Hey Pal, I started with EPA Plus 500 in 2012 for 6 months 2 pills per day per the recommended dose of 1 gram. It help me with my mood swing but nothing more and cost me $45/month. Then switched to Vascepa at 4 gram per day and pay $9/month off label for the last two years. Now I am a true believer in Vascepa and been preaching to everyone who willing to listen how they can improve quality of their life with this drug witch is proven, at least to me, that the drug is ultra safe and effective. I don't worry about heart health nor heart attack anymore, not being pretentious, but taking Vascepa for so long gave me this sense of general well being. If you ask me to take 8 pills of Plus EPA 500, it would be too costly and risky without knowing what kind of latten side effect may manifest down the line; therefore, I wouldn't recommend this to anyone. I truly believe Vascepa will be widely available to general public once people understand what EPA does to every cell in body. Meanwhile, I will continue with my crusade to baby boomers to take Vascepa to get ahead in life - lately, I am hearing people say I look much younger than my age but what surprise me the most was that when my oldest daughter toll my wife who's 9 years younger than me that now I look younger than her and dad seem to age very slowly and that's all I need to hear from anybody, especially from you own family members. Good Luck.