| Individual/Entity | Most Recent Trans. | Shares Owned as of Trans. Date | ARYEH JASON Director | Acquisition (Non Open Market) 29-May-08 | 39,700 29-May-08 | BERKMAN CHARLES S Officer | Acquisition (Non Open Market) 15-Feb-09 | 55,263 15-Feb-09 | BURAKOFF STEVEN J Director | Acquisition (Non Open Market) 23-Dec-08 | 10,000 23-Dec-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | Sale 24-Aug-09 | 26,623,615 24-Aug-09 | DAVIS TODD C Director | Acquisition (Non Open Market) 29-May-08 | 10,000 29-May-08 | DZIEWANOWSKA ZOFIA E Officer | Sale 25-Feb-09 | 33,977 25-Feb-09 | GREETHAM ELIZABETH M Director | Acquisition (Non Open Market) 29-May-08 | 10,000 29-May-08 | HIGGINS JOHN L Officer | Acquisition (Non Open Market) 15-Feb-09 | 332,000 15-Feb-09 | KAZMI SYED Officer | Acquisition (Non Open Market) 15-Feb-09 | 59,710 15-Feb-09 | KNOTT DAVID M Director | Purchase 7-Apr-09 | 3,379,983 7-Apr-09 | KOZARICH JOHN W Director | Acquisition (Non Open Market) 29-May-08 | 25,378 29-May-08 | LIGAND PHARMACEUTICALS INC Director | Acquisition (Non Open Market) 4-Aug-08 | 10,000 4-Aug-08 | MEGLASSON MARTIN Officer | Acquisition (Non Open Market) 15-Feb-09 | 67,000 15-Feb-09 | PEACOCK BRUCE Director | Acquisition (Non Open Market) 23-Dec-08 | 10,000 23-Dec-08 | PERRY JEFFREY R Director | Acquisition (Non Open Market) 29-May-08 | 33,953 29-May-08 | SABBA STEPHEN L Director | Ownership Statement 4-Aug-08 | 10,000 4-Aug-08 | SHARP JOHN P Officer | Acquisition (Non Open Market) 15-Feb-09 | 58,000 15-Feb-09 |
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