| Date | Event |
| 10-Feb-10 | ISIS PHARMACEUTICALS INC Files SEC form 8-K, Other Events, Financial Statements and Exhibits |
| 14-Dec-09 | Price hit new 52-week low ($9.77) |
| 11-Dec-09 | Price hit new 52-week low ($9.88) |
| 8-Dec-09 | ISIS PHARMACEUTICALS INC Files SEC form 8-K, Entry into a Material Definitive Agreement |
| 8-Dec-09 | Price hit new 52-week low ($10.33) |
| 17-Nov-09 | ISIS PHARMACEUTICALS INC Files SEC form 8-K, Other Events, Financial Statements and Exhibits |
| 6-Nov-09 | ISIS PHARMACEUTICALS INC Files SEC form 10-Q, Quarterly Report |
| 5-Nov-09 | ISIS PHARMACEUTICALS INC Files SEC form 8-K, Results of Operations and Financial Condition, Financial Statements and |
| 21-Oct-09 | ISIS PHARMACEUTICALS INC Files SEC form 8-K, Other Events, Financial Statements and Exhibits |
| 2-Oct-09 | ISIS PHARMACEUTICALS INC Files SEC form 8-K/A, Entry into a Material Definitive Agreement, Creation of a Direct Finan |
| 6-Aug-09 | ISIS PHARMACEUTICALS INC Files SEC form 8-K, Results of Operations and Financial Condition, Financial Statements and |
| 30-Jul-09 | Price hit new 52-week high ($18.60) |
| 29-Jul-09 | Price hit new 52-week high ($18.24) |
| 4-Jun-09 | ISIS PHARMACEUTICALS INC Files SEC form 8-K, Amendments to Articles of Inc. or Bylaws; Change in Fiscal Year, Financi |
| 20-May-09 | ISIS PHARMACEUTICALS INC Files SEC form 8-K, Other Events, Financial Statements and Exhibits |
| 7-May-09 | ISIS PHARMACEUTICALS INC Files SEC form 8-K, Results of Operations and Financial Condition, Financial Statements and |
| 29-Apr-09 | ISIS PHARMACEUTICALS INC Files SEC form 8-K, Entry into a Material Definitive Agreement |
| 22-Apr-09 | Price hit new 52-week high ($16.05) |
| 15-Apr-09 | ISIS PHARMACEUTICALS INC Files SEC form 8-K, Other Events, Financial Statements and Exhibits |
| 30-Mar-09 | ISIS PHARMACEUTICALS INC Files SEC form 8-K/A, Entry into a Material Definitive Agreement, Creation of a Direct Finan |
| 4-Mar-09 | ISIS PHARMACEUTICALS INC Files SEC form 8-K, Entry into a Material Definitive Agreement, Financial Statements and Exh |
| 26-Feb-09 | ISIS PHARMACEUTICALS INC Files SEC form 10-K, Annual Report |
| 25-Feb-09 | ISIS PHARMACEUTICALS INC Files SEC form 8-K, Results of Operations and Financial Condition, Financial Statements and |
| 12-Jan-09 | ISIS PHARMACEUTICALS INC Files SEC form 8-K/A, Entry into a Material Definitive Agreement, Completion of Acquisition |