ISIS: Historical Prices for Isis Pharmaceuticals, Inc.

Date	Open	High	Low	Close	Volume	Adj Close*
21-Dec-09	10.05	10.07	9.92	10.04	1,225,200	10.04
18-Dec-09	10.22	10.22	9.86	9.94	2,520,500	9.94
17-Dec-09	10.16	10.20	9.88	9.95	1,135,400	9.95
16-Dec-09	10.07	10.19	10.01	10.19	1,364,500	10.19
15-Dec-09	9.98	10.10	9.84	10.00	1,249,500	10.00
14-Dec-09	10.00	10.10	9.77	9.98	1,342,400	9.98
11-Dec-09	10.17	10.22	9.88	9.98	1,949,900	9.98
10-Dec-09	10.25	10.34	10.06	10.15	1,246,800	10.15
9-Dec-09	10.50	10.58	10.13	10.22	1,607,700	10.22
8-Dec-09	10.44	10.67	10.33	10.53	2,277,300	10.53
7-Dec-09	10.53	10.64	10.39	10.54	906,200	10.54
4-Dec-09	10.76	10.88	10.39	10.53	1,768,700	10.53
3-Dec-09	10.71	10.81	10.60	10.61	859,200	10.61
2-Dec-09	10.58	10.68	10.52	10.64	1,114,000	10.64
1-Dec-09	10.75	10.93	10.57	10.58	2,141,200	10.58
30-Nov-09	10.95	10.96	10.65	10.71	1,945,900	10.71
27-Nov-09	10.95	11.17	10.95	11.00	394,000	11.00
25-Nov-09	11.15	11.23	11.10	11.19	636,600	11.19
24-Nov-09	11.14	11.24	11.01	11.14	767,400	11.14
23-Nov-09	11.40	11.47	11.06	11.15	1,416,200	11.15
20-Nov-09	10.95	11.24	10.90	11.23	1,435,200	11.23
19-Nov-09	11.20	11.30	10.92	11.03	2,087,400	11.03
18-Nov-09	11.44	11.63	11.11	11.20	4,165,200	11.20
17-Nov-09	13.40	13.78	10.73	11.12	13,238,900	11.12
16-Nov-09	13.01	13.45	13.01	13.40	1,702,900	13.40
13-Nov-09	13.40	13.49	12.99	13.11	1,266,100	13.11
12-Nov-09	13.58	13.67	13.37	13.40	696,100	13.40
11-Nov-09	13.63	13.83	13.39	13.56	1,037,600	13.56
10-Nov-09	13.50	13.77	13.45	13.48	724,100	13.48
9-Nov-09	13.50	13.69	13.44	13.58	943,300	13.58
6-Nov-09	13.42	13.74	13.29	13.46	1,150,100	13.46
5-Nov-09	13.05	13.83	12.73	13.55	1,617,200	13.55
4-Nov-09	12.66	12.78	12.53	12.56	1,128,100	12.56
3-Nov-09	12.29	12.68	12.25	12.66	797,200	12.66
2-Nov-09	12.78	12.89	12.29	12.38	1,505,900	12.38
30-Oct-09	12.50	12.81	12.41	12.67	1,554,400	12.67
29-Oct-09	12.46	12.65	12.40	12.52	941,400	12.52
28-Oct-09	12.80	12.91	12.25	12.31	1,835,600	12.31
27-Oct-09	13.25	13.36	12.80	12.82	1,395,400	12.82
26-Oct-09	13.82	13.93	13.14	13.16	1,238,000	13.16
23-Oct-09	13.88	13.90	13.64	13.85	1,524,900	13.85
22-Oct-09	13.70	13.84	13.46	13.80	1,493,900	13.80
21-Oct-09	13.65	13.82	13.24	13.27	1,584,800	13.27
20-Oct-09	13.97	14.00	13.64	13.66	1,074,100	13.66
19-Oct-09	14.05	14.09	13.77	13.98	802,000	13.98
16-Oct-09	13.75	14.02	13.62	13.96	1,085,100	13.96
15-Oct-09	13.81	14.00	13.77	13.86	1,313,400	13.86
14-Oct-09	13.72	13.94	13.64	13.94	974,500	13.94
13-Oct-09	13.86	14.02	13.52	13.55	1,117,800	13.55
12-Oct-09	14.10	14.10	13.85	13.86	373,800	13.86
9-Oct-09	13.77	14.03	13.77	14.02	370,700	14.02
8-Oct-09	14.04	14.05	13.79	13.82	850,300	13.82
7-Oct-09	14.15	14.15	13.75	13.88	1,076,300	13.88
6-Oct-09	13.81	14.17	13.76	14.16	1,040,300	14.16
5-Oct-09	13.90	14.04	13.75	13.76	958,800	13.76
2-Oct-09	14.00	14.15	13.87	13.88	809,100	13.88
1-Oct-09	14.55	14.59	14.01	14.02	843,500	14.02
30-Sep-09	14.90	14.98	14.46	14.57	643,500	14.57
29-Sep-09	15.07	15.14	14.79	14.83	578,700	14.83
28-Sep-09	14.60	15.11	14.56	15.05	617,200	15.05
25-Sep-09	14.87	15.03	14.52	14.56	758,400	14.56
24-Sep-09	15.19	15.38	14.82	14.84	724,800	14.84
23-Sep-09	15.16	15.46	15.09	15.18	810,000	15.18
22-Sep-09	15.23	15.35	14.91	15.09	899,300	15.09
21-Sep-09	15.06	15.36	15.06	15.20	486,400	15.20
18-Sep-09	15.25	15.41	14.80	15.24	1,164,600	15.24
* Close price adjusted for dividends and splits.

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