Recent

% | $
Quotes you view appear here for quick access.

Synthetic Biologics Inc. Message Board

tradingmeansfreedom 85 posts  |  Last Activity: Aug 1, 2015 7:21 PM Member since: Jun 27, 2008
SortNewest  |  Oldest  |  Highest Rated Expand all messages
  • tradingmeansfreedom tradingmeansfreedom Aug 1, 2015 7:21 PM Flag

    I've been through the press releases, patents and clinical trial files. As far as I know, Dr. Voskuhl is using natural estriol in the studies, not a BHRT compound. Our future success is all about the patent rights to treat autoimmune diseases and cognitive restoration. I don't think there's a lot of debate about whether estriol works or not, anecdotally, it's amazing.

    Sentiment: Strong Buy

  • tradingmeansfreedom tradingmeansfreedom Jul 28, 2015 11:54 AM Flag

    The key word there is "prevents". With Big Pharma, ALWAYS follow the money. Treating means the company is limited to a small segment that is actually showing symptoms ($). Prevention means "PREtreating" everyone that might show symptoms. ($$$$$$). Think vaccinations and annual flu shots.

    Having said that, I still think there is a tie-in between C Diff and Dr. V's MS work.

    Sentiment: Strong Buy

  • Reply to

    ALL TIME HIGH CLOSE(3.35)

    by success_now62 Jul 27, 2015 5:18 PM
    tradingmeansfreedom tradingmeansfreedom Jul 27, 2015 5:28 PM Flag

    Jul 14, 2015 $4.00
    Jul 15, 2015 $3.76

    Sentiment: Strong Buy

  • Reply to

    watch and learn 2:30 pm

    by chasball147 Jul 27, 2015 10:53 AM
    tradingmeansfreedom tradingmeansfreedom Jul 27, 2015 2:36 PM Flag

    You are truly an idiot.

    Sentiment: Strong Buy

  • Reply to

    Connecting the dots..

    by rc248 Jul 24, 2015 4:19 PM
    tradingmeansfreedom tradingmeansfreedom Jul 24, 2015 4:32 PM Flag

    and "Let's see: What other MS related stuff might be in SYN's pipeline? Maybe Acinetobacter?"

    Sentiment: Strong Buy

  • Reply to

    Connecting the dots..

    by rc248 Jul 24, 2015 4:19 PM
    tradingmeansfreedom tradingmeansfreedom Jul 24, 2015 4:32 PM Flag

    See "More SYN secrets for you: Have you heard about the MS-gut Archaea biome link research?"

    Sentiment: Strong Buy

  • tradingmeansfreedom tradingmeansfreedom Jul 24, 2015 3:32 PM Flag

    The first SYN/Intrexon collaboration focused on providing access to Intrexon's UltraVector platform as well other XON technology. One of those technologies is Rheoswitch:

    "RheoSwitch® gene regulation delivers precise rheostatic control and optimizes performance in multiple biological systems (human, animal, yeast, and plant) for a diverse range of applications, including gene therapy, biotherapeutics, and agriculture. The RheoSwitch Therapeutic System® (RTS®) offers transcriptional control of a wide variety of therapeutic genes by regulating the timing and dose of an oral activator ligand."

    Sentiment: Strong Buy

  • Interesting that even though we're working with the world's leading MS researcher, no mention is made of searching for possible synergies amongst the various products in our pipeline. Weird, huh?

    ***

    Study: The role of Acinetobacter in the pathogenesis of multiple sclerosis examined by using Popper sequences. 2012 Ebringer A1, Rashid T, Wilson C.

    "Conclusions: These nine Popper sequences suggest that ** MS is most probably caused by infections with Acinetobacter bacteria in the nasal sinuses, and this could have therapeutic implications. **"

    Book: Multiple Sclerosis, Mad Cow Disease and Acinetobacter Hardcover – November 20, 2014

    "The aim of this book is to publicise and bring to a wider audience the concept that the cause of two neurological diseases, namely multiple sclerosis (MS) and “mad cow disease” also known as “bovine spongiform encephalopathy” are related through exposure to a common microbe Acinetobacter which is found in human sinuses, on skin and in the soil. "

    Sentiment: Strong Buy

  • tradingmeansfreedom tradingmeansfreedom Jul 24, 2015 2:44 PM Flag

    An animal model of cortical and callosal pathology in multiple sclerosis.
    Mangiardi M1, Crawford DK, Xia X, Du S, Simon-Freeman R, Voskuhl RR, Tiwari-Woodruff SK.

    "The chronic EAE mouse model has features that mimic cortical and callosal pathology of MS, and can be potentially used to screen agents to prevent these features of disease."

    Sentiment: Strong Buy

  • tradingmeansfreedom tradingmeansfreedom Jul 23, 2015 6:35 PM Flag

    Thanks. I never assume that what I'm told by salespeople, corporations or governments is the whole story. Just spin.

    Sentiment: Strong Buy

  • tradingmeansfreedom tradingmeansfreedom Jul 23, 2015 6:21 PM Flag

    To be fair, the 3 digit predictions were a lot easier when we only had 28M shares outstanding, back when I went long.

    Sentiment: Strong Buy

  • tradingmeansfreedom tradingmeansfreedom Jul 23, 2015 5:51 PM Flag

    That was my favorite quote by Dr. Pimentel with the vague phrasing: "Our group has continued to uncover and increasingly appreciate the role that intestinal archaea play in ** highly prevalent diseases **... I am excited to be working with SYN to develop potential breakthrough pathogen-specific approaches ** for these major disease indications **."

    Seems like he may not be as comfortable out and out lying to investors as *some* SYN management seems to be.

    Sentiment: Strong Buy

  • tradingmeansfreedom tradingmeansfreedom Jul 23, 2015 5:47 PM Flag

    There's nothing set in stone, and I don't think it's set in stone that they have to use the $ for other products, that's covered under safe harbor. Also, see my post on "SYN Secrets" and the biome, I also think that the gut stuff is related to MS whether management divulges that or not.

    Sentiment: Strong Buy

  • tradingmeansfreedom tradingmeansfreedom Jul 23, 2015 5:29 PM Flag

    From a SYN slide deck:

    "SYN APPROACH: Anti-Archaea specific therapeutic"

    And what type of Archaea does Dr. Pimentel specialize in?

    "Kim Gene, Deepinder Fnu, Morales Walter, Hwang Laura, Weitsman Stacy, Chang Christopher, Gunsalus Robert, Pimentel Mark ** Methanobrevibacter ** smithii is the predominant methanogen in patients with constipation-predominant IBS and methane on breath."

    And remember, Dr. Pimentel & Dr. Voskuhl are both part of the David Geffen School of Medicine at UCLA. Very handy for covert collaboration without raising a red flag to say "HEY, LOOK, BOTH OF US SYN-RELATED TOP RESEARCHERS ARE COLLABORATING. WHAT A COINCIDENCE THAT A MARYLAND BASED COMPANY HAS 2 COLLABORATIONS WITH CALIFORNIA BASED SCIENTISTS".

    Sentiment: Strong Buy

  • tradingmeansfreedom tradingmeansfreedom Jul 23, 2015 5:04 PM Flag

    6 thumbs down for simply posting a list of autoimmune diseases that would be covered by our licensing agreement to UCLA's patents? How odd.

    Sentiment: Strong Buy

  • tradingmeansfreedom tradingmeansfreedom Jul 23, 2015 4:56 PM Flag

    You have much more faith in the Federal Big Pharma Enforcement Thugs Administration than I do. Since when has the FDA explained any of their baffling arbitrary decisions to anyone?

    An article chunk from 2008: "Now why would Wyeth complain to the FDA about compounding pharmacists using a natural hormone, Estriol, to help women with hormone balancing? Surely you're not surprised that it has to do with money . . . Wyeth is the pharmaceutical giant, whose sales have plummeted, from their products Premarin and PremPro when the Women's Health Initiative (WHI) found that they caused heart disease, strokes and cancer. Women that have suffered from the use of these drugs are suing Wyeth and winning millions in damages in courtrooms across the U.S."

    Sentiment: Strong Buy

  • Coincidence? lol

    **
    From Scientific American: Could Multiple Sclerosis Begin in the Gut?

    One study presented at the conference, out of Brigham and Women’s Hospital (BWH), reported a single-celled organism called methanobrevibacteriaceae that activates the immune system is enriched in the gastrointestinal tracts of MS patients whereas bacteria that suppress immune activity are depleted.

    Wait, what are these methanobrevibacteriaceae things? Let's see:

    Specifically, they found that MS patients had an increased number of *** Archaea*** species, particularly of the family *** Methanobrevibacteriaceae ***, which normally comprises about 10 percent of the gut population. Their mean relative abundance was 6.6-fold higher in MS patients compared with controls.

    Another study:

    Increased *** Archaea *** Species and Changes with Therapy in Gut Microbiome of Multiple Sclerosis Subjects
    CONCLUSION: Our results identify changes in both pro-and anti-inflammatory epigenetic factors in the gut microbiome of MS subjects that may contribute to disease pathogenesis.

    So, latest MS research says Archaea and MS are related? Well then, I'm sure that this collaboration and press release is absolutely, unequivocally completely unrelated, and if there was such a link SYN management would tell the world so that our stock price would shoot up:

    Synthetic Biologics, Inc. (NYSE MKT: SYN), a developer of product candidates focused on the prevention and treatment of serious infectious diseases and other diseases, announced today that it entered into worldwide license and option agreements with Cedars-Sinai Medical Center ("Cedars-Sinai") for the development of new treatment approaches to target non-bacterial intestinal microorganism life forms known as *** archaea ***

    Have a good day, fellow millionaires.

    Sentiment: Strong Buy

  • tradingmeansfreedom tradingmeansfreedom Jul 23, 2015 4:15 PM Flag

    Also, why do you think lupus wouldn't respond well? Lupus does cause damage to the myelin sheath, and estriol should theoretically help regenerate the sheath, if the cognitive results turn out to be as specific as that. The myelin in the brain aren't any different than the rest of the body. Which of course has greater implications to other demyelination issues like carpal tunnel and spinal trauma. There are numerous projects under way to regrow myelin in general. Carpal treatment alone would be a blockbuster in sales potential in our white collar workforce. Our horizon is bright, it just hinges on the patent coverage.

    Sentiment: Strong Buy

  • tradingmeansfreedom tradingmeansfreedom Jul 23, 2015 3:58 PM Flag

    There's still the FDA to contend with, but I think a Big Pharma licensing partner or perhaps Kirk will resolve that issue, um, one way or another. They just have to outbid Wyeth's FDA lobbyists.

    Sentiment: Strong Buy

  • Reply to

    Large buy

    by tdogbadger Jul 23, 2015 3:37 PM
    tradingmeansfreedom tradingmeansfreedom Jul 23, 2015 3:42 PM Flag

    What it really means is that someONE spent about $150K in one fell swoop rather than trying to slowly and quietly accumulate, for some reason.

    Sentiment: Strong Buy

SYN
3.23-0.07(-2.17%)Aug 3 4:01 PMEDT