| Individual/Entity | Most Recent Trans. | Shares Owned as of Trans. Date |
|---|
ABINGWORTH LLP Beneficial Owner (10% or more) | Sale Apr 18, 2012 | 1,599,168
Apr 18, 2012 | ANDERSON JOSEPH Director | Acquisition (Non Open Market) Oct 10, 2011 | 11,683 Oct 10, 2011 | GORDON CARL L Director | Automatic Sale Sep 3, 2012 | 5,700
Sep 3, 2012 | HEALY JAMES Director | Option Exercise Aug 30, 2012 | 6,411,588 Aug 30, 2012 | HUFF PAUL Officer | Sale Jul 26, 2012 | 0 Jul 26, 2012 | KENNEDY JOSEPH T Officer | Automatic Sale Jul 26, 2012 | 0 Jul 26, 2012 | ORBIMED ADVISORS LLC Director | Automatic Sale Sep 3, 2012 | 5,700
Sep 3, 2012 | SEDLACK STUART D Officer | Automatic Sale Jul 26, 2012 | 0 Jul 26, 2012 | THERO JOHN F Officer | Option Exercise Jan 29, 2013 | 39,450 Jan 29, 2013 | VAN HEEK G JAN Director | Acquisition (Non Open Market) Apr 9, 2013 | 23,448 Apr 9, 2013 | ZAKRZEWSKI JOSEPH S Officer | Option Exercise Apr 24, 2013 | 121,937 Apr 24, 2013 |
|