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Celldex Therapeutics, Inc. Message Board

whippersnapper65 138 posts  |  Last Activity: Jun 24, 2016 11:41 AM Member since: Jun 20, 2009
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  • Reply to

    Good For The British People

    by j20tower20 Jun 24, 2016 10:31 AM
    whippersnapper65 whippersnapper65 Jun 24, 2016 11:41 AM Flag

    I would hope that if the Supreme Court gets stacked with leftists who commit jurisprudential malfeasance by rendering decisions that are routinely unmoored to Constitutional principles and the Constitution itself as written and originally intended, there will be a convention of states as per Article Five to reassert the right of the people not to live under the tyranny of a federal government. That would be America's last hope.

  • Reply to

    Good For The British People

    by j20tower20 Jun 24, 2016 10:31 AM
    whippersnapper65 whippersnapper65 Jun 24, 2016 10:59 AM Flag

    Polling data show that older people, who remember what Britain was like (meaning better) when it was independent, carried the "leave" vote over the top. Foolish and ignorant millennials who don't know how socialism ruins a nation, economy and society, voted overwhelmingly to stay in the union.

    Millennials and unassimilated immigrants will be the ruination of America, as they have begun to ruin Britain. It's already happening. That's been the Democrat plan for at least a decade. There may be hope for Britain, but the jury's still out about America.

  • whippersnapper65 whippersnapper65 Jun 21, 2016 5:18 PM Flag

    re:"The pivotal TNBC trial is open label so CLDX is aware of results as the trial progresses- "

    I asked IR about this: whether management has knowledge of open-label METRIC patient responses as the trial progresses. I was told that management is blind to the METRIC data.

    I'm not sure how that can be since the trial is open-label, but I didn't ask for clarification since my original question had been extremely clear.

    Sentiment: Strong Buy

  • whippersnapper65 whippersnapper65 Jun 21, 2016 2:17 AM Flag

    Is it reasonable to conclude that changing the primary outcome wording to specify the possibility of a complete response being observed means that some complete responses, among other responses, have been observed and the investigators are finding it necessary to distinguish types of disease control so that a more precise description of Glemba's efficacy can be provided at the study's end?

    Surely you don't begin an investigational study with a protocol that calls for measuring complete response rates out of fear that there might be none. I think adding the new wording and shortening the length of time for the study are both very positive indications.

    Let's hope that Glemba's targeting of gpNMB is proving effective and will be comparably effective in the METRIC breast cancer study and in the melanoma study.

    Smart bombs targeted at cancer cells: wave of the future.

    Sentiment: Strong Buy

  • Reply to

    MBB On Ignore Along with A Few Other

    by j20tower20 Jun 20, 2016 11:12 AM
    whippersnapper65 whippersnapper65 Jun 20, 2016 12:42 PM Flag

    I ignored those sheetheads a long, long time ago.

  • Reply to

    QA admin position

    by btchinvstr Jun 17, 2016 5:30 PM
    whippersnapper65 whippersnapper65 Jun 17, 2016 8:28 PM Flag

    Yes, I would like to know what "pre-BLA approval" referred to in the job description.

    A phase 2 glemba trial in advanced melanoma patients is scheduled for primary data collection next month, according to clinical trials gov.

    I would also like to know why management is now seeking a "top executive" SVP of global regulatory affairs. Unless there are indications that a treatment will be approvable in less than a year, it seems premature to be seeking that sort of candidate.

    Sentiment: Strong Buy

  • Reply to

    Merck's Keytruda Results this Morning

    by maximus06906 Jun 16, 2016 2:25 PM
    whippersnapper65 whippersnapper65 Jun 16, 2016 2:39 PM Flag

    No, but there is a combination trial with Roche's Atezolizumab, which targets PD-L1, like Keytruda.

    Sentiment: Strong Buy

  • Reply to

    Merck's Keytruda Results this Morning

    by maximus06906 Jun 16, 2016 2:25 PM
    whippersnapper65 whippersnapper65 Jun 16, 2016 2:35 PM Flag

    Well, one huge reason to invest in Celldex is for Varli, which might improve the efficacy of Keytruda, Opdivo and other checkpoint inhibitors. Celldex's approach is combination immunotherapy, as its executives wisely foresaw that the future of cancer treatment would be in combination treatments.

    Sentiment: Strong Buy

  • Reply to

    MBB

    by francogarabaldi Jun 15, 2016 8:15 PM
    whippersnapper65 whippersnapper65 Jun 15, 2016 8:51 PM Flag

    Most of the meaningful and valuable advances, discoveries and creations in science, philosophy, government, music, art, literature, and technology have come from the West. The idiotic, multicultural push to assert that all cultures are equal in value is a push to void the concept of excellence in beauty, goodness and truth: in essence to eliminate any standards against which the merits of anything else is judged, unless it happens to have originated with or been done by a dead, white, european, heterosexual, Christian male; in that case, the Left rules it to be meritless by default because of the Left's foolish and destructive racism against whites.

    With all of the looney hoopla in the Left now about "cultural appropriation", I suggest that no non-Western person be allowed to attend university because the university was invented by whites and is part of Western culture; if you're not white or European, you have no business studying at university. That's cultural appropriation of white, European culture.

    If white college students can't wear sombreros while eating tacos because that's deemed by hispanics to be racist, cultural appropriation, if a white girl can't wear her hair in corn rows because that's deemed by blacks to be racist, cultural appropriation, then what's sauce for the goose is sauce for the gander: no non-Western person should be permitted to enjoy, use, partake in anything that is part of Western heritage.

    See how stupid Leftism is? All I did was follow a Leftist premise to its logical conclusion, and it resulted in an absurdity. The problem is that not many Leftists think about the implications of their foolish beliefs. For once they started doing that, it would mark the beginning of their journey to becoming a conservative.

  • Reply to

    More from the FBI...

    by mybestbehavior Jun 15, 2016 12:20 PM
    whippersnapper65 whippersnapper65 Jun 15, 2016 8:10 PM Flag

    Ray, regarding leaving the judgment to God: ultimately the fate of every person's soul is in the hands of God alone. None of us can judge a person's state of soul nor their eternal fate, whether salvation or damnation.

    On earth Christians have a duty to proclaim Christ and his kingdom through the Church, which carries a corresponding duty to work for that kingdom's greater realization through preaching, prayer, worship and corporal and spiritual works of mercy.

    "Stop judging by appearances, but judge justly!" (John 7:24)

    "My brothers, if anyone among you should stray from the truth and someone bring him back, he should know that whoever brings back a sinner from the error of his way will save his soul from death and cover a multitude of sins." (James 5:19-20)

    "You are the salt of the earth. But if salt loses its taste, with what can it be seasoned? It is no longer good for anything but to be thrown out and trampled underfoot. You are the light of the world. A city set on a mountain cannot be hidden. Nor do they light a lamp and then put it under a bushel basket; it is set on a lampstand, where it gives light to all in the house. Just so, your light must shine before others, that they may see your good deeds and glorify your heavenly Father." (Matthew 5:13-16)

    So Christians have a duty to be salt, light and leaven in the world, that more of the world may be brought to God's kingdom.

    Those Christians who have a responsibility to preserve the good of society must act in ways that promote the common good, peace, liberty, virtue and prosperity. As a practical matter, not everything that Christians consider sinful can or even ought to be made criminal. Prudential judgment would determine the correct set of laws and their just application, with the first priority of the civil authority being the preservation of the good of social stability, the second priority being to foster virtuous behavior among citizens. In all laws, no person's natural rights may be violated.

  • Reply to

    More from the FBI...

    by mybestbehavior Jun 15, 2016 12:20 PM
    whippersnapper65 whippersnapper65 Jun 15, 2016 5:48 PM Flag

    Ray, there is a difference between casting stones and judging sins as sins. Jesus didn't advocate avoiding judgments about sins: he castigated those who would judge the sinful behavior of others without consideration of their own faults; hence the passage about seeing the splinter in your brother's eye while ignoring the wooden beam in your own. Jesus did not advocate tolerance of sin; quite the contrary: he advocated repentance, turning away from sin into the Father's merciful arms. You cannot call people to repentance without judging the sin as sin.

    The Left is attempting to blame Christians, blame the Right, blame guns, blame bathroom laws, blame conservative opposition to same-sex marriage, blame anything and everything except Islamic influence. When Christians refuse to bake a cake for a SSM, it is Christian religious hate; but when a Muslim murders 49 people in a gay club it is the fault of guns. Not buying it, nor is anyone else who can still think straight in this country.

    it is not hypocritical for Christian conservatives to oppose SSM and to mourn the lives lost in the massacre, as people like Anderson Cooper are now stating. SSM is immoral and unnatural; no wise or sensible civilization would approve it, normalize it or legalize it. Homosexual behavior is unnatural and immoral. But opposing SSM and homosexual behavior doesn't prevent someone from mourning the loss of fellow Americans' lives in a massacre, even if those Americans disagreed with them about SSM. Anderson Cooper is not being intellectually honest; he's trying to win media debate points.

    Democrats are shamelessly using the massacre as an opportunity to score debate points and press for unneeded and unhelpful restrictions on the Second Amendment. They are casting blame wherever it will advance their Leftist objectives; everywhere but where it belongs: the influence of Muslim attitudes that are hostile to and incompatible with American culture.

  • Reply to

    Ever hear of "Man Love Thursday" cyoung?

    by investwith6s Jun 14, 2016 5:11 PM
    whippersnapper65 whippersnapper65 Jun 14, 2016 6:32 PM Flag

    Islam is full of homosexuals. Their distorted religion drives them to it: they can't look at women but they can look at boys. They can't be alone with a strange woman, but they can be with boys. Boys are used for pleasure.

    Multiculturalism is nonsense. Islam produces an inferior, evil culture. Middle Eastern, Islamic cultures are inferior cultures. Importing immigrants to our country when they have cultural attitudes incompatible with ours and our laws is insane.

    Trump is right: America needs to halt Muslim immigration because of the cultural incompatibility between Islam and the Western ideals upon which America was founded. Furthermore, we should halt all immigration temporarily until we get a handle on just who is here, until we can determine who is legal, and until we can assimilate those who are here legally and intend to remain. Unfettered immigration without assimilation is going to produce a balkanized American population, as is happening in parts of California, which are now nearly indistinguishable from Mexico.

  • whippersnapper65 whippersnapper65 Jun 14, 2016 3:56 PM Flag

    His co-workers reported him for suspicious behavior but the FBI didn't pursue it much because the agency thought his co-workers were being racist and anti-Muslim. Disney apparently reported him and his wife to the FBI for casing the amusement park in April. Why wasn't he being shadowed by law enforcement 24 hours a day? Answer: because political correctness prevents effective law enforcement against minorities. Political correctness, leftism, is going to corrode American society. Look around and open your eyes, Democrats! You have made this mess! Time to make America great again.

  • whippersnapper65 whippersnapper65 Jun 14, 2016 11:55 AM Flag

    greenunderwear wrote: "I think I do know I quoted the contents of filing and its date."

    Since you insist on being a numbskull, let me explicitly identify your errors for you:

    1) "Act 1V,completed enrolling Dec 2014, DSMB recommended continuation in Feb 2015,"

    No, the DSMB recommended continuation in June 2015.

    2) " the second interim results were due late 2015/early 2016, looks to me as though this was pulled on second interim results"

    Wow, captain obvious. You are bright.

    3) "As far as I can make out they were looking for .progression free survival after six months."

    No, ACT IV's primary endpoint was overall survival.

    4) "Asco 2015 they presented phase 2 results. 8k filed 20150224 with slide "

    That data was from the ReACT trial, not the ACT IV trial.

    As I stated, you don't know what you're talking about, and you don't know the difference between ReACT and ACT IV. Do some homework about the company before you post more ignorance here. You don't know what you're talking about. All you do is copy and paste without comprehension. You find things but don't understand their relevance or irrelevance.

    Sentiment: Strong Buy

  • whippersnapper65 whippersnapper65 Jun 13, 2016 9:58 PM Flag

    You don't know what you're talking about, greenunderwear. Before posting another message to this board you need to do some homework -- at a minimum -- about the difference between the ReACT and ACT IV trials. So much of what you wrote betrays ignorance about Rintega's timeline and events. You don't know anything about this company, which is probably why you post so much TA nonsense. You don't know what you've invested in, if you've bought any CLDX shares at all.

    Sentiment: Strong Buy

  • whippersnapper65 whippersnapper65 Jun 13, 2016 5:41 PM Flag

    Celldex doesn't have the time for another study, either. ACT IV began in 2011 and it took until 2016 and a cost of over $200 million for it to conclude as a failure. A new Rintega study in GBM, even if it were to start in 2017 probably wouldn't conclude until 2022 and would probably cost over $300 million. Sorry, but either Celldex gets something out of Rintega with the data in hand or it should shelve the treatment. Too bad for all those with EGFRviii+ GBM. Rintega works, but something went awry in ACT IV's control arm, and patients will be denied an effective treatment as a consequence.

    Well before 2022 Celldex had better have both Glemba and Varli commercialized and generating revenues of over $10 billion per year. Maybe at that time the company will have the luxury of considering a lengthy and expensive new Rintega trial.

    Sentiment: Strong Buy

  • whippersnapper65 whippersnapper65 Jun 13, 2016 5:10 PM Flag

    I tend to agree, although to be fair to long_vrts2 his post concerns Rindo+Avastin (the ReACT trial) rather than Rindo plus temozolomide (the ACT IV trial). Even so, Rindo is unapprovable without additional Rindo+Avastin data (another trial, which isn't going to happen soon) or an explanation for the anomalous control arm in ACT IV that would lead to a revision of the control arm's OS and make Rintega's OS compare favorably to the revised control's OS with statistical significance.

    We know Rintega works. Too bad something went wrong in ACT IV to skew the control arm.

    Sentiment: Strong Buy

  • Reply to

    Pathetic

    by invest83838 Jun 13, 2016 6:30 AM
    whippersnapper65 whippersnapper65 Jun 13, 2016 12:30 PM Flag

    Fully agree with you, 83838.

    I would add that on this board the frequency with which someone posts is inversely exponentially proportional to the value of his posts, whether about CLDX or politics.

    I must have 95% of the posters here on ignore, and all of the frequent posters are on ignore.

    Sentiment: Strong Buy

  • whippersnapper65 by whippersnapper65 Jun 11, 2016 2:28 PM Flag

    My Saturday morning view: all ignored and hidden.
    %#$& all you childish losers!

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  • Reply to

    The Next President

    by invest83838 Jun 10, 2016 7:17 AM
    whippersnapper65 whippersnapper65 Jun 10, 2016 10:21 AM Flag

    Carter made Iran the power it is today by failing to support the Shah. The modern problems with radical Islam have their roots in the Iranian revolution against the Shah.

CLDX
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