Does the recent focus on secondary end points cause you any concern that even though still blinded vertex thinks fev improvement won't be good? Would they have any idea on whether fev is improving based on overall results?
Actually it is effective for nearly 20% of the cf population including 551 other gating and residual function mutations. It is just labelled currently for 551, but it will be expanded within a year for many more. And the combo will help nearly 50% of the cf population which will be approved by end of 2013.