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Omeros Corporation Message Board

tredleon 77 posts  |  Last Activity: Aug 31, 2015 5:55 PM Member since: Sep 21, 1999
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  • tredleon tredleon Aug 25, 2015 5:59 PM Flag

    Simple - 192wk and dystrophin data at WMS meeting in early Oct and then the AdCom meeting in Nov. Not saying it might not be volatile, but it will be above $48 by Thanksgiving.

  • Reply to

    BMRN's potential first-to-market advantage

    by neo17a Aug 24, 2015 7:20 PM
    tredleon tredleon Aug 25, 2015 8:37 AM Flag

    Yeah, money and a fancy marketing brochure is going to change doctors' and parents' minds about what is the safest and most effective drug for their terminally ill child. Even if marketing muscle was important in this situation, which it is not, it's not as if BMRN didn't have the financial resources prior to the MDVN deal to market Drisa aggressively. They can throw as much money as they want at Drisa - it will always be an inferior choice to Etep.

  • tredleon tredleon Aug 24, 2015 3:15 PM Flag

    Thanks, jrrt. I hope the FDA assesses the 6MWT data in the same manner that you have, but I think the dysrophin data is even more important - not just in providing further evidence to support approval, but in providing a clear distinction between Etep and Drisa. The idea that you can have an effective drug without providing evidence of dystrophin production is just senseless - that is the drug's intended "mechanism of action", so for Biomarin to file a NDA without any solid evidence of consistent dystrophin production is laughable, IMO.

  • tredleon tredleon Aug 19, 2015 5:56 PM Flag

    They don't rescind BTD/Priority Review/Fast Track based on trial results, just like they don't grant them based on probability of approval - it is based on the severity of the disease and the lack of effective treatments. You're as clueless as they come.

  • tredleon tredleon Aug 19, 2015 5:34 PM Flag

    simp - you moron - how long have you been on this board - the Etep dosing was at 30mg and 50mg!

  • Reply to

    ARC-520 FC - PPS$125-150 range!

    by jagan1961 Aug 17, 2015 4:36 PM
    tredleon tredleon Aug 18, 2015 9:19 AM Flag

    In what sense were my messages anti ARWR - I was as pleased as anyone to see that a reputable? analyst had put a huge target on the potential value of ARC-520, but when someone makes an illogical statement claiming that the value estimate by Goldman could be doubled simply by partnering it, I questioned it - how is that anti-ARWR?

  • Reply to

    ARC-520 FC - PPS$125-150 range!

    by jagan1961 Aug 17, 2015 4:36 PM
    tredleon tredleon Aug 18, 2015 9:01 AM Flag

    post - I am long ARWR - I just questioned his senseless post and he got bent out of shape. Apparently, there are a few people on this board that consider him knowledgeable?

  • Reply to

    ARC-520 FC - PPS$125-150 range!

    by jagan1961 Aug 17, 2015 4:36 PM
    tredleon tredleon Aug 18, 2015 6:56 AM Flag

    holden - With every new "lesson" you provide further evidence of how clueless you are. Let's assume Goldman is not as clueless as you and as part of their future projection, they took into account the dilution involved in getting ARC-520 to the finish line, including building the marketing infrastructure, etc.. Let's assume the purpose of their valuation was to show what the full potential value (not just US markets and not at some discounted value adjusted for execution risk) of a FC HBV drug would mean to ARWR's share price - the $150 number (even at a pre-dilution levels) represents approximately $10B in market cap. But without even knowing the assumptions that went into Goldman's valuation (it is likely they assumed a marketing deal outside the US), or specifying the scope of your fantasy "strong partnership deal, your "expertise" allows you to speculate that a partnership" would add another $10B of value? What a tool!

  • Reply to

    ARC-520 FC - PPS$125-150 range!

    by jagan1961 Aug 17, 2015 4:36 PM
    tredleon tredleon Aug 18, 2015 12:09 AM Flag

    kart - if holden really meant that, that is what he would have stated. If the Goldman value theoretically did not include global markets or an inefficient marketing infrastructure, he could have specified those things, but he didn't - he made his comment based purely on a partnership doubling the ESTIMATED FUTURE VALUE of ARC-520 to the ARWR shareholders and I called him on his stupidity. Now he is trying to play professor and it is making him look even more clueless.

  • Reply to

    ARC-520 FC - PPS$125-150 range!

    by jagan1961 Aug 17, 2015 4:36 PM
    tredleon tredleon Aug 17, 2015 10:13 PM Flag

    holden - What a moronic retort - I specifically challenge you on the premise of your post (that the Goldman value is a future value, not a DCF value taking into account the risk of clinical and commercial success) and you give me CAPITALIZED definition of a DCF valuation. Answer the question - is the $150 value you cited a CURRENT DCF value (i.e. based on todays facts and circumstances)? Secondly, I never stated ARWR shouldn't give up revenue/profit share in a partnership, I simply stated that giving a partner a share of an asset's future cash flows BY DEFINITION reduces the potential value of that asset to the company. If you are refuting that, you truly are a moron.

  • Reply to

    ARC-520 FC - PPS$125-150 range!

    by jagan1961 Aug 17, 2015 4:36 PM
    tredleon tredleon Aug 17, 2015 7:38 PM Flag

    You're playing mathematical masturbation and the result is an illogical mess. First off, Goldman's value is not a current "present value of future cash flows discounted for risk and time", it is by your own admission a future value - i.e. it assumes the risk of clinical and commercial success (including putting together a sales force) are taken out of the equation. Your declaration of a partnership resulting in the use of a "dramatically lower discount rate" is stating the same thing I did - i.e. you would see an earlier spike in the share price. This is meaningless in the context of Goldman's future $150 value, which assuredly does not include the sharing of future profits or payment of royalties. Face it - your statement that a partnership would double Goldman's future value estimate is senseless - accept it and move on!!!

  • Reply to

    ARC-520 FC - PPS$125-150 range!

    by jagan1961 Aug 17, 2015 4:36 PM
    tredleon tredleon Aug 17, 2015 6:35 PM Flag

    What you talkin' bout Willis? Let me re-state the issue as clearly as possible - Goldman supposedly placed a value on ARC-520 (assuming it is a FC) that resulted in a per share value of $150. The value of the drug is presumably based on the profit it would generate from future sales. In what universe would giving a partner a cut of the future profits (or royalty payments that would reduce future profits) result in a greater value of that drug to the company, unless the upfront payment and milestones are greater than offsetting profit-share/royalties? It really is a simple question of math - unless you believe a prospective partner is stupid enough to strike a deal where they pay the company more than they get back?

  • Reply to

    ARC-520 FC - PPS$125-150 range!

    by jagan1961 Aug 17, 2015 4:36 PM
    tredleon tredleon Aug 17, 2015 5:57 PM Flag

    How would a partnership double the value of the drug - most partnerships involve giving up a chunk of the profits for some upfront money and clinical development support. Assuming ARC-520 is a success, a partnership deal would provide an earlier spike in the share price, but it would reduce the potential long-term value, unless there is some new finance/math paradigm I am not familiar with?

  • Reply to

    excitement for eteplirsen

    by immediatereliefxxx Aug 17, 2015 9:26 AM
    tredleon tredleon Aug 17, 2015 5:47 PM Flag

    Has there been a "debate"? I have read numerous stories or twitter posts from parents of Etep boys convinced that Etep is providing true clinical benefit and now a story of parents flying coast-to-coast to get their boy in a trial. Has anyone seen any similar stories or postings from parents of Drisa boys - there certainly are many more of them out there than boys on Etep, but not for long.

  • tredleon tredleon Aug 17, 2015 1:56 PM Flag

    usingaliase - You sound as clueless as Tran - read the press releases and investor presentations, listen to the investor calls/presentations and decide for yourself if Tran's "issues" are valid. His two most prominent statements about the trials are clearly false - if you can't grasp that, then you should be on the sidelines permanently.

  • Reply to

    Canaccord webcast

    by ballchinian5 Aug 13, 2015 1:25 PM
    tredleon tredleon Aug 14, 2015 9:16 AM Flag

    I couldn't find the audio link for the Accelerate presentation, but their slide #26 confirms what the T2 CEO was saying - all the competitive products (except Abbot's Indica?) work off of the initial "screening", so if the initial screening does not identify an infection, then their AST is meaningless, right.

    The thing that I did not understand from the T2 CEO is that he hi-lites how much more sensitive T2's system is in identifying an infection, but then says their test will not replace or reduce traditional screening/cultures. If T2's system shows there is no infection (which is the case in 80% of high-risk patients tested), then why would the hospital go forward with a much-less sensitive test that would provide a less accurate result a day later?

  • tredleon tredleon Aug 13, 2015 1:44 PM Flag

    Can we assume that if there was a real possibility of generic approval prior to patent expiration that the company would have an obligation to disclose that fact? The CEO confirmed the patent portfolio behind Omidria at the most recent investor conference without disclosing this filing, so is that meaningful or deceitful?

  • Reply to

    omidria Q2 sales will be?

    by evlradr Aug 8, 2015 12:36 PM
    tredleon tredleon Aug 9, 2015 10:01 AM Flag

    Am I interpreting your post correctly - you are saying you will be disappointed with anything less than $100 million for the quarter? That's the mos delusional post I've seen in a while!

  • Reply to

    Baird Analyst and "Granularity"..

    by bionerd51 Aug 7, 2015 8:52 AM
    tredleon tredleon Aug 7, 2015 10:30 AM Flag

    nerd - unfortunately, you are probably right. When is the last time the SEC busted a company for violating the disclosure rules? If the analyst's firm has helped the company raise money, I'm sure it is expected that management will provide access and insights not afforded to the public.

  • Reply to

    Baird Analyst and "Granularity"..

    by bionerd51 Aug 7, 2015 8:52 AM
    tredleon tredleon Aug 7, 2015 9:49 AM Flag

    I can't imagine SRPT management would be stupid enough to "reveal" dystrophin or 6MWT scores - that would be a clear violation of the disclosure rules - but I could imagine a conversation like the following: Baird - "you are aggressively investing toward the launch of Etep, as well as the clinical trials for Exons 45 and 53, and it would seem imprudent to do so unless the 4th biopsy results and the re-reads of the original biopsy results were definitively positive"? SRPT management - "Yes. that would be imprudent of us".

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