Wall Street Transcript Interview with Aethlon Medical, Inc. (AEMD) CEO James A. Joyce

Wall Street Transcript

67 WALL STREET, New York - August 29, 2012 - The Wall Street Transcript has just published its Medical Research, Diagnostic Substances and Life Science Tools Report offering a timely review of the sector to serious investors and industry executives. This special feature contains expert industry commentary through in-depth interviews with public company CEOs, Equity Analysts and Money Managers. The full issue is available by calling (212) 952-7433 or via The Wall Street Transcript Online.

Topics covered: Health Care Consolidation Activity - Cost Reduction and Improving Efficiencies - Chinese CRO Growth - NIH Budget Uncertainty

Companies include: Aethlon Medical (AEMD) and many others.

In the following excerpt from the Medical Research, Diagnostic Substances and Life Science Tools Report, the CEO of Aethlon Medical discusses the outlook for his company for investors:

TWST:Would you begin with a brief historical sketch of the company and a picture of its operations at the present time?

Mr. Joyce: I formed Aethlon Medical with the vision that we could create a medical device that would selectively eliminate disease-causing factors from the entire circulatory system, and do so without drug toxicity. I'm proud to say that just over a decade later, we've transformed that vision into a reality. We're now creating medical-device-based therapies to address unmet medical needs in cancer, hepatitis C and other major market disease conditions.

We've also received a contract from the U.S. government to create a device that will reduce the incidence of sepsis, which is

often the cause of death in wounded war fighters.

TWST: Please tell us briefly about the science behind these therapies. It sounds as if Aethlon Medical developed numerous products from one platform.

Mr. Joyce: In the beginning, the idea of selectively eliminating hepatitis-C- or cancer-promoting factors from the entire circulatory system was theoretical, at best. However, from a science perspective, we believed that intersecting the capabilities of affinity drug agents with advanced plasma filtration membranes would result in a platform technology that would support our therapeutic objectives. We call this platform the Aethlon ADAPT System, which is an acronym for adaptive dialysis-like affinity platform technology. The ADAPT system allows us to immobilize single or multiple affinity agents within a medical device designed to subtract deleterious targets from circulation versus adding toxic drug agents into circulation.

Our lead product from the ADAPT system is the Aethlon Hemopurifier. The Hemopurifier has demonstrated broad spectrum capabilities against infectious viral pathogens that include bioterror threats, pandemic threats and HIV. In human studies, our primary focus to date has been hepatitis C. We have approximately 100 hepatitis C treatments under our belt, and we've demonstrated that the Hemopurifier can rapidly reduce viral load. We are now preparing to initiate commercialization of the Hemopurifier overseas and anticipate the initiation of human clinical programs in the United States early next year.

We've also discovered that our Hemopurifier is able to capture cancer-secreted exosomes, which are extremely immunosuppressive in cancer patients. Exosomes have also been reported to promote angiogenesis, which is the ability for tumors to create their own blood supply for survival, and in the latest issue of the journal Nature, exosomes were reported to seed the spread of metastasis in cancer patients. That said, exosomes represent a critically important target that can be addressed by our Hemopurifier, yet remain beyond the reach of traditional drug therapies.

TWST: So potentially, there's a gigantic market for these therapies?

For more from this interview and many others visit the Wall Street Transcript - a unique service for investors and industry researchers - providing fresh commentary and insight through verbatim interviews with CEOs and research analysts. This special issue is available by calling (212) 952-7433 or via The Wall Street Transcript Online.

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