| Individual/Entity | Most Recent Trans. | Shares Owned as of Trans. Date | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | Purchase 14-Oct-08 | 7,542,888 14-Oct-08 | FELDMAN FREDRIC J Director | Purchase 30-Mar-09 | 169,564 30-Mar-09 | HOLLIMAN JOHN M III Officer | Acquisition (Non Open Market) 14-Apr-09 | 202,614 14-Apr-09 | HOWSE ELWOOD D Director | Purchase 31-Mar-09 | 142,703 31-Mar-09 | SHINBAUM DANA B Officer | Acquisition (Non Open Market) 21-Feb-08 | 43,811 21-Feb-08 | STEER RANDOLPH C Officer | Acquisition (Non Open Market) 11-Jun-09 | 45,298 11-Jun-09 | TAEGER LESLIE M Officer | Acquisition (Non Open Market) 21-Feb-08 | 44,574 21-Feb-08 | WARDELL WILLIAM M Director | Purchase 30-Apr-09 | 84,542 30-Apr-09 | WHITE AUGUSTUS A Director | Acquisition (Non Open Market) 23-Mar-09 | 123,501 23-Mar-09 |
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