 4th? People around here seem to expect something major. Will they address the delisting or extension? TIA