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Yahoo! Inc. Message Board

whippersnapper65 68 posts  |  Last Activity: Nov 24, 2015 9:25 AM Member since: Jun 20, 2009
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  • Reply to

    The Liberal Media is in Mourning today

    by grey3840 Aug 26, 2015 12:04 PM
    whippersnapper65 whippersnapper65 Aug 26, 2015 4:35 PM Flag

    And homosexual and a mediocre employee. So quite a few things coalesced: he's black and had a chip on his shoulder to begin with because he'd been indoctrinated with "use the race card to get what you want." That got him so far, but when his employers began to realize he lacked talent and let him go, he claimed discrimination and filed formal complaints with the EEOC, but none of those complaints were found to have merit. Add to that the mental disorder of his sexual proclivity and the self-reinforced feelings of false victimhood compounded upon false victimhood turned this guy into a boiling kettle of hate against the world because he couldn't cope and thought that his gayness and his skin color would be tickets to easy street. Some people can't cope with the reality of their mediocrity. He blamed everyone but himself.

    BHO and the Democrat Party have encouraged and fomented this sort of entitlement thinking among interest groups.

  • I like his confidence and swagger.

    Sentiment: Hold

  • whippersnapper65 whippersnapper65 Aug 26, 2015 8:12 PM Flag

    May it become worth $3 million for him within four years.

    Sentiment: Hold

  • whippersnapper65 whippersnapper65 Aug 27, 2015 8:09 PM Flag

    And you know that Ellberger can't sell those shares until Celldex has an approved treatment. Of course, he can but he knows it would look bad for him to sell before Celldex has major positive news such as an approval. He's not buying these shares for a swing trade: he bought them for a long term investment until Celldex at least reaches commercialization.

    Sentiment: Hold

  • Reply to


    by montmain Sep 4, 2015 3:51 PM
    whippersnapper65 whippersnapper65 Sep 4, 2015 5:16 PM Flag

    A small study in children was conducted at Stanford University. The study was terminated in fall 2013; didn't lead to anything.


    A Phase I Study of Rindopepimut After Conventional Radiation in Children With Diffuse Intrinsic Pontine Gliomas

    This is a research study of patients with diffuse intrinsic pontine gliomas. We hope to learn about the safety and efficacy of treating pediatric diffuse intrinsic pontine glioma patients with the EGFRvIII peptide vaccine after conventional radiation.

    Stanford is not currently accepting new patients for this trial.
    You may want to check to see if other locations are recruiting.

    ◾Albert J. Wong, M.D.
    ◾Paul Graham Fisher, MD
    ◾Neyssa Marina
    ◾Michael S. B. Edwards, MD
    ◾Michael S. B. Edwards, MD
    ◾Michelle Monje
    ◾Gordon Li, MD

    ◾biological : Rindopepimut

    Phase: Phase 1


    Ages Eligible For Study:

    3 Years - 18 Years

    Sentiment: Hold

  • whippersnapper65 whippersnapper65 Sep 6, 2015 3:08 PM Flag

    That's hilarious, dbegley, You know, the Message Board Bonehead (mbb) has had no credibility since rays and I caught it deleting its old posts in a failed attempt to cover its lies about its posting history. Many of us have ignored it for a long time. Your evidence about its inconsistency is more proof that it is simply not worth paying any attention to.

  • whippersnapper65 whippersnapper65 Sep 7, 2015 6:50 PM Flag

    The preclinical data presented in the spring about combination varli and anti-PDL1 treatment showed that the synergy is virtually a cure that not only eliminates tumors but also halts tumor recurrence.

    Sentiment: Hold

  • whippersnapper65 whippersnapper65 Sep 7, 2015 8:32 PM Flag

    Celldex used the word "cured" in its press release dated April 20, 2015. I'll take Tibor Keler's opinion over yours any day.

    Key findings:

    The combination of varlilumab and anti-PD-L1 resulted in a significant improvement in survival over monotherapy in multiple preclinical tumor models, including a CT-26 colon model, an E.G7 thymoma model and a BCL1 disseminated lymphoma model. The properties of the BCL1 lymphoma model allowed for further analysis into the mechanism of synergy between varlilumab and anti-PD-L1. Importantly, mice cured by the combination therapy were shown to have developed protective immunity against the BCL1 tumor, demonstrating that a long lasting and potent memory response was generated during treatment. Additional key observations were made by analyzing the spleens (the primary site of tumor growth) following treatment. The major changes associated with the combination therapy included:
    • A greater reduction in tumor cells (as measured by % decrease in CD19+ cells)
    • Increased numbers of functional CD4+ and CD8+ T cells (as measured by IFNγ production)
    • An increase in the ratio of CD8+ T cells (effector T cells) to regulatory T cells or Tregs
    • A notable increase in myeloid cells, particularly neutrophils

    These changes at the site of tumor growth, particularly the balance between effector T cells and regulatory T cells, are consistent with an immune-mediated effect resulting in the destruction of tumor cells. The increase in myeloid cells merits further investigation into their role in the combination therapy effect. Other changes including increases in natural killer cells and decreased PD-1 expression on T cells were noted, but these were similar in magnitude to the monotherapy treatments.

    Sentiment: Hold

  • whippersnapper65 whippersnapper65 Sep 8, 2015 1:30 AM Flag

    Naysayers and anyone who hasn't already seen the graphs needs to look at the graphs on the poster that is linked to in the press release from April 20, 2015. I called attention to them soon after the PR was issued. The results of varli/anti-PDL1 combo therapy are jaw-droppingly amazing in eliminating tumors and providing immunity against tumor recurrence. If those results can be duplicated in humans, Celldex will skyrocket to over $200 per share overnight. If the results can be approximated, Celldex will still have a very valuable asset in varlilumab. The combo trials currently underway will go a long way toward providing evidence of how much promise varli holds, but we will have to wait a considerable amount of time for results.

    Sentiment: Hold

  • Not yet recruiting. Study just appeared on the clinicaltrials website. Scheduled to begin this month. Genentech (subsidiary of Roche) is listed as a trial collaborator.

    It's being tested in a host of indications:

    Carcinoma, Renal Cell
    Kidney Diseases
    Kidney Neoplasms
    Urogenital Neoplasms
    Urologic Diseases
    Urologic Neoplasms
    Neoplasms by Histologic Type
    Clear-cell Metastatic Renal Cell Carcinoma
    Triple Negative Breast Cancer
    Bladder Cancer
    Head and Neck Cancer
    Non-small Cell Lung Cancer

    Varlilumab is a fully human monoclonal antibody that binds to a molecule called CD27 found on certain immune cells and may act to promote anti-tumor effects.

    Atezolizumab is an engineered anti-PD-L1 antibody.

    This study will evaluate the safety, tolerability and efficacy of the anti-CD27 antibody varlilumab in combination with atezolizumab.

    Eligible patients that enroll in the dose escalation portion of the study will be assigned to one of three dose levels of varlilumab in combination with 1200 mg of atezolizumab. The first phase of the study will enroll up to 18 patients and test the safety profile of the combination of varlilumab and atezolizumab in patients with various tumor types and determine which dose of varlilumab will be studied in Phase ll of the study which will enroll only patients with RCC.

    During Phase ll, up to 37 patients will be enrolled and receive the recommended Phase ll dose of varlilumab in combination with atezolizumab 1200 mg.

    All patients enrolled in the study will be closely monitored to determine if there is a response to the treatment as well as for any side effects that may occur.

    Sentiment: Hold

  • Reply to

    If you can not afford to wait

    by grey3840 Sep 10, 2015 1:34 PM
    whippersnapper65 whippersnapper65 Sep 10, 2015 6:17 PM Flag

    What keeps the Message Board Bonehead here is his pathological need for attention that his parents never gave him. I wish MBB would ignore me instead of red-thumbing my posts. I've ignored him for about two years now and have never replied to nor unignored his greyed-out messages, yet I notice that he still replies to my posts and gives me red thumbs. His ticker symbol is LOSR.

  • Reply to

    New Varli Trial

    by fludyspnea Sep 17, 2015 12:37 AM
    whippersnapper65 whippersnapper65 Sep 17, 2015 1:06 AM Flag

    Yes, good to see. I posted about this trial on September 9 and received 4 red thumbs. Let's see how many red thumbs you get for this positive, factual post. Shorts are so stupid. How can you red thumb straight facts and consider yourself to be intelligent or reasonable?

    Sentiment: Hold

  • Reply to

    New Varli Trial

    by fludyspnea Sep 17, 2015 12:37 AM
    whippersnapper65 whippersnapper65 Sep 17, 2015 9:41 PM Flag

    Yes, I agree that the increasing number of Varli combo trials is a good sign. The unreleased data in the trials in progress must be auspicious, and management wants to have as much evidence as possible that Varli will bolster the efficacy of just about every other cancer treatment out there. When investors get wind of that, the share price will be in triple digits as a base.

    Sentiment: Hold

  • Reply to

    Has this trial been press released?

    by jrwhokiefan Sep 20, 2015 3:14 PM
    whippersnapper65 whippersnapper65 Sep 20, 2015 4:59 PM Flag

    No. I expect Celldex will announce the trial when it begins to recruit patients. The listing on the clinicaltrials website indicates that the trial status is "not yet recruiting".

    Sentiment: Hold

  • Reply to

    Price Action

    by maximus06906 Sep 25, 2015 2:58 PM
    whippersnapper65 whippersnapper65 Sep 25, 2015 3:06 PM Flag

    It has been silly ever since it dropped below $24. Now it is Alice in Wonderland, nonsensically absurd.

    Sentiment: Hold

  • whippersnapper65 whippersnapper65 Sep 25, 2015 3:13 PM Flag

    Maybe Larry Ellberger will buy another 5,000 shares.

    Sentiment: Hold

  • whippersnapper65 whippersnapper65 Sep 28, 2015 11:02 AM Flag

    I started ignoring zorbs a long time ago when it became clear that he's a whiney weasel who gets his investing ideas from stock tweets and attempts to influence stock prices with his own tweets, and he would desperately beg people to post reassuring information or opinions about stocks he owned. Check market pulse on yahoo to see what I mean; he's all over it. Zorbs lost money buying high and selling low because he doesn't have the patience nor the savvy required for biotech investing. If he's claiming he wants to buy back in lower, he's just putting a lame spin on losing money in order to avoid the conclusion that he's a terrible investor.

    Sentiment: Hold

  • whippersnapper65 by whippersnapper65 Sep 28, 2015 2:47 PM Flag

    Celldex traded at its highest valuation in its history, over three times the current valuation.

    Two years ago the company was in poorer financial and fundamental shape than it is today.

    Two years in the future Rintega and Glemba will have been commercialized and the world will have a good idea of what Varli's potential is.

    Longs will look back on today's share price the way you remember a bad hangover from years past: no harm done and a full recovery since then, but it was a very unpleasant experience when it occurred.

    Sentiment: Hold

  • Reply to

    This week in 2013

    by whippersnapper65 Sep 28, 2015 2:47 PM
    whippersnapper65 whippersnapper65 Sep 28, 2015 3:02 PM Flag

    And there's the red thumb from the message board bonehead, just like clockwork.

  • Reply to

    Bankrupt or Being Played?

    by hepididlewee Sep 28, 2015 2:07 PM
    whippersnapper65 whippersnapper65 Sep 28, 2015 7:09 PM Flag

    ignore the message board bonehead and you don't have to read any more of that troll's idiocy

33.16+0.20(+0.61%)Nov 25 4:00 PMEST