| Individual/Entity | Most Recent Trans. | Shares Owned as of Trans. Date | ADELMAN ROBERT J Director | Purchase 14-Nov-08 | 3,340,139
14-Nov-08 | BASKETT FOREST Beneficial Owner (10% or more) | Ownership Statement 14-Nov-08 | 4,469,274
14-Nov-08 | DRANT RYAN D Beneficial Owner (10% or more) | Ownership Statement 14-Nov-08 | 4,469,274
14-Nov-08 | DRUZGALA PASCAL Officer | Disposition (Non Open Market) 17-Aug-09 | 0
17-Aug-09 | EVNIN LUKE Beneficial Owner (10% or more) | Purchase 14-Nov-08 | 5,364,572
14-Nov-08 | GROWTH EQUITY OPPORTUNITIES FUND, LLC Beneficial Owner (10% or more) | Ownership Statement 14-Nov-08 | 4,469,274 14-Nov-08 | KERINS PATRICK J Beneficial Owner (10% or more) | Ownership Statement 14-Nov-08 | 4,469,274
14-Nov-08 | KOLLURI KRISHNA KITTU Beneficial Owner (10% or more) | Ownership Statement 14-Nov-08 | 4,469,274
14-Nov-08 | LINEHAN CHARLES M Beneficial Owner (10% or more) | Ownership Statement 14-Nov-08 | 4,469,274
14-Nov-08 | MPM BIOVENTURES III-QP L.P. Beneficial Owner (10% or more) | Purchase 14-Nov-08 | 5,364,572
14-Nov-08 | ORBIMED ADVISORS LLC Beneficial Owner (10% or more) | Sale 22-May-09 | 1,340,139
22-May-09 | SIMON NICHOLAS J III Director | Purchase 14-Nov-08 | 5,364,572
14-Nov-08 | TRAINOR III EUGENE A Beneficial Owner (10% or more) | Ownership Statement 14-Nov-08 | 4,469,274
14-Nov-08 |
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