IRVINE, Calif., May 5, 2014 /PRNewswire/ -- ChromaDex Corp. (OTCQB: CDXC), an innovative natural products company that provides proprietary ingredients and science-based solutions to the dietary supplement, food and beverage, animal health, cosmetic and pharmaceutical industries, announced today it has entered into a material transfer agreement (MTA) with the Wageningen University in the Netherlands. ChromaDex will provide Wageningen University with quantities of its proprietary NIAGEN™ nicotinamide riboside (NR) ingredient for research use.
ChromaDex's NIAGEN™ is the first and only commercially available form of NR, a naturally-occurring vitamin B3 derivative found in milk. Published research has shown that NR is perhaps the most effective precursor to boost the co-enzyme NAD+ in the cell. NAD+ is arguably the most important cellular co-factor for improvement of mitochondrial performance and energy. In recent years, NAD+ has also been recognized as an extracellular signaling molecule involved in cell-to-cell communication. NAD+ is essential in supporting healthy cellular metabolism including the efficient conversation of blood glucose into energy.
Prof. Jaap Keijer, chair holder of the Human and Animal Physiology Group of Wageningen University, will investigate the health benefits of NR in an experimental model of metabolic disease. Together with Dr. Maria Hegeman and Dr. Dorien van Dartel, he aims to obtain detailed insight in the processes affected by NR which will help to establish optimal dietary NR concentrations to maintain or even improve metabolic health.
Prof. Keijer commented, "It is highly relevant for implementation towards health protection to precisely understand how NR directs tissue NAD metabolism."
"We are glad to add Wageningen University to our list of prestigious partners advancing the understanding of how NR supports human health," said Frank Jaksch, Jr., founder and CEO of ChromaDex. "NIAGEN™ has earned interest from our growing list of commercial partners and the coming wave of academic research will help to solidify the science of NR."
About Nicotinamide Riboside (NR):
Sometimes referred to as the "Miracle Molecule" or "Hidden Vitamin," NR is found naturally in trace amounts in milk and other foods and is a more potent, no-flush version of Niacin (vitamin B3).
Published research has shown that NR is perhaps the most effective NAD+ booster, an essential metabolite found in all cells. NAD+ is arguably the most important cellular co-factor for improvement of mitochondrial performance and energy metabolism. Mitochondria are the powerhouse of the cell where macronutrients are converted to energy the cell can use. Mitochondria also play an important part in the aging process. It is hoped that by stimulating mitochondrial function with the NR molecule, scientists may see increased longevity as well as other health improvements. Researchers worldwide continue seminal discoveries characterizing the unique properties of NR in a wide range of health benefits. These include: increasing mitochondrial health, increasing muscle endurance, neuroprotection, sirtuin activation, protection against weight gain on high fat diet, protection against oxidative stress, improvement of blood glucose and insulin sensitivity. In recent years, NAD+ has also been recognized as an extracellular signaling molecule involved in cell-to-cell communication.
A study by researchers from Harvard Medical School in conjunction with the National Institute on Aging was published in December 2013 in CELL demonstrated that mitochondrial dysfunction (a hallmark of ageing) in ageing mice is due to a disruption in Sirtuin1-dependent nuclear-mitochondrial communication. They further show that a reduction in NAD+ levels is responsible for this disruption. Excitingly, they also show that this mitochondrial dysfunction is readily reversible by administration of a NAD+ precursor. The authors show that "1 week of treatment with a compound that boosts NAD+ levels is sufficient to restore the mitochondrial homeostasis and key biochemical markers of muscle health in a 22-month-old mouse to levels similar to a 6-month-old mouse."
Separately, findings from a 2012 study conducted by researchers at Weill Cornell Medical College and the Ecole Polytechnique Federale de Lausanne, Switzerland researchers showed mice on a high-fat diet that were fed NR gained 60 percent less weight than mice eating the same high-fat diet without NR. Moreover, unlike the mice that were not fed NR, none of the NR-treated mice had indications that they were developing diabetes and they had improved energy and lower cholesterol levels, all without side effects. The Swiss researchers were quoted as saying the effects of NR on metabolism "are nothing short of astonishing."
About Wageningen University:
Wageningen University is part of Wageningen UR (University & Research centre). The mission is 'To explore the potential of nature to improve the quality of life'. Within Wageningen UR, nine research institutes both specialized and applied have joined forces with Wageningen University to help answer the most important questions in the domain of healthy food and living environment. With approximately 30 locations (in the Netherlands, Brazil, Chile, Ethiopia and China), 6,000 members of staff and 9,000 students, Wageningen UR is one of the leading organizations in its domain worldwide. The integral approach to problems and the cooperation between the exact sciences and the technological and social disciplines are at the heart of the Wageningen Approach. For more information about Wageningen University & Research centre, please visit www.wageningenur.nl.
ChromaDex is an innovative natural products company that discovers, acquires, develops and commercializes proprietary-based ingredient technologies through its unique business model that utilizes its wholly owned synergistic business units, including ingredient technologies, natural product fine chemicals (known as "phytochemicals"), chemistry and analytical testing services, and product regulatory and safety consulting (as Spherix Consulting). The company provides seamless science-based solutions to the nutritional supplement, food and beverage, animal health, cosmetic and pharmaceutical industries. The ChromaDex ingredient technologies unit includes products backed with extensive scientific research and intellectual property. Its ingredient portfolio includes pTeroPure® pterostilbene; ProC3G®, a natural black rice containing cyanidin-3-glucoside; PURENERGY™, a caffeine-pTeroPure co-crystal; and NIAGEN™, its recently launched branded nicotinamide riboside, a novel next-generation B vitamin. To learn more about ChromaDex, visit www.chromadex.com.
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