ISIS: Historical Prices for Isis Pharmaceuticals, Inc.

Date	Open	High	Low	Close	Volume	Adj Close*
20-Nov-09	10.95	11.24	10.90	11.23	1,435,200	11.23
19-Nov-09	11.20	11.30	10.92	11.03	2,087,400	11.03
18-Nov-09	11.44	11.63	11.11	11.20	4,165,200	11.20
17-Nov-09	13.40	13.78	10.73	11.12	13,238,900	11.12
16-Nov-09	13.01	13.45	13.01	13.40	1,702,900	13.40
13-Nov-09	13.40	13.49	12.99	13.11	1,266,100	13.11
12-Nov-09	13.58	13.67	13.37	13.40	696,100	13.40
11-Nov-09	13.63	13.83	13.39	13.56	1,037,600	13.56
10-Nov-09	13.50	13.77	13.45	13.48	724,100	13.48
9-Nov-09	13.50	13.69	13.44	13.58	943,300	13.58
6-Nov-09	13.42	13.74	13.29	13.46	1,150,100	13.46
5-Nov-09	13.05	13.83	12.73	13.55	1,617,200	13.55
4-Nov-09	12.66	12.78	12.53	12.56	1,128,100	12.56
3-Nov-09	12.29	12.68	12.25	12.66	797,200	12.66
2-Nov-09	12.78	12.89	12.29	12.38	1,505,900	12.38
30-Oct-09	12.50	12.81	12.41	12.67	1,554,400	12.67
29-Oct-09	12.46	12.65	12.40	12.52	941,400	12.52
28-Oct-09	12.80	12.91	12.25	12.31	1,835,600	12.31
27-Oct-09	13.25	13.36	12.80	12.82	1,395,400	12.82
26-Oct-09	13.82	13.93	13.14	13.16	1,238,000	13.16
23-Oct-09	13.88	13.90	13.64	13.85	1,524,900	13.85
22-Oct-09	13.70	13.84	13.46	13.80	1,493,900	13.80
21-Oct-09	13.65	13.82	13.24	13.27	1,584,800	13.27
20-Oct-09	13.97	14.00	13.64	13.66	1,074,100	13.66
19-Oct-09	14.05	14.09	13.77	13.98	802,000	13.98
16-Oct-09	13.75	14.02	13.62	13.96	1,085,100	13.96
15-Oct-09	13.81	14.00	13.77	13.86	1,313,400	13.86
14-Oct-09	13.72	13.94	13.64	13.94	974,500	13.94
13-Oct-09	13.86	14.02	13.52	13.55	1,117,800	13.55
12-Oct-09	14.10	14.10	13.85	13.86	373,800	13.86
9-Oct-09	13.77	14.03	13.77	14.02	370,700	14.02
8-Oct-09	14.04	14.05	13.79	13.82	850,300	13.82
7-Oct-09	14.15	14.15	13.75	13.88	1,076,300	13.88
6-Oct-09	13.81	14.17	13.76	14.16	1,040,300	14.16
5-Oct-09	13.90	14.04	13.75	13.76	958,800	13.76
2-Oct-09	14.00	14.15	13.87	13.88	809,100	13.88
1-Oct-09	14.55	14.59	14.01	14.02	843,500	14.02
30-Sep-09	14.90	14.98	14.46	14.57	643,500	14.57
29-Sep-09	15.07	15.14	14.79	14.83	578,700	14.83
28-Sep-09	14.60	15.11	14.56	15.05	617,200	15.05
25-Sep-09	14.87	15.03	14.52	14.56	758,400	14.56
24-Sep-09	15.19	15.38	14.82	14.84	724,800	14.84
23-Sep-09	15.16	15.46	15.09	15.18	810,000	15.18
22-Sep-09	15.23	15.35	14.91	15.09	899,300	15.09
21-Sep-09	15.06	15.36	15.06	15.20	486,400	15.20
18-Sep-09	15.25	15.41	14.80	15.24	1,164,600	15.24
17-Sep-09	15.15	15.37	15.12	15.23	638,900	15.23
16-Sep-09	15.52	15.52	15.03	15.12	1,322,300	15.12
15-Sep-09	15.70	15.81	15.40	15.52	453,700	15.52
14-Sep-09	15.34	15.67	15.33	15.66	850,700	15.66
11-Sep-09	15.84	15.84	15.30	15.49	575,100	15.49
10-Sep-09	15.61	15.76	15.50	15.66	545,600	15.66
9-Sep-09	15.38	15.67	15.27	15.53	547,400	15.53
8-Sep-09	15.55	15.60	15.19	15.43	476,200	15.43
4-Sep-09	15.25	15.52	15.03	15.48	477,000	15.48
3-Sep-09	15.55	15.73	15.04	15.24	646,300	15.24
2-Sep-09	15.60	15.73	15.50	15.53	415,400	15.53
1-Sep-09	16.05	16.53	15.60	15.69	832,100	15.69
31-Aug-09	16.01	16.35	15.96	16.14	717,700	16.14
28-Aug-09	16.65	16.65	16.11	16.15	455,700	16.15
27-Aug-09	16.27	16.48	16.04	16.47	814,600	16.47
26-Aug-09	16.00	16.37	16.00	16.27	816,600	16.27
25-Aug-09	16.03	16.21	15.86	16.00	865,900	16.00
24-Aug-09	15.91	16.17	15.85	16.00	483,100	16.00
21-Aug-09	15.74	15.98	15.54	15.92	672,500	15.92
20-Aug-09	15.44	15.63	15.38	15.52	450,900	15.52
* Close price adjusted for dividends and splits.

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