for life .....................................................
The key here is that this drug does offer a benefit,Currently no other drug offers as much.While looking at the decline after 3 years of dosing it appears that it remains a major benefit when compairing natural history.It it also my findings that if you dose daily instead of weekly you would get a much much larger time frame of benefits .This drug is a patch or bridging over a bad exon .I am thinking that the drug is declining out of the body after dosing and causing the patch or bridging to become leaking after a few days therefor requiring a better patch or bridging ''daily dosing.
The only real reason Biomarin compared the two is because they have a much inferior drug and anyone that can read medial data knows this.''riding on the back of Sarepta's good drug for dmd''
one would be stupid,misled,evil or plain blind if they don't see that this drug is the best out there .
Roll these boys over to a twice a week dosing instead ofonce weekly.it is my theory that if you keep a constant of this drug in the body you maintain better use of the drug.it appears that this drug is expelled fast and therfore creating a seesaw effect on drug balance.
Is the best treatment option in the pipeline as of today..still a homerun drug.
you work on improving long term outcomes such as closer dosing time frames ,you must start somewhere and build upon science...
IS THIS DRUG IMPROVING THE QUALITY OF LIFE FOR DMD BOYS'''YES''
I THINK MANY INVESTORS ARE NOT VERY SMART BUT SELLING AND BUYING IS UP TO THEM..
over 3 years of dosing and the decline was far less than natural history
GILD is big enough to help another company like express scripts get started and compete .
is a very postive life extending outcome for this agressive disease.If you add any years of living life you have done a wonderful outcome.
We know the Sarepta dmd drug works better than any other ''even if long term it is only 25 percent effective ''we do know with curent short term it is about 55 percent effective''either way this drug will be a blockbuster drug.Once we get the sales and monies come to bare we can then start many other trials that will avail the same.
It is my opinion that exon skipping drugs should be dosed daily for having the best effects.
Isis Pharmaceuticals, Inc. (ISIS)-NasdaqGS Watchlist
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They don't have enough people for a class action suit for one and two these same law firms are doing the same to 275 other companies.they are trying class action because they could not ever win against a delaware corp.
•Male 7-16 years old
•Diagnosed with DMD, genotypically confirmed
•Stable dose of corticosteroids for at least 6 months
•Have intact right and left alternative upper muscle groups
•Mean 6MWT greater than 300m (primary analysis on 300 to 450 meters)
•Stable pulmonary and cardiac function: predicted FVC equal to or greater than 50% and LVEF of greater than 50%
•Previous treatment with drisapersen within the last 6 months
•Participation in any other DMD interventional clinical study within 12 weeks
•Major surgery within 3 months
•Presence of other clinically significant illness
•Major change in the physical therapy regime within 3 months