| Individual/Entity | Most Recent Trans. | Shares Owned as of Trans. Date | BARRETT M JAMES Director | Purchase 28-Oct-09 | 6,898,294
28-Oct-09 | BARRIS PETER J Beneficial Owner (10% or more) | Purchase 28-Oct-09 | 6,898,294
28-Oct-09 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | Ownership Statement 30-Dec-08 | 8,983,787 30-Dec-08 | CERRONE GABRIEL Director | Acquisition (Non Open Market) 17-Mar-08 | 2,102,100 17-Mar-08 | HAMM ROBERT A Director | Disposition (Non Open Market) 3-Jul-08 | 37,795 3-Jul-08 | HENOS MICHAEL A Director | Disposition (Non Open Market) 3-Jul-08 | 3,006,673 3-Jul-08 | HENSON GEOFFREY W. Officer | Purchase 3-Dec-08 | 154,666 3-Dec-08 | KRAMLICH C RICHARD Beneficial Owner (10% or more) | Purchase 28-Oct-09 | 6,898,294
28-Oct-09 | MEDFORD RUSSELL M Director | Disposition (Non Open Market) 3-Jul-08 | 37,795 3-Jul-08 | NEW ENTERPRISE ASSOCIATES 10 L P Beneficial Owner (10% or more) | Purchase 28-Oct-09 | 6,898,294 28-Oct-09 | NEWHALL CHARLES W III Beneficial Owner (10% or more) | Purchase 28-Oct-09 | 6,898,294
28-Oct-09 | PATTI JOSEPH M Officer | Purchase 14-Nov-08 | 139,335 14-Nov-08 | PERRY MARK W Beneficial Owner (10% or more) | Purchase 28-Oct-09 | 6,898,294
28-Oct-09 | PLUMB RUSSELL H Officer | Disposition (Non Open Market) 6-Jan-09 | 347,857 6-Jan-09 | PREMINGER MARC L Director | Disposition (Non Open Market) 3-Jul-08 | 50,574 3-Jul-08 | QVT ASSOCIATES GP LLC Beneficial Owner (10% or more) | Purchase 25-Nov-09 | 8,824,953
25-Nov-09 | SANDELL SCOTT D Beneficial Owner (10% or more) | Purchase 28-Oct-09 | 6,898,294
28-Oct-09 | TRAINOR III EUGENE A Beneficial Owner (10% or more) | Purchase 28-Oct-09 | 6,898,294
28-Oct-09 |
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