| Individual/Entity | Most Recent Trans. | Shares Owned as of Trans. Date | BARCLAYS PLC Beneficial Owner (10% or more) | Ownership Statement 22-Sep-08 | 5,657,407
22-Sep-08 | DAVIS A BRIAN Officer | Disposition (Non Open Market) 30-Jul-07 | 28,955 30-Jul-07 | DEFREES SHAWN A Officer | Ownership Statement 4-Feb-08 | 18,328 4-Feb-08 | DOVEY BRIAN H Director | Option Exercise 27-Jan-09 | 3,348,842 27-Jan-09 | GAGE L PATRICK Director | Option Exercise 27-Jan-09 | 75,397 27-Jan-09 | HAMILTON WILLIAM F PHD Director | Option Exercise 27-Jan-09 | 70,821 27-Jan-09 | MACMASTER JR DOUGLAS J Director | Option Exercise 27-Jan-09 | 58,047 27-Jan-09 | PARKER H STEWART Director | Option Exercise 27-Jan-09 | 2,869 27-Jan-09 | POUL DEBRA J Officer | Disposition (Non Open Market) 30-Jul-07 | 37,997 30-Jul-07 | RACHESKY MARK H MD Director | Disposition (Non Open Market) 30-Mar-07 | 0
30-Mar-07 | TANG KEVIN C Beneficial Owner (10% or more) | Purchase 30-Sep-08 | 10,412,306
30-Sep-08 | VERGIS GEORGE J Officer | Disposition (Non Open Market) 30-Jul-07 | 29,235 30-Jul-07 | ZOPF DAVID A MD Officer | Disposition (Non Open Market) 30-Jul-07 | 32,445 30-Jul-07 |
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