| Individual/Entity | Most Recent Trans. | Shares Owned as of Trans. Date | BUC NANCY L Director | Purchase 9-May-08 | 5,000 9-May-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | Sale 10-Sep-09 | 12,389,508 10-Sep-09 | CARSON DENNIS Director | Automatic Sale 20-Dec-07 | 88,119
20-Dec-07 | DINA DINO Officer | Purchase 5-May-08 | 118,273 5-May-08 | FLYNN JAMES E Beneficial Owner (10% or more) | Sale 22-Oct-08 | 0
22-Oct-08 | LEW JENNIFER Officer | Ownership Statement 5-Jun-09 | 2,332 5-Jun-09 | PHILLIPS PEGGY V Director | Purchase 6-May-08 | 45,000 6-May-08 | SANDERS MARTIN E Officer | Ownership Statement 25-Feb-08 | 33,766 25-Feb-08 |
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