I wrote about this a year ago over on IV. Here's your search terms: LorVanse (Lorquess + Vyvanse) for smoking cessation, obesity, ADHD, and Binge Eating Disorder and while we're at it? Why not throw in depression...
And July 2017 is when PFE will come knocking, if not sooner for 371 - IF it's still available!
(371) "we have a full activator at physiological concentrations to that receptor" CB2
Jack Lief - President, Chief Executive Officer (Edited - this is for 371) ~September 2015
"...other pharmaceutical companies have looked at that receptor, have tested activators of that receptor, and have failed at reducing pain in humans. With our technology we interrogated why those compounds failed and we believe we understand now why those compounds failed.
"The reason they failed is when the receptor is over expressed in a cell line, the over expression results in thousands of times more receptor copies in that cell line than in normal physiology. That exaggerates the activity of that receptor in that cell line and compounds that (appear to be) full agonist activators are actually partial in that exaggerated system. We are able to knock down the number of copies of those receptors to physiological levels. We have a full activator at physiological concentrations at that receptor.
"We still have to test that hypothesis in humans. we know that in an animal model the compound looks as potent in some models as morphine, yet it's non-addictive and obviously doesn’t have the side effects of opioids [ph] associated to it. So to have a compound for chronic pain, things like endometriosis, chronic cystitis, osteoarthritis, all sorts of different kinds of pain - back pain... And it is not addictive? It could really be an important medical breakthrough in pain relief.
"We are getting 371 ready for Phase 2 in the first half of next year. We expect to complete the multi ascending dose for this compound around the end of this year, then get that compound ready for our Phase 2 and start that in the first half of next year. ...And of course we’ll have a read out in that area next year."