Fri, Feb 27, 2015, 8:08 PM EST - U.S. Markets closed

Recent

% | $
Quotes you view appear here for quick access.

Arrowhead Research Corp. Message Board

wyattkap 374 posts  |  Last Activity: 6 hours ago Member since: Jun 10, 1998
SortNewest  |  Oldest  |  Highest Rated Expand all messages
  • All good logic Dig. I think we all need to realize that with many thousands of drugs approved by the FDA, rarely does one drug cure EVERYONE. Individuals react different to every drug. So, with that said, it's only logical that we as a company expand our drug delivery base to include many different ways to reach the FC goal for more people. Some may reach FC via just ARC-520 all alone. Others will need NUC's, others many need something else to help boost the Immune system to put their specific HepB fire out. THE GREAT part is we are the FOUNDATION with our DELIVERY TRAIN to open all those opportunities that do become available over time to help anyone and everyone in need. EVEN GILD is trying to improve on their HepC products to keep and improve their market-share! Have a great weekend everyone, another great week of learning and marking off baby step progress to help us all become better investors. Realizing our involved ON-GOING Multi-Dosing testings has proved good information that I feel is driving managements high show of confidence into more aggressive Single-Dual & Parallel Ph2B trials in both the US and abroad. AS USUAL-they know more than we understand and that is good thing that we will soon learn about when the time is right.

    Sentiment: Strong Buy

  • wyattkap wyattkap 21 hours ago Flag

    If you listen to the most recent interview with Givens, HE said they would be doing Liver Biopsies for best data results.

    Sentiment: Strong Buy

  • Reply to

    1mg multi-dosing trials should be quickly approved

    by hparch Feb 26, 2015 10:04 AM
    wyattkap wyattkap Feb 26, 2015 1:30 PM Flag

    So glad you now see what I been seeing that the company has given us information on. When I saw their very aggressive PH2B approach wanting to Parallel a 2mg with the 4mg and the 4mg single dose information was not PUBLIC YET??? I knew they know MUCH more to make such a decision and that could only be from the Non-Clinical Multi-Dose Testing they have on-going that has already shown them: KD at single dose 3mg and 4mh levels, enhanced KD via Step-Down due to long drug durations so 1Log is ACHIEVED, and NO TOXIC Issues to date???? The Non-Clinical's in my opinion are continuing because we just may see a FC announced in a Chimp or two as enough time has gone by since last dose given. Wouldn't that be a SHOE DROPPER this Spring or early Summer!

    This is where I feel most of the conversation needs to be focused. Multi-Dosing is the #1 PATH we all now understand that will be taken to reach FC goals and this is major information that can come at any time.!

    Sentiment: Strong Buy

  • Reply to

    1mg multi-dosing trials should be quickly approved

    by hparch Feb 26, 2015 10:04 AM
    wyattkap wyattkap Feb 26, 2015 12:49 PM Flag

    No problem END: The other CLEAR disclosure of THE ARC-520 Multi-Dosing is in the Company FDA Response Reslease on Jan 12th and I QUOTE: "The FDA also requested a final study report from an ongoing multiple-dose non-clinical study, which has shown ARC-520 to be well tolerated with no evidence of end organ toxicity to date." The FDA committed to provide the Company with a letter detailing its thoughts and requests within 30 days". (END QUOTE) *** NOW READ THAT REAL CLOSE EVERYONE! Multi-Dosing and NO TOXIC ISSUES, yet we still have folks WORRIED over it??????? WE HAVE BEEN INFORMED Directly from the company and the FDA WANTS EVEN MORE FROM THIS ON-Going Study!!!! 1 + 1 = 2 FOLKS Listen to the COMPANY and No One ELSE!

    THIS IS THE BIG SHOE TO DROP for the Shorty Boys & Girls! ALMOST no one saw it and NO ONE TALKING ABOUT IT, but ME! ON-Going Multi-Dose TESTING in BOTH Arc-AAT & Arc-520 is giving our team TONS OF INFORMATION and at any time this WILL be TALKED ABOUT. As Bruce Givens SAID "We have not talked about it yet and he called it INTERESTING Information!!!" YEA-It is so INTERESTING they tired to push a very aggressive Ph2B Dual Parallel Tests towards the FDA on the 1st go with them.

    Sentiment: Strong Buy

  • wyattkap wyattkap Feb 26, 2015 12:25 PM Flag

    Yea-you can tell that to the people and family members that are seeing 400 MILLION Chronic Cases suffer and about 1 MILLION die each year. REMEMBER THIS POST EVERYONE: Zoom just showed EVERYONE how well informed he/she is about HepB and the lack of DD applied. IF you pay attention to the details with the ARWR bashers, you find this is quite common among them ALL!

    Sentiment: Strong Buy

  • Reply to

    1mg multi-dosing trials should be quickly approved

    by hparch Feb 26, 2015 10:04 AM
    wyattkap wyattkap Feb 26, 2015 12:18 PM Flag

    AAT release on 2/23: In primate studies, a 90% reduction of AAT in serum was observed after a single injection, which persisted for over ten weeks with greater than 80 percent knockdown observed at the six-week time point. ^***Multi-dose studies in primates showed a sustained reduction of AAT with once every six weeks dosing.**** The goal of treatment with ARC-AAT is to reduce the hepatic production of Z-ATT, thereby preventing further accumulation of Z-AAT in the liver and potentially reversing pre-existing liver injury and fibrosis. THEY CLEARLY STATED ONCE EVERY 6 WEEKS DOSING for SUSTAINED REDUCTION!!!

    ARC-520 via the FDA Requests for more information on the Multi-Dosing Non-Clinicals. Further mentioned in the Givens Interview at about the 6 minute mark.

    Sentiment: Strong Buy

  • Reply to

    1mg multi-dosing trials should be quickly approved

    by hparch Feb 26, 2015 10:04 AM
    wyattkap wyattkap Feb 26, 2015 11:08 AM Flag

    Yes, I also agree and in the other jurisdictions is where the current Non-Clinical Multi-Dosing tests are being performed and I'm sure they are at the higher 3mg and 4mg levels to prove up step-down results, show 1Log KD is reached, and eliminate the safety concerns. This kind of information could come out ANY time, and that would be a FIRESTORM to anyone not long this stock.

    We now understand that we have been MULTI-DOSING in BOTH ARC-AAT & ARC-520 for some time now and with that knowledge, our company has chosen to get SUPER AGREESIVE with the Ph2B trials. Tells me we are hitting our KD Goals, Toxic issues are under control, and now we are looking to expand a Combo Plan to better aid & secure a FC that should produce results with less doses and in less time! The cost of a FC can be the same no matter if its 3 or 6 doses! A FC has certain value and the fewer the doses, the higher the profit margin, the more convenient to the patients AND with our NEW DPC coming down the road it will get even better, more convenient and more profitable in 2017-18!

    Sentiment: Strong Buy

  • Reply to

    Shorts worried about PCH being lifted

    by harcerz4 Feb 25, 2015 6:11 PM
    wyattkap wyattkap Feb 26, 2015 6:47 AM Flag

    I understand it to be when one done the other starts. That is why they are going overseas to do the DUAL & PARRALLEL Multi-Dose Testing discussed in the last interview. They want the understanding of the safety protocols with the FDA so they can duplicate in the overseas tests. FDA is the FDA for US approval, so I expect things to move much faster overseas, but shore up the data for possible earlier FDA approval. We start getting FC's and start saving lives and the ballgame swings our way as no severe toxic issue or other side effects come about.

    Sentiment: Strong Buy

  • Reply to

    Shorts worried about PCH being lifted

    by harcerz4 Feb 25, 2015 6:11 PM
    wyattkap wyattkap Feb 25, 2015 9:46 PM Flag

    Yes-I don't think PCH as much to do with it. We all know the 1mg Ph2B trial is a go soon, but I feel the real worry for a short is:
    A) the great information learned about the Arc-AAT Ph1Trial that is now dosing patients
    B) confirmed we do have a NON-Clinical Multi-Dose test running that could dump massive information at any time.
    C) Constant stream of NEWS RELEASES of tests is NOT going to be a Shorts Best Friend for the entire year ahead of us!

    Sentiment: Strong Buy

  • Reply to

    COUNT 15 MLN shares before you Sell!

    by jagan1961 Feb 25, 2015 1:39 PM
    wyattkap wyattkap Feb 25, 2015 2:06 PM Flag

    Sometimes the TRUTH HURTS and I'd say your comments HP are right on.

    Sentiment: Strong Buy

  • A) GO back and watch the June 2014 Video Presentation by Dr. A at the Master Investor Program. (Youtube it) At the 9:40 time, Dr. A goes into the AMAZING Data collected on the VERY ILL Female Chimp. ie 90%+ Key Viral's Dropped, ALT Showing Immune System is awakened etc, AND DR. A said "FEEL they would need 3 to 6 months with about ONE DOSE/Month to give a FC a chance". ***KEY POINT: DR. A wanted to keep working with that chimp in the United States to see if a FC was possible.***

    B) A few weeks ago we learn via the FDA response to the PH2B protocol negotiations that the FDA wants more information on our SUPRISING NON-Clinical MULTI-DOSING Animal Testing Status. Re-confirmed yesterday via the interview with Dr. G. Yesterday we hear: "About the EXCITING Non-Clinical Animal Study going on that they have not talked about YET!!!"

    C) Put both A & B together and I'm seeing Dr. A and team working with other Chimps overseas in a friendlier environment and IMO are working towards a FC announcement LONG before our Human Clinical Tests are completed.

    D) The Non-Clinical Multi-Dosing Program: I see them seeing accurate 3mg and 4mg single dose numbers, AND Multi-Dose STEP-DOWN KD numbers, with numerous doses applied to further show them Toxic answers. I believe this played a role in why we were so AGRESSIVE with DUAL & Parallel Tests in our 1st push to set Protocol with the FDA for Ph2B. NOW the DUAL & Parallel will be done Overseas and the SLOW one drug level at a time will be done in the US that will further eliminate future Safety concerns via other drug candidates. I see us getting approved in the foreign markets before the US.

    THIS is the BIG BEAR TRAP that will snap shut one day VERY SOON! IMO

    Sentiment: Strong Buy

  • wyattkap wyattkap Feb 25, 2015 12:16 PM Flag

    BINGO PT!

    Sentiment: Strong Buy

  • Reply to

    Reality once again proves pumpers wrong!

    by carrix_fool Feb 24, 2015 5:52 PM
    wyattkap wyattkap Feb 25, 2015 11:18 AM Flag

    I agree with you HP. No one can convince me they don't have good clear understanding of single dose 3mg and 4mg KD at this time. I feel they can see the blinded data as they SAID way back in the 1mg and 2mg discussion PRIOR to the unblinding of that data, "The blinded data results lead them to understand who was who in the trials (educated guess until confirmed when blinding removed)." This time around, they just will not talk about 3mg or 4mg as per the elements that exist today with warping the true meaning of the results.

    ****PLUS, DON'T ANYONE FORGET!!! They have been doing NON-Clinical Multi-Dosing for some time over-seas. YES-it is most likely via a Chimp Model, but the very similar results already seen (EXCEPT for LONGER DRUG DURATION IN HUMANS) FURTHER educates them on:
    1) Single Dose KD at all levels tested that I'm sure includes 3mg and 4mg,
    2) Multi-Dose KD Step Down Doses recorded, thus great potential seeing a 1Log KD achieved.
    3) Any possible TOXIC ISSUES via the Multi-Dosing levels to date! -AND-
    4) They are seeing this Non-Clinical progress building of information EVERY DAY and it has shown itself to be important enough that the FDA wanted an UPDATE and Final Report for the Ph2B protocol!!!
    5) YOU DON'T submit a Ph2B trial protocol asking for 4mg Multi-Dosing Regime WITHOUT a GOOD TESTED UNDERSTANDING of the Individual Dose KD results????

    Sentiment: Strong Buy

  • wyattkap wyattkap Feb 25, 2015 9:57 AM Flag

    I think most agree with your comments. I do. The over-used-outhouse nasty smell here is the over-the-top short positions here at under $10/share. With two candidates we have RAPIDLY moving forward and each on their own support a share price well above where we trade today. Add in about $3/share in cash and the REAL ADVANTAGE here in ARWR is the DPC Delivery Platform and that is why I am buying as much as I can and will pound the table to my friends. This stock has NO business trading down at these levels NOR a short position of this size. There is evil working here BECAUSE it will show so much future value.

    Sentiment: Strong Buy

  • wyattkap wyattkap Feb 25, 2015 9:40 AM Flag

    I also saw that as the best information given in the interview. Duel Parallel Multi-Dose Tests starting in Q2 in Europe/Asia. On-going Non-Clinical Multi-Dose Animal Testing still to be talked about. My money is on several on-going chimp studies that are offering KD Step-Down and Non-Toxic data that has given management the confidence to move this aggressive regime forward.

    I also agree with END that the Combo Regime will be the FC ticket puncher. It logically should offer much faster results to secure a FC.

    Sentiment: Strong Buy

  • Reply to

    Webcast recording is available

    by mudbug021 Feb 24, 2015 6:26 PM
    wyattkap wyattkap Feb 24, 2015 6:46 PM Flag

    I use Chrome and it worked just fine. Re-boot and try again. It will work for you and enjoy benny!

    Sentiment: Strong Buy

  • Reply to

    Reality once again proves pumpers wrong!

    by carrix_fool Feb 24, 2015 5:52 PM
    wyattkap wyattkap Feb 24, 2015 6:36 PM Flag

    C-FOOL: SO PREDICTABLE. NOTHING TO SAY so Here you go again manipulation of the ideas presented by many and the company. YOU'RE back to 3/4mg will not hit 1log. C-FOOL: How many times do you need to be told that will happen via MULTI-Dosing at these levels???????????? Does it matter if it takes (2) 3mg or 4mg doses to reach 1Log+???? NOT HARDLY! BUT even with that said, the 3mg and 4mg single dose information is still not ready to be released. STILL BINDED due to LONG DRUG DURATION out to 85 DAYS. Keep your lies pumping and ignore the facts presented by the company. Keep pushing your wet-noddle up hill!

    Sentiment: Strong Buy

  • Reply to

    Good interview

    by hparch Feb 24, 2015 5:55 PM
    wyattkap wyattkap Feb 24, 2015 6:28 PM Flag

    Just as I also expected and also very happy with what we heard. (My audio was GREAT) YES-we all want new and more information, but their plan is solid and clearly on track. I was glad to hear at the 5:55 minute level he mentioned our very interesting non-clinical animal testing that is on-going "THAT THEY HAVE NOT TALKED ABOUT" that the FDA wanted updates on. FOLKS, I think this is where they are clearly seeing via Multi-Dosing the true Step-Down KD advantages AND NO Toxic issues via multi-dosing. Thus the aggressive 1st run at the FDA for Ph2B attempted!

    I'm also VERY Glad they will continue their planned Dual & Parallel Multi-Dose testing (2mg & 4mg) in Europe & Asia and it sounded like that also could start in Q2.

    BEST PART??? ZERO BAD NEWS, just a great history lesson on what has happened and no negative information was reported. I've said it many times before, you don't create a $100 Billion Dollar Company in just a few short years. Our science is moving forward rapidly (never fast enough for all of us) but our progress is solid and showing the kind of results needed to meet the end goals. They are talking with many other companies and that is because it is just now becoming clear to the few that our DPC Delivery Platform is something to take very serious. The next 3-4 months will make that more concrete. Enjoy your weekends.

    Sentiment: Strong Buy

  • Just a little information here can clear up a few concerns by some.
    1-Any Toxic via Multi-Dosing seen?
    2-Step-Down KD Advantages seen?
    3-90% KD reached and MAINTAINED seen?
    Have a great meeting everyone. One piece of information at a time. Don't expect too much, but pay attention to the details and decisions made as that will give us insight to what they are seeing to make those decisions, but can't talk about at this time. Another FUN DAY in the beginning period of a Massive Biotech Giant!

    Sentiment: Strong Buy

  • Reply to

    From Dirk's Blog

    by pt117cool Feb 24, 2015 9:47 AM
    wyattkap wyattkap Feb 24, 2015 1:15 PM Flag

    Shorts would be buying the stock to cover at the offering price or even higher as SOME won't sell and try to use this event to either drive the price higher in a deal or push the deal away if the price is not pushed to higher acceptable levels by the majority.

    Sentiment: Strong Buy

ARWR
7.53-0.21(-2.71%)Feb 27 4:00 PMEST

Trending Tickers

i
Trending Tickers features significant U.S. stocks showing the most dramatic increase in user interest in Yahoo Finance in the previous hour over historic norms. The list is limited to those equities which trade at least 100,000 shares on an average day and have a market cap of more than $300 million.