OTTAWA, ONTARIO--(Marketwire -11/25/11)- PharmaGap Inc. (TSX-V: GAP.V - News)(OTC.BB: PHRGF.PK - News) ("PharmaGap" or "the Company") today announced that liposomal formulations of its cancer drug have proven to meet and surpass expectations for three key elements important for clinical trials - potency, pharmacokinetic profile, and therapeutic index. Peptide half-life has been increased from a range of 0.4 to 0.7 for unformulated peptides to approximately 8 hours using intravenous administration and to approximately 40 hours using intraperitoneal administration. Liposomal associated peptide was detectable up to 72 hours post administration indicating that peptide remains in circulation for extended periods of time.
Rats administered liposomes via the intraperitoneal route in the current PK study were observed for clinical signs over 72 hours and results indicate that liposomal formulations would be well tolerated over a wide dosing range (10-40 mg/Kg). These results would be expected to provide a wide therapeutic index (the dosing range between effective dose and the dose at which toxic effects are seen) for drug administered by this route.
In the order of 250,000 new cancer cases annually in the US are known to arise from cancers with origins in the peritoneal cavity. Intraperitoneal injection is an attractive route to deliver liposomal peptides to tumour sites for certain cancers, including ovarian, pancreatic, colorectal, gastric and liver. While focusing on ovarian cancer for definitive efficacy testing to provide proof of concept for first clinical trial application, the Company continues investigation and development of these liposomal peptides in order to expand initial application to other cancer indications for future marketing.
Dr. Ken Sokoll, Vice President of Clinical Development and Chief Operating Officer for PharmaGap, commented "rapid metabolism and elimination of peptide drugs is known to be a major factor contributing to the failure of peptide drugs. Our ability to overcome this problem using these new liposomal formulations and demonstrating that we have viable formulations when administered by both the intravenous and intraperitoneal routes will be key factors in achieving success for our drug compounds."
About PharmaGap Inc.
PharmaGap Inc. (TSX-V: GAP.V - News), based in Ottawa, ON, is a biotechnology company with a core focus on developing novel peptide therapeutics for the treatment of cancer. PharmaGap's GAP-107B8 is a novel peptide drug that has been shown to be effective in numerous cancer types, including chemo-resistant cancers, in vitro. For more information on PharmaGap please visit the Company's website at www.pharmagap.com.
Forward Looking Statements
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Note: Neither the TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release. No Securities Commission or other regulatory authority having jurisdiction over PharmaGap has approved or disapproved of the information contained herein. This release contains forward looking statements that may not occur or may change materially.
President & CEO