WINNIPEG, MANITOBA--(Marketwire - May 30, 2012) - Kane Biotech Inc. (KNE.V - News), a biotechnology company engaged in the development and commercialization of products that prevent and remove microbial biofilms, is pleased to announce that the Company has filed the PCT (Patent Cooperation Treaty) on its bone tissue regeneration technology with the World Intellectual Property Organization (WIPO). The patent is examined by a central authority before moving on to the national stage, during which the application can issue as a patent from any of the countries that are parties to the PCT.
The experimental results from a collaborative research study demonstrate the osteogenic (bone regenerating) activity of the Company's CSP (competence stimulating peptide) technology based fusion polypeptide. The bone regenerating activity of the fusion peptide was confirmed by the experiments to determine: (i) osteoblast (bone cell) precursor stem cell adhesion and proliferation, (ii) osteroblast differentiation based on alkaline phosphatase activity, and (iii) calcium mineralization estimation using alizarin red staining method. The CSP-based fusion polypeptide promoted cell adhesion and osteogenic activity significantly better compared to CSP alone and a known osteogenic peptide (control) tested in this study.
This invention targets a global market for bone tissue regeneration of over $32 billion a year and is valuable for: (i) repairing dental bone defects such as those caused by bone loss resulting from moderate to severe periodontitis and augmenting of bone defects of the alveolar ridge; (ii) filling tooth extraction sites and sinus elevation grafting; (iii) treatment of fractures; and (iv) prevention of fractures associated with osteoporosis and rheumatoid arthritis.
"The confirmed superior osteogenic activity of our CSP-based fusion peptide gives us the confidence to develop this technology further for applications in the fast growing field of tissue engineering," stated Dr. Sri Madhyastha, Vice President of Research and Chief Scientific Officer of Kane Biotech. "An NSERC-Engage Grant Program (Natural Sciences and Engineering Research Council of Canada) will support further collaborative research on our bone regenerating technology".
About Kane Biotech Inc.
Kane Biotech is a biotechnology company engaged in the development and commercialization of products to prevent and remove biofilms. Biofilms are a major cause of a number of serious medical problems such as catheters, prosthetic implants, teeth, lungs, and the urogenital tract. Biofilms are pervasive, costly to deal with and are involved in approximately 80% of all human bacterial infections. The healing of chronic wounds alone cost the United States health care system $20 Billion per year.
Kane Biotech uses patent protected technologies based on molecular mechanisms of biofilm formation/dispersal and methods for finding compounds that inhibit or disrupt biofilms. The Company has evidence that these technologies have potential to significantly improve the ability to prevent and/or destroy biofilms in several medical and industrial applications.
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