Idera Pharmaceuticals announces positive data from studies of TLRs

Idera Pharmaceuticals announced new data from preclinical studies showing that selective inhibition of Toll-like Receptors, or TLRs 7, 8, and 9, which play a key role in inflammation and immunity, also resulted in inhibition of inflammasome activation and induction of Interleukin 1 beta, a pro-inflammatory cytokine that has been shown to be involved in Behçet's disease, non-infectious uveitis, cardiovascular disease, and other auto-inflammatory diseases. The data were presented during the 8 Annual Meeting of the Oligonucleotide Therapeutics Society being held October 28-31, 2012 in Boston.