| UPGRADES & DOWNGRADES HISTORY |
| Date | Research Firm | Action | From | To | | 25-Oct-05 | Leerink Swann | Initiated | | Outperform | | 25-Aug-05 | CIBC Wrld Mkts | Initiated | | Sector Outperform | | 30-Mar-05 | Punk, Ziegel & Co | Initiated | | Buy | | 20-Sep-04 | Lazard Freres | Initiated | | Buy |
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| Current Month | Last Month | Two Months Ago | Three Months Ago | | Strong Buy | | | | | | Buy | | | | | | Hold | | | | | | Underperform | | | | | | Sell | | | | |
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