| Individual/Entity | Most Recent Trans. | Shares Owned as of Trans. Date | ALTA PARTNERS VIII, L.P. Beneficial Owner (10% or more) | Ownership Statement 18-Dec-07 | 6,172,840
18-Dec-07 | CAMPBELL JAMES N Director | Purchase 8-Sep-08 | 114,000 8-Sep-08 | INTERWEST PARTNERS VIII LP Beneficial Owner (10% or more) | Purchase 18-Dec-07 | 4,759,654 18-Dec-07 | JANNEY DANIEL Director | Ownership Statement 6-Feb-08 | 6,172,840
6-Feb-08 | ORONSKY ARNOLD L Director | Purchase 18-Dec-07 | 4,627,266
18-Dec-07 | POWELL MICHAEL Director | Purchase 18-Dec-07 | 3,703,704
18-Dec-07 | SOFINNOVA VENTURE PARTNERS V LP Beneficial Owner (10% or more) | Ownership Statement 18-Dec-07 | 3,703,704 18-Dec-07 | VIRET JEAN-FREDERIC Officer | Ownership Statement 1-Mar-08 | 6,541 1-Mar-08 |
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