| Individual/Entity | Most Recent Trans. | Shares Owned as of Trans. Date | AKER HAZEL M Officer | Acquisition (Non Open Market) 20-Feb-08 | 3,745 20-Feb-08 | ATWOOD BRIAN G Director | Acquisition (Non Open Market) 18-Feb-09 | 1,381,632
18-Feb-09 | BARKER SAM L Director | Purchase 17-Mar-08 | 6,000 17-Mar-08 | BERMAN MICHAEL A Director | Acquisition (Non Open Market) 18-Aug-09 | 39,920 18-Aug-09 | BLAIR JAMES C Director | Purchase 18-Feb-09 | 2,734,040
18-Feb-09 | BREITMEYER JAMES B Officer | Option Exercise 5-Nov-09 | 10,000 5-Nov-09 | BYRD SCOTT A. Officer | Ownership Statement 24-Jun-09 | 0 24-Jun-09 | CRAIG WILLIAM S Officer | Option Exercise 20-Oct-09 | 2,000 20-Oct-09 | DOMAIN PARTERS VII L P Beneficial Owner (10% or more) | Ownership Statement 18-Feb-09 | 2,734,040 18-Feb-09 | DOMAIN PARTNERS VI, L.P. Beneficial Owner (10% or more) | Acquisition (Non Open Market) 20-Feb-08 | 8,432,241 20-Feb-08 | DOVEY BRIAN H Beneficial Owner (10% or more) | Purchase 18-Feb-09 | 2,734,040
18-Feb-09 | DP VI ASSOCIATES, L.P. Beneficial Owner (10% or more) | Acquisition (Non Open Market) 20-Feb-08 | 90,369 20-Feb-08 | DP VII ASSOCIATES LP Beneficial Owner (10% or more) | Ownership Statement 18-Feb-09 | 46,634 18-Feb-09 | FRAZIER ALAN D Director | Acquisition (Non Open Market) 18-Feb-09 | 4,720,243
18-Feb-09 | FRAZIER HEALTHCARE V, LP Beneficial Owner (10% or more) | Purchase 18-Feb-09 | 9,440,486 18-Feb-09 | FRAZIER HEALTHCARE VI, L.P. Beneficial Owner (10% or more) | Ownership Statement 18-Feb-09 | 6,256,516 18-Feb-09 | GARNER CAM L Director | Sale 10-Sep-09 | 540,888
10-Sep-09 | HALAK BRIAN K Beneficial Owner (10% or more) | Purchase 18-Feb-09 | 2,734,040
18-Feb-09 | LARUE WILLIAM R Officer | Acquisition (Non Open Market) 20-Feb-08 | 5,000 20-Feb-08 | MORE ROBERT J Beneficial Owner (10% or more) | Acquisition (Non Open Market) 20-Feb-08 | 8,432,241
20-Feb-08 | RICH TODD W Director | Ownership Statement 26-Aug-08 | 0 26-Aug-08 | ROYAL MIKE A Officer | Acquisition (Non Open Market) 20-Feb-08 | 2,000 20-Feb-08 | SCHOEMAKER KATHLEEN K Beneficial Owner (10% or more) | Purchase 18-Feb-09 | 2,734,040
18-Feb-09 | SCHROEDER THEODORE R Officer | Automatic Sale 16-Oct-09 | 491,000
16-Oct-09 | SOCKS DAVID A Officer | Automatic Sale 9-Nov-09 | 153,745 9-Nov-09 | TREU JESSE I Beneficial Owner (10% or more) | Purchase 18-Feb-09 | 2,734,040
18-Feb-09 | TWOMEY CHRISTOPHER J Director | Acquisition (Non Open Market) 20-Feb-08 | 35,000
20-Feb-08 | VITULLO NICOLE Beneficial Owner (10% or more) | Purchase 18-Feb-09 | 2,734,040
18-Feb-09 |
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