| Individual/Entity | Most Recent Trans. | Shares Owned as of Trans. Date | CREDIT SUISSE AG/
Beneficial Owner (10% or more) | Purchase
16-Apr-08 | 3,863,422
16-Apr-08 | EVNIN LUKE
Director | Option Exercise
16-Apr-08 | 4,814,725
16-Apr-08 | GUMBINER BARRY
Officer | Ownership Statement
12-Nov-08 | 6,891
12-Nov-08 | HALE DAVID F
Director | Option Exercise
16-Apr-08 | 60,337
16-Apr-08 | INTERWEST PARTNERS VII L P
Beneficial Owner (10% or more) | Option Exercise
16-Apr-08 | 3,895,252
16-Apr-08 | LAIKIND PAUL K
Officer | Purchase
19-Nov-08 | 707,220
19-Nov-08 | MILLICAN TRISHA
Officer | Ownership Statement
9-May-08 | 1,151
9-May-08 | MPM BIOVENTURES II QP LP
Beneficial Owner (10% or more) | Option Exercise
16-Apr-08 | 4,814,725
16-Apr-08 | NGUYEN TRAN
Officer | Ownership Statement
2-Mar-09 | 0
2-Mar-09 | ORONSKY ARNOLD L
Director | Option Exercise
16-Apr-08 | 3,717,282
16-Apr-08 | STONER ELIZABETH
Director | Ownership Statement
23-Apr-08 | 0
23-Apr-08 |
|
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