wiseman, today its price crashed so much, do you still believe CLLS will anounce some big surprised news to the public during ASH? DO you listen to today Conf hosted by CLLC, PFE and Servier jointly attending to? If there were hide some big news for now, generally there always some leaking in some channel. Right now I am doubt of everything I am facing now in CLLC. Where did you get some driving force in CLLS for now?